Tel Aviv University reseachers have found that fat cells play a key role in the dangerous transformation of melanoma.
University of Guelph researchers have uncovered how the cannabis plant creates pain-relieving molecules that are 30 times more powerful at reducing inflammation than Aspirin. The discovery unlocks the potential to create a naturally derived pain treatment.
All life is cellular, but the origins of cellularity remain unknown. Scientists at the Earth-Life Science Institute have discovered that simple organic compounds like glycolic and lactic acid polymerize and self-assemble into cell-sized droplets when dried and rewetted, as might have happened along primitive beaches and drying puddles. These cell-like compartments can trap and concentrate biomolecules, and can merge and separate, forming versatile and heterogeneous cell-like containers possibly critical for the origin of life.
The August edition of SLAS Technology features the cover article, 'Technologies for the Directed Evolution of Cell Therapies,' a review featured in the journal's March 2019 edition. The research, led by Dino Di Carlo, Ph.D., (University of California Los Angeles) highlights how the next generation of therapies are moving beyond the use of small molecules and proteins to using whole cells.
In new research published in Proceedings of the National Academy of Sciences, Hollis Cline, Ph.D., and her colleagues at Scripps Research shed new light on the role that exosomes play in brain development. They show that exosomes are not only integral to the development of neurons and neural circuits, but they can restore health to brain cells affected by developmental disease.
Virginia Tech researcher Clément Vinauger has discovered new neurobiology associated with mosquito vision and sense of smell that explains how Aedes aegypti mosquitoes track their victims.
The enzyme ribonucleotide reductase is a bottleneck for cancer cell growth. Scientists at Winship Cancer Institute of Emory University have identified a way of targeting ribonucleotide reductase that may avoid the toxicity of previous approaches, informing focused drug discovery efforts.
Researchers isolated a molecule that may be under-produced in the guts of patients.
Programmable structural dynamics successful for first time in self-organizing fiber structures.
Almost all living organisms have gate-like protein complexes in their cell membranes that get rid of unwanted or life-threatening molecules. These ABC transporters are also responsible for resistance to antibiotics or chemotherapy. Researchers at Goethe University Frankfurt, together with the Max Planck Institute of Biophysics, which is also located in Frankfurt, have now succeeded in decrypting all the stages of the transport mechanism.