A University of California, Riverside, research team has come up with a new approach to targeting cancer cells that circumvents a challenge faced by currently available cancer drugs.
Metals such as zinc, copper and chromium bind to and influence a peptide involved in insulin production, according to new work from chemists at UC Davis. The research is part of a new field of 'metalloendocrinology' that takes a detailed look at the role of metals in biological processes in the body.
Pain medication addiction is a major problem in the United States. UVA's Ken Hsu is seeking ways to treat pain and control inflammation without dangerous side effects.
Synthetic proteins have now been created that can move in response to their environment in predictable and tunable ways. These proteins can use their movement to disrupt lipid membranes in cells. They show promise as tools for drug delivery, and might eventually rival the efficiency of virus vehicles, but without some of their drawbacks.
A new drug that inhibits neonatal seizures in rodent models could open up new avenues for the treatment of epilepsy in human newborns.
Study describes a way to reduce the duration of tuberculosis treatment by using an approach called 'artificial intelligence-parabolic response surface' that allows researchers to quickly identify three or four drug combinations among billions of possible combinations to treat TB up to five times faster than current therapies.
GPs must be better-equipped to support patients to manage the psychological challenge of reducing their opioid use -- according to new research from the University of East Anglia. The recommendation is part of a toolkit being launched today to help GPs reduce the amount of opioids they prescribe. The toolkit outlines seven areas of best practice to tackle chronic opioid use -- based on international research evidence, the experiences of health organisations and individual practitioners.
A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology.
Scientists from the University of Groningen, the University of Amsterdam, the University of Twente (all in the Netherlands) and the European Laboratory for Non-Linear Spectroscopy in Italy, have been able to follow the entire sequence of structural transformations in a new class of molecular switches for the first time. By identifying 'control knobs' to direct their operation, better control of their performance is now possible.
A team of scientists led by Prof. R. Sowdhamini at the National Centre for Biological Sciences (NCBS), Bengaluru, has recently deciphered the transcriptome by purifying and sequencing RNA from five different tissues (root, stem, flower, seed and leaf) of the Moringa tree.