FAU's Harbor Branch houses more than 1,000 strains of actinobacteria, one of the most prolific microbial groups for the production of natural products. Derived from sea sponges and other macro-organisms, several strains were identified for their potent antifungal activity, for anti-MRSA activity, and for both antifungal and antibacterial activities. A key finding was the identification of a strain that produced metabolites that are more potent than the bacterial antibiotic, vancomycin, against C. difficile.
This approach is being assessed by Public Health England for its potential to routinely test all meningococcal disease cases.
'This new method should allow us to explore a large 'chemical space' that had been essentially off-limits.'
Scientists take on a major bottleneck in drug development.
EPFL and US scientists have developed a computational method that can design synthetic cell receptors that can be used to isolate how drugs work in a cell, minimize or even altogether prevent side effects and redirect their action.
Research published in JAMA Internal Medicine found that tamsulosin does not significantly effect patient-reported passage or capture of kidney stones.
Scientists report finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma. Publishing online June 18 in Nature Cell Biology, the study also reports the current lack of a drug that hits the molecular target keeps it from being advanced for testing as a therapeutic strategy for patients with few treatment options. The researchers point to a protein that helps regulate cell metabolism called AMPK (AMP-activated protein kinase).
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis.
New preclinical research shows a gene already linked to a subset of people with autism spectrum disorder is critical to healthy neuronal connections in the developing brain, and its loss can harm those connections to help fuel the complex developmental condition. Scientists report in Developmental Cell their data clarify the biological role of the gene CHD8 and its protein CHD8 in developing oligodendrocytes, cells that form a protective insulation around nerves.
The PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity, while PIM-1 and PIM-3 are positive regulators, report Medical University of South Carolina investigators in The Journal of Clinical Investigation. Blocking PIM-2 in allogeneic bone marrow transplant dramatically accelerated graft-versus-host disease. In adoptive immunotherapy with autologous T cells, silencing PIM-2 on T cells produced robust tumor immunity, highlighting the importance of PIM-specific inhibition.