A Colorado State University laboratory is putting chemistry to work on a simple, inexpensive way to identify falsified or substandard antibiotics, offering a practical solution to a very real problem. The researchers have created a paper-based test that can quickly determine whether an antibiotic sample is appropriate strength, or diluted with filler substances like baking soda. Similar to the mechanism of a home pregnancy test, a strip of paper turns a distinctive color if a falsified antibiotic is present.
Studying the effects of contraceptive medications on feral cat populations is difficult, but relying on standard laboratory settings is unrealistic. That's why a group of University of Illinois researchers created a unique study environment designed to bridge the gap between the lab and the real world. In short, it's a cat wonderland in which resident cats help to advance science.
Scientists at the MDI Biological Laboratory and the University of Maine have discovered that genetic material in the cell that was previously thought to be 'junk' because of its apparent lack of function likely plays a part in regulating genetic circuits responsible for regeneration in highly regenerative animals. The discovery could one day lead to the development of drugs to trigger the dormant pathways for regeneration in humans.
TPU researchers develop completely new catalytic methods for synthesizing oxo-derivatives of betulin, which is an organic substance contained in the birch bark. In the age of green chemistry the cosmetic and food industries, especially the pharmaceutical industry are interested in the environment-friendly synthesis of these derivatives which function, for example, as building materials for many medicines.
Researchers from MIT and the University of Naples Federico II found that fragments of the protein pepsinogen, an enzyme used to digest food in the stomach, can kill bacteria such as Salmonella and E. coli. Such peptides could potentially be developed as new antibiotics.
A drug policy researcher is proposing a suite of changes to overhaul the Multi-Criteria Drug Harm Scale, which informs drug policies across Europe. The changes focus on addressing use and abuse separately, collecting input from a broader range of stakeholders, and targeting substance-specific experts for drug review panels.
For the first time, scientists have figured out why drugs that aim to treat Parkinson's disease, migraines, pituitary tumors, and obesity activate the serotonin receptor 5-HT2B to cause life-threatening heart problems. Published in Nature Structure & Molecular Biology, this research provides drug developers with much needed insights into serotonin receptors -- insights that should help scientists create safer more effective drugs, not just for the aforementioned conditions, but also depression, anxiety, and schizophrenia.
A new scale for tumour DNA mutations which will simplify and standardise choices for targeted cancer treatment has been agreed by leading cancer specialists in Europe and North America. The scale, called ESCAT (ESMO Scale for Clinical Actionability of molecular Targets), is published this week in the Annals of Oncology. It aims to optimise patient care by making it easier to identify patients with cancer who are likely to respond to precision medicines, and help make treatment more cost effective.
By turning off an important step of cellular recycling, metastatic cancer cells become unable to survive the stresses of traveling through the body.
About 50,000 people in the US are diagnosed annually with head, neck, nasal and oral cancers. Most are treated with radiation, and of those, 70-80 percent develop a painful and debilitating side effect called severe oral mucositis. Researchers will present their results on a new drug that could potentially prevent the condition today at the 256th National Meeting & Exposition of the American Chemical Society.