
New therapy target for malignant melanomas in dogs
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Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.
In a study conducted at the University of Helsinki, researchers found a cause for severe epilepsy resulting in death in Parson Russell Terrier puppies at a few months of age. A change in the PITRM1 gene can lead to a dysfunction of mitochondria, the cellular energy pumps. Concurrently, amyloid-β accumulation and widespread neurodegeneration associated with Alzheimer's disease were identified in the puppies' brains. Changes to the PITRM1 gene in humans also cause a severe but slowly progressing brain disease.

Language is one of the most remarkable abilities humans have. It allows us to express complex meanings and transmit knowledge from generation to generation. An important question in human biology is how this ability evolved, and researchers from the universities of Barcelona, Cologne and Tokyo have tackled this issue in a recent article, published in the journal Trends in Cognitive Sciences.

In a proof-of-concept study led by the School of Veterinary Medicine, dogs identified positive samples with 96% accuracy.
An outbreak of vomiting among dogs has been traced back to a type of animal coronavirus by researchers. Vets across the country began reporting cases of acute onset prolific vomiting in 2019/20.

Between 2018 and 2020, 1,4 million EU citizens signed the petition 'End the Cage Age', with the aim of ending cage housing for farm animals in Europe. In response to this citizens initiative, the European Parliament requested a study by Utrecht University researchers on the possibilities to end cage housing. On 13 April, the scientists will present their report 'End the Cage Age - Looking for Alternatives' to the European Parliament.

New study reveals: fireflies produce strong ultrasonic sounds that might deter bats, potentially serving as a kind of 'musical armor' against these predators.

Six genetic variants add up to determine the risk of several blood cancers in pre-disposed dog breeds, according to a study by Benoît Hédan at the University of Rennes and colleagues, publishing April 8th in the open-access journal PLOS Genetics. The results confirm a known tumour-suppressor gene as a risk factor for histiocytic sarcoma -- a rare and aggressive blood cancer that affects both dogs and humans -- as well as identifying four new genetic loci associated with the disease.

Rabbits and other hopping animals require a functional RORB gene to move around by jumping, according to a new study by Miguel Carneiro of the Universidade do Porto and Leif Andersson of Uppsala University published March 25th in PLOS Genetics.

The more colorful a food, the more nutritious it probably is. For example, purple corn contains compounds associated with a reduced risk of developing diabetes and heart disease. The cobs contain the same compounds but are typically thrown out. Now, researchers report a step-wise biorefinery approach in ACS Sustainable Chemistry & Engineering that uses the whole cob, producing a dye and a possible nutraceutical with the pigments, and an animal litter with the left-overs.