IMAGE: Lung squamous cell carcinoma

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Shorter Versions of p53 Promote, Rather Than Halt Cancer

Shorter Versions of p53 Promote, Rather Than Halt Cancer
Full-length p53 -- the tumor suppressor we depend upon -- consists of 11 exons, or protein-coding segments (top). Alternative splicing and gene mutation can give rise to truncated p53 proteins that ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Cells Pushed Toward Metastasis

Cells Pushed Toward Metastasis
Cells that express exon 6-truncated p53 protein exhibit structural features that reflect their reprogramming away from stability and toward proliferation and metastasis. This was apparent when ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Cervical Cancer Cells

Cervical Cancer Cells
Cervical cancer cells show green fluorescence from enzyme-activated compound.

Contact: Thomas Deane
deaneth@tcd.ie
353-189-64685
Trinity College Dublin

Drug Penetrates the Brain to Thwart Lung Tumor Spread

Drug Penetrates the Brain to Thwart Lung Tumor Spread
Brain magnetic resonance imaging (MRI) scan of a patient with multiple brain metastases (BM). This patient had two measurable BM lesions (white nodules) in the occipital and parietal lobes before ...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Handel, CCR2 and inhibitors, Skaggs School of Pharmacy and Pharmaceutical Sciences UC San Diego

Handel, CCR2 and inhibitors, Skaggs School of Pharmacy and Pharmaceutical Sciences UC San Diego
Right: Structure of CC chemokine receptor 2 (CCR2) bound to two inhibitors (pink and yellow). Left: Normally, chemokines outside the cell bind CCR2 and the receptor transmits that signal inside the ...

Contact: Heather Buschman
hbuschman@ucsd.edu
858-249-0456
University of California - San Diego

Melanin Migration (2 of 2)

Melanin Migration (2 of 2)
Melanin is being transported from melanocytes, where it is synthesized, to keratinocytes in the epidermis, which it protects.

Contact: David Kornhauser
comms@mail2.adm.kyoto-u.ac.jp
81-757-535-727
Kyoto University

Melanin Migration (1 of 2)

Melanin Migration (1 of 2)
Melanin is being transported from melanocytes, where it is synthesized, to keratinocytes in the epidermis, which it protects.

Contact: David Kornhauser
comms@mail2.adm.kyoto-u.ac.jp
81-757-535-727
Kyoto University

Figure A: microRNAs

Figure A: microRNAs

microRNAs (miRNA) are recently discovered, short segments of RNA, which play vital roles in health and disease. microRNA over- or under-abundance can switch critical disease genes on or off, ...

Contact: Richard Harth
RICHARD.HARTH@ASU.EDU
504-427-2666
Arizona State University

Cancer Causer

Cancer Causer
The human papillomavirus causes not only cervical cancer but also cancers of the head and neck.

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Critical Genes Unravelled to Understand Human Diseases and Support Drug Discovery

Critical Genes Unravelled to Understand Human Diseases and Support Drug Discovery
Critical paralogs (CP) can conduct the same incoming signal to different cellular responses like cell-death, differentiation, or cell proliferation through cross-talks between signalling pathways. ...

Contact: Hayley London
hayley.london@earlham.ac.uk
07-760-438-218
Earlham Institute

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