Traumatic brain injuries, whether suffered from a blow on the football field or the battle field, can be devastating, leading to disability and shortened lives. However, little is known about how different levels of injury and time affect the brain, hindering efforts to develop effective treatments. Scientists now report results from rodent studies in ACS' Journal of Proteome Research showing that signaling molecules are likely involved in mild cases, also known as concussions.
Women have many options for oral contraceptives that are safe, effective and reversible, but despite decades of research, men have none. Now, scientists report a rat study in ACS' Journal of Medicinal Chemistry that shows they finally have a good lead for a male birth control pill. It's based on ouabain, a plant extract that African warriors and hunters traditionally used as a heart-stopping poison on their arrows.
A recent paper published in the journal Molecular Psychiatry explores how a protein named CK2 could play a key role in the formulation of new antidepressants that work more efficiently and faster for more people.
Between sights, sounds, smells and other senses, the brain is flooded with stimuli on a moment-to-moment basis. How can it sort through the flood of information to decide what is important and what can be relegated to the background? Though popularly known as the 'love hormone,' a team of Harvard researchers found evidence that oxytocin actually plays a crucial role in helping the brain process a wide array of social signals.
A group of scientists from the Siberian Federal University (SFU, Krasnoyarsk, Russia) and the Nikolaev Institute of Inorganic Chemistry (NIIC, Novosibirsk, Russia) combined the useful properties of metal phthalocyanines and palladium membranes in order to create active layers in hydrogen detectors. This operation significantly increases the sensitivity of the sensors. The study is reported in the journals Dyes and Pigments and International Journal of Hydrogen Energy.
Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) in Japan have demonstrated that that moss can be a green alternative for decontaminating polluted water and soil. Published in PLOS ONE, the study shows that in particular, the moss Funaria hygrometrica tolerates and absorbs an impressive amount of lead (Pb) from water.
Scientists have unveiled incredible images of how the DNA code is read and interpreted -- revealing new detail about one of the fundamental processes of life.
A new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5'-Nucleotidase, a promising target for developing anti-cancer drugs.
For anyone who has accidentally injured themselves, Dr. Zachary Campbell not only sympathizes, he's developing new ways to blunt pain. Campbell, who researches pain on the molecular level at the University of Texas at Dallas, recently published a study in the journal Nature Communications that describes a new method of reducing pain-associated behaviors with RNA-based medicine, creating a new class of decoy molecules that prevent the onset of pain.
Cleveland Clinic researchers have confirmed for the first time a mechanistic link between the gene HSD17B4 and deadly, treatment-resistant prostate cancer. The research, led by Nima Sharifi, M.D., Cleveland Clinic Lerner Research Institute, Department of Cancer Biology, shows that men who lack a certain subtype of the gene may be more susceptible to aggressive prostate cancer that does not respond to treatment.