University of New Mexico researchers identify three existing drugs with the potential to clear SARS-CoV-2 infections.
Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS' Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR.
Instability of small interfering RNA (siRNA) is one of the obstacles in the development of siRNA-based drugs. Researchers at Tokyo Metropolitan Institute of Medical Science and Tokyo University of Science have developed a new strategy for improvement of siRNA stability by using an artificial cationic oligosaccharide combined with phosphorothioate linkages.
Secreted protein Reelin is famous for its role in the migration and morphogenesis of neurons. Here we show that it also regulates the proliferation and radial distribution of oligodendrocyte progenitor cells (OPCs). Because abnormalities in OPC development or function are involved in the pathogenesis of many neurological diseases, our findings may be relevant in understanding and therapeutic development of those disorders.
Reelin exhibits a context-dependent function during brain development; however, its underlying mechanism is not well understood. Here, we found that neuropilin-1 specifically binds to the C-terminal region of Reelin and acts as a co-receptor for canonical Reelin-receptor. The Reelin-Nrp1 interaction is essential for proper dendritic development in superficial-layer neurons. This study provides evidence of the context-specific function of Reelin regulated by the C-terminal residues.
More than 20 million people in the U.S. suffer neuropathic pain. At least 25% of those cases are classified as unexplained and considered cryptogenic sensory polyneuropathy (CSPN). There is no information to guide a physician's drug choices to treat CSPN, but a researcher from the University of Missouri School of Medicine and MU Health Care led a first-of-its-kind prospective comparative effectiveness study.
A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU), has discovered a novel antiviral strategy for treatment of COVID-19.
Aetion co-authored a study published today in Science, which examined lethal coronaviruses SARS-CoV-2, SARS-CoV-1, and MERS-CoV to identify molecular characteristics of potential treatments. The study, which was led by the Quantitative Biosciences Institute at UCSF and involved nearly 200 researchers from leading institutions, applied a novel approach to evaluate molecular hypotheses by analyzing real-world data from COVID-19 patients.
There are common vulnerabilities among three lethal coronaviruses, SARS-CoV-2, SARS-CoV-1 and MERS-CoV, such as frequently hijacked cellular pathways, that could lead to promising targets for broad coronavirus inhibition, according to a study by an international research team that includes scientists from the Institute for Biomedical Sciences at Georgia State University.
A new study published in JAMA Network Open finds that as many as 90 percent of CBD users think it's real medicine, taking CBD to treat nearly all medical conditions, including substance use withdrawal, atrial fibrillation, and erectile dysfunction, to name a few.