A study shows that the expression of PI3Kγ protein increases during infection by T. cruzi, an essential response in avoiding excessive inflammation and controlling parasitemia. Heart tissue analyses involving human patients who developed cardiopathy in the disease's chronic stage also provided results. The next challenge is to devise treatment for Chagas using molecules capable of modulating the cellular signaling pathway mediated by PI3Kγ.
Arranging into well-organized fibrillar aggregate, commonly known as amyloid fibril is an inherent property of any polypeptide chain. Amyloid fibrils are associated with a number of severe human pathologies like the Alzheimer's disease, Parkinson's disease, type 2 diabetes and many more. This review article includes the recent studies of identification and characterization of possible conformations of proteins which can act as aggregation precursor state (APS).
The genome of the algae species Chara braunii has been decoded. It already contains the first genetic characteristics that enabled the water plants' evolutionary transition to land.
Researchers at York University's Faculty of Health have found that patients who have metabolic healthy obesity, but no other metabolic risk factors, do not have an increased rate of mortality. The results of this study could impact how we think about obesity and health.
When a cell divides, its constituents are usually evenly distributed among the daughter cells. UZH researchers have now identified an enzyme that guarantees that cell constituents that are concentrated in organelles without a membrane are properly distributed. Their discovery opens up new opportunities for the treatment of cancer, neurodegenerative diseases, aging processes and viral infections.
Kyoto University researchers have developed a new approach to control the fabrication of soft, porous materials, overcoming a primary challenge in materials science.
When applied to cells, pulsed electric fields increase membrane permeability. Researchers have used this effect to force the diffusion of extracellular calcium into cells. Cell death occurs more easily in cancer cells since they are particularly sensitive to high amounts of calcium. Researchers from Kumamoto University in Japan have optimized pulsed electric field settings in an effort to attack cancer but leave healthy cells intact.
A new and promising class of chemical compounds has major potential for treating Zika virus and respiratory syncytial virus, or RSV, according to a new study by University of Alberta scientists. The next step is to develop a drug.
A new study sheds light on the mystery of how evolution tweaks the brain to shape behavior. It started with a close look at two Drosophila species and their mating maneuvers.
The compound urea is currently the most popular nitrogen soil fertilizer. It's a way to get plants the nitrogen they need to grow. There's just one problem with urease: it works too well! New research suggests farmers may have a choice in how they slow the release of nitrogen, depending on their soil's acidity.