Respiratory disease patients with arthritis could struggle to manage their conditions because their inhalers are too fiddly for them to use, University of Bath research has found.
Cetuximab (CET) is a monoclonal antibody that inhibits epidermal growth factor receptor (EGFR) used for immunotherapy of different types of cancer. This study describes the development and full validation of a new enzyme-linked immunosorbent assay (ELISA) with high sensitivity and selectivity for bioanalysis of CET.
55 patients representing 17 cancer types tested positive for TRK fusion and were treated with larotrectinib. Overall response rate was 75 percent.
Carbon monoxide can improve the effectiveness of antibiotics, making bacteria more sensitive to antibiotic medication, according to a study led by Georgia State University.
Two novel ocular hypotensive agents that have just been approved for use in humans -- netarsudil and latanoprostene bunod (LBN) -- greatly reduce intraocular pressure, with lasting results in various animal models of glaucoma and in humans.
Study by Brazilian researchers shows infection by Zika caused death of cells from glioblastoma, the most common and aggressive kind of malignant brain tumor in adults. Scientists foresee the use of genetic engineering to neutralize Zika virus' infectious whilst preserving the viral particles which induce the death of tumoral cells.
Peptides, short amino acid chains that control many functions in the human body, represent a billion-dollar market, also in the pharmaceutical industry. But, normally these medications must be injected. A research team led by the Technical University of Munich (TUM) has now determined how peptides can be designed so that they can be easily administered as a liquid or tablet.
The bacterium Streptomyces chartreusis is an antibiotic-producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. Many of the substances are likely released to mediate interactions with its environment. They might also include molecules that are of interest as potential pharmaceutical agents. A research team analysed a broad spectrum of the bacterium's metabolic products under various culture conditions.
The project may pave the way for the development of more effective painkillers for the treatment of this debilitating chronic condition, which afflicts approximately 500 million people throughout the world.
Prophylactic use of the drug haloperidol does not help to prevent delirium in intensive care patients or improve their chances of survival. Therefore, there is no reason anymore to administer the drug as a preventive measure to reduce the burden of delirium. This was revealed following a three-year, large-scale study among 1,800 patients in 20 Dutch ICUs, headed by Radboud university medical center.