Louis Populin and collaborators at the University of Wisconsin-Madison collaborators published a study this week in the Journal of Neuroscience describing increased connections between key parts of the brains of monkeys who have taken methylphenidate (Ritalin).
The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized and characterized using advanced spectroscopic techniques such as NMR, HR-MS and IR.
An international team has developed a novel pharmaceutical formulation to administer triclabendazole -- an anti-parasitic drug used to treat a type of flatworm infection -- in billions of tiny capsules.
An increasing number of scientists are including female animals in their experimental designs and analyses for preclinical studies, as required by the National Institutes of Health (NIH) in January 2016, reports a new study. But NIH reviewers are not necessarily considering that inclusion when they score an application for funding, which was a goal of the requirement.
Like people in a large company, proteins in cells constantly interact with each other to perform various jobs. To develop new disease therapies, researchers are trying to control these interactions with small-molecule drugs that cause specific proteins to associate more or less with their 'coworkers.' Now, researchers reporting in ACS' journal Analytical Chemistry have developed a method to visualize whether drugs are regulating protein-protein interactions inside cells.
It costs the global economy an estimated US $2 trillion annually and has been dubbed a modern day health epidemic, but new research from the University of South Australia has unearthed a possible cure for obesity -- and it is as plain as dirt!
Researchers at Kanazawa University report in The Journal of Organic Chemistry that carboxylic acids, functional groups contained in biomolecules, drugs, and materials can be readily modified by light-induced organic reactions using an aminocyclopropenone. This discovery opens up new pathways for carboxylic acid modification with potential applications including determination of drug target proteins, elucidation of protein function, and synthesis of functionalized polymer materials.
New research by the University of Calgary's Dr. Abhay Lodha, MD, shows early caffeine treatment of premature babies born less than 29 weeks' gestation has no long-term negative effects on brain development.
Portland State University researchers have made a significant breakthrough by developing the 3D structure of proteins from inside the eye lens that control how cells communicate with each other, which could open the door to treating diseases such as cataracts, stroke and cancer
Dangerous antibiotic-resistant bacteria could soon be targeted with a drug initially developed to treat Alzheimer's disease. University of Queensland-led research investigated the antibacterial properties of metal transport drug, PBT2.