The Lung Cancer Mutation Consortium at the University of Colorado Cancer Center reports this week in the journal Cancer that 24 of 920 patients (3 percent) with advanced-stage lung cancer had mutations in the gene HER2.
The European Food Safety Authority, the European Medicines Agency and the European Centre for Disease Prevention and Control are concerned about the impact of use of antibiotics on the increase in antibiotic-resistant bacteria. The report presents new data on antibiotic consumption and antibiotic resistance and reflects improved surveillance across Europe.
Researchers have found a surprisingly versatile workaround to create chemical compounds that could prove useful for medical imaging and drug development.
The size of protein-based drug molecules prevents their absorption into the body when taken orally making injection (intramuscularly, subcutaneously, intravenously, etc.) the only effective delivery method. Research into transdermal drug delivery systems to make taking these drugs easier and cheaper has lead Japanese researchers to develop a new transdermal thermal abrasion system. It uses near-infrared light to irradiate gold nanorods in a gel skin patch to increase skin permeability for improved drug delivery.
A new study led by researchers at University Hospitals Coventry and Warwickshire NHS Trust and the University of Warwick has recommended an alternative method of pain relief for patients undergoing knee replacement surgery.
While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells.
"We know that inflammatory diseases occur much more frequently in women than in men," says Prof. Oliver Werz of the Friedrich Schiller University Jena. The german pharmacist and his team, together with colleagues from Italy, Denmark and Sweden, have uncovered a significant cause for these sex differences at the molecular level. In two high-profile publications they show how the male sex hormone testosterone interferes with the biosynthesis of inflammatory substances, and additionally reduces the effectiveness of anti-inflammatory drugs.
Two rare diseases caused by a malfunctioning gene that triggers seizures or involuntary movements in children as early as a few days old have left scientists searching for answers and better treatment options. Michigan State University researchers are closer to understanding the source, a gene known as GNAO1 and the transformations it can take on, and potentially stopping its devastating effects by uncovering key differences in the way it functions.
'What has been missing in clinical trials may just be the timing of the treatments,' says first author Lynsey Fettig.
An overwhelming majority of Americans (86%) agree that health care professionals should discuss clinical trials with patients diagnosed with a disease as part of their standard of care, according to a new national public opinion survey commissioned by Research!America. And three-quarters of respondents (75%) agree that taking part in clinical trials is as valuable to our health care system as giving blood.