The final research results for a new treatment for protection against accidental exposure to peanut was presented today at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting and published in the New England Journal of Medicine.
Scientists from the University of Sheffield have discovered a new inhibitor which decreases lung inflammation and could hold the key to treating Acute Respiratory Distress Syndrome -- a life-threatening disease which affects thousands of people in the UK.
Using a highly-detailed musculoskeletal model of an echidna forelimb, Harvard scientists are not only shedding new light on how the little-studied echidna's forelimb works, but are also opening a window into understanding how extinct mammals might have used their forelimbs.
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure.
A surprising discovery about a failed pain drug -- and specifically, the pathway it targets, BH4 -- could have implications for autoimmunity and cancer. Neuroscientists at Boston Children's Hospital and immunologists from IMBA in Vienna report that BH4 also functions as a kind of immunological thermostat, raising and lowering the activity levels of T cells. Inhibiting BH4 could relieve atopic dermatitis, psoriasis, lupus, polyarthritis and inflammatory bowel disease; boosting it could help the immune system attack cancers.
Lowering mutation rates in harmful bacteria might be an as yet untried way to hinder the emergence of antimicrobial pathogens. One target for drug development might be a protein factor, DNA translocase Mfd, that enables bacteria to evolve rapidly by promoting mutations in many different bacterial species. This action speeds antibiotic resistance, including multi-drug resistance. Working on drugs to block Mfd and similar factors could be a revolutionary strategy to address the worldwide crisis of treatment-resistant infectious diseases.
Color can impact the taste of food, and our experiences and expectations can affect how we taste food, according to Penn State researchers, who suggest this may have implications for how food and beverage industries should market their products.
UCLA biologists reveal the hidden molecular basis of brain disorders and provide the first cell atlas of the hippocampus -- the part of the brain that helps regulate learning and memory -- as it is affected by traumatic brain injury. The researchers propose gene candidates for treating brain diseases associated with traumatic brain injury such as Alzheimer's disease and post-traumatic stress disorder.
In one of the largest studies to measure the burden of antibiotic resistance in a low- or middle-income country, researchers at the Center for Disease Dynamics, Economics & Policy report that in-hospital mortality is significantly higher among patients infected with multi-drug resistant (MDR) or extensively drug resistant (XDR) pathogens including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii.
Facioscapulohumeral muscular dystrophy (FSHD) is the most prevalent dominantly inherited muscular dystrophy in the world. To date, there are no pharmacologic treatments available for the more than 850,000 people affected worldwide. Developing models to use for testing potential therapeutics has been a challenge for the research community.