New oral anticoagulants (NOACs) represent direct-acting drugs functioning selectively for one specific clotting factor. Their clinical indications are the prophylaxis and treatment of deep venous thrombosis and pulmonary embolism, the prevention of atherothrombotic episodes of individuals with acute coronary syndromes and atrial fibrillation
Oregon shore crabs exhibit risky behavior when they're exposed to the antidepressant Prozac, making it easier for predators to catch them, according to a new study from Portland State University (PSU).
Following a successful clinical trial involving Dana-Farber Cancer Institute and Brigham and Women's Hospital, the first chimeric antigen receptor (CAR) T-cell therapy for adult cancers was approved by the Food and Drug Administration (FDA) today. Dana-Farber/Brigham and Women's Cancer Center, the only facility in the northeast to be part of the clinical trial, is one of a few locations certified to offer this new therapy nationwide.
University of Pittsburgh scientists are unlocking the complexities of a recently discovered cell death process that plays a key role in health and disease, and new findings link their discovery to asthma, kidney injury and brain trauma. The results, reported today in the journal Cell, are the early steps toward drug development that could transform emergency and critical care treatment.
A University of Colorado Cancer Center study published today in the journal ACS Nano describes the use of cutting-edge microscopy technology to visualize how liposomes escape from blood vessels into surrounding cells in a living mouse, offering clues that may help researchers design better drug delivery systems.
Scientists at the Department of Energy's Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant tuberculosis, malaria and diabetes. Specifically, the team used neutron crystallography to study the location of hydrogen atoms in aspartate aminotransferase, or AAT, an enzyme vital to the metabolism of certain amino acids.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a molecular model that may provide a new framework for improving the design of osteoporosis treatments.
Scientists from RUDN University have synthesized a number of new cytotoxic substances - the ones that can damage cells. In the future the results of the study can be used in cancer therapy. The compounds were obtained by domino reaction, a successive formation of several new chemical bonds. The study was published in the Synthesis journal
Indoloquinoline alkaloids are of great importance due to their unique structure and various biological activities. Several methods have been developed to synthesize indoloquinolines and among those, one-pot methods are of particular importance due to its simplified reaction procedure.
Portuguese researchers successfully used a pioneer method to chemically modify a protein's components with potential medical applications and an impact in the fight against tuberculosis.