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Public Release: 27-Oct-2016
Promising blood test fails to yield clues about strategies for bladder cancer treatment
A blood test that has shown promise in predicting how cancer will progress and what treatments will be most effective for a given patient may not be reliable for either, according to a new Penn Medicine study published this week in Cancer, a peer-reviewed journal of the American Cancer Society.

Contact: John Infanti
University of Pennsylvania School of Medicine

Public Release: 27-Oct-2016
Cell Reports
Promise of better targeted treatments now possible in children's brain cancer
More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer. Writing this week in the journal Cell Reports, researchers at Huntsman Cancer Institute (HCI) at the University of Utah report they have identified an existing group of drugs that appear to reduce or eliminate a certain subgroup of childhood brain cancers while sparing normal brain tissue.
National Institutes of Health, Canadian Institute of Health Research, American Cancer Society, Huntsman Cancer Foundation

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 26-Oct-2016
Mutations in bone cells can drive leukemia in neighboring stem cells
DNA mutations in bone cells that support blood development can drive leukemia formation in nearby blood stem cells. This neighbor cell effect was observed in a mouse model of Noonan syndrome. In mice, drugs can stop the effect and potentially could combat leukemia progression/recurrence.
NIH/National Heart Lung and Blood Institute, NIH/National Institute for Diabetes and Digestive and Kidney Diseases

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 26-Oct-2016
Self-renewable cancer killer cells could be key to making immunotherapy work
A small molecule that can turn short-lived 'killer T-cells' into long-lived, renewable cells that can last in the body for a longer period of time, activating when necessary to destroy tumor cells, could help make cell-based immunotherapy a realistic prospect to treat cancer.
Wellcome Trust

Contact: Craig Brierley
University of Cambridge

Public Release: 26-Oct-2016
ACS Nano
Imaging where cancer drugs go in the body could improve treatment
Nanomedicine has the potential to help personalize cancer treatments and reduce side effects of therapeutic drugs. While some progress has been made toward the latter goal, customized treatments are still hard to come by. Now scientists report in the journal ACS Nano a new step toward seeing where certain cancer drugs accumulate in the body in order to better treat patients. They tested their drug-carrying, lipid-based nanoparticles in animals.

Contact: Michael Bernstein
American Chemical Society

Public Release: 26-Oct-2016
Journal of the American College of Surgeons
Older and younger women benefit equally from breast reconstruction after mastectomy
The most comprehensive study of its kind to date found that older women enjoy the same benefits from breast reconstruction following mastectomy for breast cancer as younger women without a significant increase in the risk for complications.
NIH/National Cancer Institute

Contact: Devin Rose
American College of Surgeons

Public Release: 26-Oct-2016
Telerehabilitation through Internet ameliorate the life of women suffering breast cancer
Researchers from the University of Granada (UGR) and from hospitals Virgen de las Nieves and San Cecilio (Granada) have proved that telerehabilitation (rehabilitation with the help of the Internet, using the application Skype as a control platform) may help to alleviate the side effects associated with breast cancer and its treatment, like pain, fatigue, strength loss, deterioration of the quality of life, etc.

Contact: Noelia Galiano Castillo
University of Granada

Public Release: 26-Oct-2016
Current Biology
Scripps Florida team illuminates molecular player in morphine addiction and rare disease
In a remarkable 'two for one' discovery, scientists from the Florida campus of The Scripps Research Institute (TSRI) have illuminated a key molecular player in the addictive effects of morphine in animal models.
National Institutes of Health, US Department of Defense

Contact: Eric Sauter
Scripps Research Institute

Public Release: 26-Oct-2016
American Society of Hematology
Clinical Oncology
Mayo Clinic study shows that choice of medical center impacts life expectancy of multiple myeloma patients
People diagnosed with multiple myeloma are more likely to live longer if they are treated at a medical center that sees many patients with this blood cancer. Mayo Clinic researchers published these findings today in the Journal of Clinical Oncology.
Mayo Clinic, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery

Contact: Elizabeth Zimmermann Young
Mayo Clinic

Public Release: 26-Oct-2016
ACS Nano
How nanoscience will improve our health and lives in the coming years
Nanoscience research involves molecules 100 times smaller than cancer cells with the potential to profoundly improve the quality of our health and our lives. Now nine prominent nanoscientists look ahead to what we can expect in the coming decade, and conclude that nanoscience is poised to make important contributions in many areas, including health care, electronics, energy, food and water.

Contact: Stuart Wolpert
University of California - Los Angeles

Public Release: 26-Oct-2016
American Journal of Preventive Medicine
Georgia State finds perception of e-cigarette harm growing among US adults
The proportion of American adults who perceive e-cigarettes to be equally or more harmful than traditional cigarettes has tripled over the last few years, highlighting the need for more accurate public health messaging, according to a study led by tobacco researchers in the School of Public Health at Georgia State University.
NIH/National Institute of Drug Abuse, FDA Center for Tobacco Products

Contact: Anna Varela
Georgia State University

Public Release: 25-Oct-2016
Cell Reports
IU research finds link between molecular mechanisms in prostate cancer and Ewing's sarcoma
Medical researchers at Indiana University have found evidence for a link between prostate cancer, which affects millions of men age 50 and older, and Ewing's sarcoma, a rare form of cancer that affects children and young adults. The results appear in the journal Cell Reports.
American Cancer Society

Contact: Kevin D. Fryling
Indiana University

Public Release: 25-Oct-2016
Cell Reports
A new look at vitamin D challenges the current view of its benefits
It's widely accepted that vitamin D is good for bones. But what if it plays a much larger role in health than is currently accepted? Recent research at the Buck Institute points in that direction -- at least in the nematode worm. The study shows vitamin D works through longevity genes and impacts processes associated with many human age-related diseases. The research is prompting some clinicians to call for universal vitamin D supplementation.
Larry L. Hillblom Foundation, Glenn Foundation for Medical Research, National Institutes of Health

Contact: Kris Rebillot
Buck Institute for Research on Aging

Public Release: 25-Oct-2016
Science Advances
Structure of key DNA replication protein solved
Mount Sinai researchers say the protein structure can be used to improve effectiveness of chemotherapy.
NIH/National Institute of General Medical Sciences, National Institutes of Health, NIH/Office of Research Infrastructure Programs High-End Instrumentation

Contact: Lucia Lee
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 25-Oct-2016
Terminally ill cancer patients fare poorly after surgery
Patients with disseminated advanced cancer who undergo surgery are far more likely to endure long hospital stays and readmissions, referrals to extended care facilities and death, UC Davis researchers have found.

Contact: Dorsey Griffith
University of California - Davis Health System

Public Release: 25-Oct-2016
Nature Biotechnology
Quantum leap in the reliability of mass spectrometry-based proteomics
Modern mass spectrometry systems enable scientists to routinely determine the quantitative composition of cells or tissue samples. However, different analysis software packages often produce different results from the same raw data. An international team of researchers led by Professor Stefan Tenzer from the Mainz University Medical Center has now addressed this problem by comparing and modifying various analysis software packages to ensure that the different software solutions produce consistent results.

Contact: Dr. Stefan Tenzer
Johannes Gutenberg Universitaet Mainz

Public Release: 25-Oct-2016
High levels of estrogen in lung tissue related to lung cancer in postmenopausal women
Researchers from Kumamoto University, Japan have found that postmenopausal women with multicentric adenocarcinoma of the lung have a higher concentration of estrogen in non-cancerous areas of the peripheral lung than similar women diagnosed with single tumor lung cancer. The research is an extension of their previous investigation into a gene mutation found to be related to an increased risk of multicentric lung cancer.
Japanese Grant-in-Aid for Scientific Research from MEXT, Smoking Research Foundation

Contact: J. Sanderson, N. Fukuda
Kumamoto University

Public Release: 25-Oct-2016
Journal of Proteome Research
Fat in feces points to early presence of colorectal cancer
Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer.

Contact: Herbert Hill, WSU Department of Chemistry
Washington State University

Public Release: 24-Oct-2016
Scientific Reports
A key to unlocking the mystery of triple negative breast cancer
The study suggests screening breast cancer patients for the prolactin receptor could improve the prognosis for patient and may help them avoid unnecessary and invasive treatments. The researchers found that prolactin hormone was able to reduce the aggressive behavior of cancerous cells. It does so by decreasing their ability to divide and form new tumors.

Contact: Valerie Harvey
514-934-1934 x71381
McGill University Health Centre

Public Release: 24-Oct-2016
Journal of Clinical Investigation
Study suggests that autophagy inhibitors could improve efficacy of chemotherapies
This week in the JCI, research led by Jayanta Debnath at UCSF has shown that inhibiting autophagy does not impair the immune response to tumors during chemotherapy, providing support for the idea that combining autophagy inhibitors with certain chemotherapies may aid cancer treatment.
NIH/National Cancer Institute, DOD/Breast Cancer Research Program

Contact: Elyse Dankoski
JCI Journals

Public Release: 24-Oct-2016
Study determines efficacy of 2 drugs to treat a form of leukemia
Researchers have determined that two Phase 1 drugs (CX-4945 and JQ1) can work together to efficiently kill T-cell acute lymphoblastic leukemia cells while having minimal impact on normal blood cells.
Boston University, National Institutes of Health, Leukemia Research Foundation, St. Baldrick Foundation, Rally Foundation, Alex's Lemonade Stand Foundation

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 24-Oct-2016
New subtypes of lung cancer can lead to personalized therapies with better outcome
Analysis of vast amounts of molecular data from a set of more than 1,000 non-small cell lung cancers identifies distinct subtypes, each with its own molecular profile and potentially different response to therapy.

Contact: Allison Huseman
Baylor College of Medicine

Public Release: 24-Oct-2016
Redox Biology
Boosting levels of known antioxidant may help resist age-related decline
Researchers have found that a specific detoxification compound, glutathione, helps resist the toxic stresses of everyday life -- but its levels decline with age and this sets the stage for a wide range of health problems. It may be possible to restore glutathione levels and help prevent some of the metabolic declines associated with aging.
National Institutes of Health

Contact: Tory Hagen
Oregon State University

Public Release: 24-Oct-2016
Nature Medicine
Fighting cancer with the power of immunity
Researchers at MIT's Koch Institute for Integrative Cancer Research have developed a new strategy for using immunotherapy to treat cancer. The researchers used a combination of four different therapies to activate both branches of the immune system, producing a coordinated attack that led to the disappearance of large, aggressive tumors in mice.
Koch Institute, NIH/National Cancer Institute, National Institutes of Health, Dana-Farber/Harvard Cancer Center, The V Foundation, and The Ragon Institute

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 24-Oct-2016
Scientific Reports
Tumor markers can reveal lethality of bladder cancers, guide treatment
Tumor cells collected during the removal of a cancerous bladder and transplanted into mice with weakened immune systems could help physicians rapidly identify high-risk cancers, determine prognosis and refine the use of biomarkers to personalize care for patients with this common cancer.
Ludwig Cancer Research, Rosalind and Burton Spellman Family Cancer Fund, Foglia Foundation and Mr. and Ms. Vincent Foglia

Contact: John Easton
University of Chicago Medical Center

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