Mount Sinai researchers find this network central to Alzheimer's disease susceptibility.
Just as people endlessly calculate how to upsize or downsize, bacteria continually adjust their volume (their stuff) to fit inside their membrane (their space). But what limits their expansion? The answer will suprise you.
Engineers at Washington University in St. Louis and Princeton University developed a new way to dive into the cell's tiniest and most important components. What they found inside membraneless organelles surprised them, and could lead to better understanding of fatal diseases including cancer, Huntington's and ALS.
Researchers from Kumamoto University in Japan have found that the compound folic acid-conjugated methyl-BETA-cyclodextrin (FA-M-BETA-CyD) has significant antitumor effects on folate receptor-ALPHA-expressing (FR-ALPHA (+)) cancer cells. The compound significantly reduced ATP production while simultaneously increased the production of reactive oxygen species. Side effects in animal models were minimal but further testing is still required to determine its safety.
An international research team has found a way to improve the anti-cancer effect of a new medicine class called 'Smac mimetics.'
Your cancer has metastasized. No one wants to ever hear that. Now researchers have developed a method to thwart cell migration and thus halt metastasis in vitro. In past tests in vivo, the treatment has wiped out tumors with no observable signs of toxicity or recurrence.
Tetanus toxin is the neurotoxin that causes lockjaw. Many are vaccinated, but tetanus still kills tens of thousands of people per year worldwide. Researchers from the Department of Biochemistry and Biophysics, led by Dr. Pål Stenmark, have now uncovered the poison's structure. For the first time, the way the poison is constructed has been revealed.
Most organisms share the biosynthetic pathways for making crucial nutrients because it is is dangerous to tinker with them. But now a collaborative team of scientists has caught plants in the process of altering where and how cells make an essential amino acid.
A technique for inserting a gene into specific cell types in the adult brain can be used to alter the function of brain circuits and change behaviors in an animal model. The method will allow scientists to better understand what roles certain cell types play in the brain's complex circuitry. Researchers hope the approach might someday lead to developing treatments for conditions like epilepsy that might be curable by activating a small group of cells.
Researchers at The University of Texas at Dallas are getting more out of the sweat they've put into their work on a wearable diagnostic tool that measures three diabetes-related compounds in microscopic amounts of perspiration. In a study published recently in Nature Scientific Reports, the team describes their wearable diagnostic biosensor that can detect three interconnected compounds - cortisol, glucose and interleukin-6 - in perspired sweat for up to a week without loss of signal integrity.