Scientists at Scripps Research have successfully tested a potential new smoking-cessation treatment in rodents.
The current study demonstrates a deleterious effect of midazolam administration prior to myocardial ischemia and reveals reduced circadian protein Period 2 (PER2) levels as the underlying mechanism. These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancer nobiletin as preventative therapy for myocardial injury in the perioperative setting where midazolam pretreatment occurs frequently.
Biochemists, microbiologists, drug discovery experts and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice. Instead of killing causative bacteria with antibiotics, researchers treated infected mice with molecules that block toxin formation in bacteria. Every treated mouse survived. The breakthrough study, published in Scientific Reports, suggests infections in humans might be cured the same way.
Osaka University researchers have devised a simple method to measure the amount of cancer medication nivolumab that is bound to immune T-cells. The method requires just a drop of blood and can also measure the level of proliferation of those T-cells. The researchers show that these tests provide much more useful information for making treatment decisions than blood levels of the medication alone. Using these methods should also help reduce adverse reactions to therapy.
Misuse of prescription opioids or benzodiazepines (such as Xanax) was associated with suicidal ideation in a study of US older adults.
In a study of 15 patients affected by major depressive disorder and complaining of insomnia, initiating treatment with vortioxetine for their depressive symptoms led to significant improvements in subjective sleep quality and daytime sleepiness.
Data on the molecular makeup and drug sensitivity of hundreds of patient samples could accelerate progress against the aggressive blood cancer acute myeloid leukemia.
Treatment quickly reduced the animals' motivation to take nicotine, reversed their signs of nicotine dependence, and kept them from relapsing when they were given access to nicotine again.
By studying a chemical produced predominately in the liver, hypertension researchers at The University of Toledo have found a novel approach to lower blood pressure, even without reducing sodium intake or increasing exercise.
New findings presented today by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients -- those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy. Once validated, the findings could point the way to improved strategies for the staging and ordering of key immunotherapies in refractory melanoma.