Cardiac fibrosis involves an increase of connective tissue in the cardiac muscle, causing a loss of function. Researchers at the Technical University of Munich (TUM) have now discovered that fibrosis occurs less frequently when microRNA 29 (miR-29) is suppressed in cardiac muscle cells. Older studies had suggested that it was in fact low levels of miR-29 that caused fibrosis. The new insights point to potential new approaches for developing drugs against fibrotic diseases.
A surprising discovery shows that a widely used and 20-year-old medicine used to treat multiple sclerosis can also beat a type of multi-resistant bacteria for which there are currently only a few effective drugs. The result may be of significance for the treatment of patients and in the battle against resistant bacteria.
Scientists at Université de Montreal's Department of Biochemistry and Molecular Medicine design better molecules that make it harder for plasmids to move between bacteria.
Researchers have identified biomarkers that can help with development of better treatments for schizophrenia.
Biliary atresia is the most common cause of liver transplants for children in the United States. Researchers report in Science Translational Medicine finding a strong biomarker candidate that could be used for earlier diagnosis and lifesaving treatments that could avoid more invasive procedures like liver transplant. A research team led by Cincinnati Children's Hospital Medical Center identified molecular markers of the disease in blood samples that accurately diagnosed the condition with greater than 90 percent sensitivity.
In a new research article published in the Journal of the American Geriatrics Society, scientists were able to conclude that developing dementia or Alzheimer's disease (the most common form of dementia) did not appear to be linked to taking proton pump inhibitors (PPIs).
Columbia University biologists have revealed a mechanism by which bacterial cells in crowded, oxygen-deprived environments access oxygen for energy production, ensuring survival of the cell. The finding could explain how some bacteria, such as Pseudomonas aeruginosa (P. aeruginosa), are able to thrive in oxygen-poor environments like biofilms and resist antibiotics. P. aeruginosa biofilm infections are a leading cause of death for people suffering from cystic fibrosis, a genetic condition that affects the lungs and the digestive system.
Human genome editing, 3-D-printed replacement organs and artificial photosynthesis - the field of bioengineering offers great promise for tackling the major challenges that face our society. But as a new article out today highlights, these developments provide both opportunities and risks in the short and long term.
New treatments for dry eye disease that deliver lipids to the ocular surface are designed to more closely mimic the important tear film lipid layer at the air-water interface in the eye.
A cheap and widely used drug, used to treat conditions such as heartburn, gastritis and ulcers, could work against the bacteria that cause tuberculosis (TB), according to new research published in PLOS Medicine, from UCL and the London School of Hygiene & Tropical Medicine.