Cancer cells use an ancient mechanism of self-nonself discrimination to remain hidden from the immune system. A nanoscale molecular machine, akin to an arm that flexes and extends, allows cancer cell to fend off immune. defenders. The stiff-arm is delivered by components of the complement system. It prevents the initiation of immune responses, without which the current generations of immunotherapeutics, like checkpoint inhibitors, are not effective. The hypotheses presented in the paper are pre-clinical.
Cost information, when paired with information about clinical treatment options, greatly enhances the value of shared decision making, reported a FAIR Health brief released today. This was among the lessons learned from a FAIR Health initiative presenting patient decision aids for shared decision making in palliative care scenarios, as described in the brief Cost Information Enhances Shared Decision Making: Lessons from FAIR Health's Shared Decision-Making Initiative.
By fostering visitors' individual feelings of ownership of a public resource, visitors will feel more responsible for it, take better care of it, and donate more time and money for its benefit.
The impact of the coronavirus pandemic has created concerns amongst the scientific research community that funding to their area will be impacted in the long term, a global survey shows. Half (47%) of those surveyed believe less funding will be available in their area in the future because of COVID-19.
A group of doctors is calling on the government to divert the hundreds of millions of pounds being spent on the failing centralised privatised COVID-19 national test and trace service into local primary care, local NHS labs and local public health services.
A world-first double-blind clinical trial, will investigate if a powerful drug used to treat nausea in chemotherapy patients, could alleviate hallucinations in people with Parkinson's.
A new study suggests that the status of award nominees combined with the level of social connection that they have with members of a judging panel can work both ways towards determining how successful they are -- depending on whether or not they are judged publicly or privately.
With more than $1.5 million in funding from the National Cancer Institute, MUSC Hollings Cancer Center researchers discovered a new biomarker, plasmacytoid dendritic cells expressing the ICOS ligand, whose activity can be blocked by the dual-acting drug candidate ALPN-101 to prevent graft-versus-host disease following hematopoietic stem cell transplantation.
Appeals seeking donations to help fight hunger during the COVID-19 pandemic were more successful when the typeface in which the appeal was written mirrored the tone of the donation request, a new study has found.
Researchers at Center for BrainHealth® collaborated with scientists at the University of North Carolina at Chapel Hill to examine whether the SMART program affects people's abilities to make informed decisions about their medical treatment options. Patients with rheumatoid arthritis are often reluctant to take antirheumatic drugs because of perceptions about the drugs' risks and benefits. The findings point to an approach that helps these patients, and other people, make more informed decisions about their health.