Outer membrane vesicles, biological nanoparticles shed during normal growth by bacteria, have seen significant recent advances in engineering and are thus finding new utility as therapeutic and drug delivery agents. One specific research focus explored recently in the literature is the use of bacterial vesicles as adjuvants in vaccine formulations.
Scientists at Tokyo Institute of Technology (Tokyo Tech), Nagasaki University have identified four potential protein inhibitors and unlocked drug discovery strategies for the treatment of Chagas disease by using advanced three-dimensional computer simulation by supercomputer TSUBAME in combination with in vitro experiments and X-ray crystallography. Through this "smart drug discovery" in which IT drug discovery and biochemical experiments cooperate, they identified hit compounds for target protein with a hit rate of 20 times or more than conventional High Throughput Screening (HTS) methods.
Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries, significantly reducing the expense and time needed to develop therapeutics from an underexplored collection of molecules.
New research by a team of health experts at the University of Nottingham has found evidence that being in a positive mood on the day of your flu jab can increase its protective effect.
A phase 3 study of children ages 6-12 years with attention deficit/hyperactivity disorder (ADHD) has shown that a delayed-release, long-acting formulation of the stimulant methylphenidate, when taken in the evening, led to significant improvement in ADHD symptoms and functional impairment first thing the next morning, compared to a placebo.
A new technique that targets drugs to specific cells could lead to improved therapies for diseases caused by an overactive immune response. The research from the University of Edinburgh could help people affected by conditions such as arthritis and inflammatory bowel diseases, where the body's own immune system mistakenly attacks healthy tissues.
Left- and right-handed versions of molecules can be hard to tell apart but can have devastatingly different effects. The Dionne lab is developing an optical filter to sort these molecules, which could lead to purer and safer drugs and agrichemicals.
A new study involving patients with stage IV cancer finds that treatment with radiation therapy and immunotherapy can halt the growth of tumors by stimulating the body's immune system to attack the cancer.
Efforts to remove barriers to accessing emergency contraception (EC) scored victories in 2013, when the US Food and Drug Administration removed age restrictions on over-the-counter sales of the levonogestrel drug Plan B.
For years, medical investigators have tried and failed to develop vaccines for a type of staph bacteria associated with the deadly superbug MRSA. But a new study by Cedars-Sinai investigators shows how staph cells evade the body's immune system, offering a clearer picture of how a successful vaccine would work.