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Public Release: 8-Dec-2016
San Antonio Breast Cancer Symposium
Radiation therapy may increase complications in breast cancer patients receiving implants
Radiotherapy increased complications and impaired patient-reported satisfaction with reconstructed breasts in breast cancer patients who received implant reconstruction but not in those who received autologous reconstruction, according to data from a large, prospective, multicenter cohort study presented at the 2016 San Antonio Breast Cancer Symposium, held Dec. 6-10.
NIH/National Cancer Institute

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research

Public Release: 8-Dec-2016
Journal of Molecular Diagnostics
DNA methylation biomarker for prostate cancer shows promise for accurately determining patient risk
Report in The Journal of Molecular Diagnostics describes a biomarker, PITX2 DNA methylation, which is capable of distinguishing cancerous tissue from non-cancerous tissue and predicting the risk of cancer recurrence using only small amounts of tissue obtained from core needle biopsies.
University Hospital Bonn

Contact: Eileen Leahy
jmdmedia@elsevier.com
732-238-3628
Elsevier Health Sciences

Public Release: 8-Dec-2016
JAMA Oncology
Blood-borne HPV antibodies indicate head, neck cancer prognosis
A new study in JAMA Oncology finds that the presence of particular antibodies of human papillomavirus in blood serum are reliable indicators of five-year head and neck cancer survival.
NIH/National Cancer Institute, NIH/National Institutes of Environmental Health Sciences, Minnesota Masonic Charities

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 8-Dec-2016
San Antonio Breast Cancer Symposium
More complications, less satisfaction in breast cancer patients who get radiation, implants
A new study finds that breast cancer patients who have implant reconstruction following radiation therapy had more complications from the surgery and were less satisfied with the result than women who had implants but no radiation.
NIH/National Cancer Institute

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 8-Dec-2016
JAMA Oncology
Tumor found in a 255-million-year-old mammalian ancestor
A tumor in a 255-million-year-old mammalian ancestor called a gorgonopsian is detailed in a new research letter published online by JAMA Oncology.

Contact: James Urton
jurton@uw.edu
206-543-2580
The JAMA Network Journals

Public Release: 8-Dec-2016
JAMA Oncology
Study shows new treatment strategy in head & neck cancer not better than current standard
Results of the largest Canadian clinical trial to date comparing standard treatment for locally advanced squamous cell head and neck cancer with an experimental treatment did not show the new treatment is superior.
Amgen Inc., Canadian Cancer Society Research Institute, The Princess Margaret Cancer Foundation

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 7-Dec-2016
San Antonio Breast Cancer Symposium
JAMA Oncology
New study shows targeted therapy needed for breast cancer with brain metastases
Researchers at the University of Pittsburgh Cancer Institute and Magee-Womens Research Institute have discovered molecular changes in the primary tumor of breast cancer patients who developed brain metastases. The finding is expected to lead to improved diagnosis and targeted therapies.
Breast Cancer Research Foundation, NIH/National Cancer Institute, Fashion Footwear Association of New York, Shear Family Foundation, Magee-Womens Research Institute and Foundation, Susan G. Komen for the Cure, National Institute of General Medical Science

Contact: Cyndy Patton
PattonC4@upmc.edu
412-586-9773
University of Pittsburgh Schools of the Health Sciences

Public Release: 7-Dec-2016
San Antonio Breast Cancer Symposium
Genetic alterations more common in tumors of older patients with metastatic breast cancer
In a preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers report that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on genetic sequencing results.

Contact: Laura Oleniacz
laura_oleniacz@med.unc.edu
919-445-4219
UNC Lineberger Comprehensive Cancer Center

Public Release: 7-Dec-2016
Cancer
Novel test enables earlier detection of Merkel cell carcinoma, Fred Hutch scientists say
New research findings show how immune system marker can supplement and often outperform imaging studies for recurrence of Merkel cell carcinoma
National Institutes of Health, National Center for Advancing Translational Sciences, Merkel Cell Carcinoma Patient Gift Fund at the University of Washington

Contact: Jonathan Rabinovitz
jrabinov@fredhutch.org
206-667-6906
Fred Hutchinson Cancer Research Center

Public Release: 7-Dec-2016
San Antonio Breast Cancer Symposium
Scientists developing model to predict if chemotherapy will work for breast cancer
In a study presented at the 2016 San Antonio Breast Cancer Symposium, researchers report that they developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy.

Contact: Laura Oleniacz
laura_oleniacz@med.unc.edu
919-445-4219
UNC Lineberger Comprehensive Cancer Center

Public Release: 7-Dec-2016
Nucleic Acids Research
One specific gene explains many diseases
Genetic differences in the FADS1 gene determine the risk for many different diseases. The ability to produce polyunsaturated fats like omega-3 and omega-6 differs between individuals and this affects the risk for disturbed metabolism, inflammatory diseases and several types of cancer. Scientists at Uppsala University/SciLifeLab in Sweden have clarified this in detail and the work is published in the journal Nucleic Acids Research.

Contact: Claes Wadelius
claes.wadelius@igp.uu.se
46-070-425-058
Uppsala University

Public Release: 7-Dec-2016
New England Journal of Medicine
Cellular immunotherapy targets a common human cancer mutation
n a study of an immune therapy for colorectal cancer that involved a single patient, a team of researchers at the National Cancer Institute identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene. This targeted immunotherapy led to cancer regression in the patient in the study.

Contact: NCI Press Office
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute

Public Release: 7-Dec-2016
2016 San Antonio Breast Cancer Symposium
Brain metastasis persists despite improved targeted treatment for HER2 breast cancer
While new targeted treatments developed across the past two decades have led to dramatic survival improvements for women with HER2-positive metastatic breast cancer, University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators report that rates of breast cancer brain metastasis for women with this disease have not substantially declined.

Contact: Laura Oleniacz
laura_oleniacz@med.unc.edu
919-445-4219
UNC Lineberger Comprehensive Cancer Center

Public Release: 7-Dec-2016
ESMO Asia 2016 Congress
Patients wait 4 months before seeking cancer diagnosis
Patients wait an average of four months before seeking a cancer diagnosis, researchers report at the ESMO ASIA 2016 Congress in Singapore. Some patients waited less than a week before seeing a doctor while others waited three years.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 7-Dec-2016
Nature
Stem cell-based test predicts leukemia patients' response to therapy to tailor treatment
Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.
Ontario Institute for Cancer Research, Cancer Stem Cell Consortium, Canadian Institutes of Health Research, Canadian Cancer Society, Terry Fox Foundation, Canada Research Chair in Stem Cell

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 7-Dec-2016
Chemical Communications
Scientists develop exciting new option for targeted cancer therapy
Scientists at Trinity College Dublin have identified a new option for more targeted cancer therapy. Their method should allow greater doses of cancer drugs to be administered with fewer side-effects, because the drugs are inactive in the body until being sparked into life when coming into contact with cancer cells.
Science Foundation Ireland

Contact: Thomas Deane
deaneth@tcd.ie
353-189-64685
Trinity College Dublin

Public Release: 7-Dec-2016
American Journal of Physiology
Enzyme that digests vitamin A also may regulate testosterone levels
Bco1, an enzyme that metabolizes beta carotene, may play a vital role in testosterone metabolism as well, according to a new study led by researchers at the University of Illinois.
National Institutes of Health

Contact: Sharita Forrest
slforres@illinois.edu
217-244-1072
University of Illinois at Urbana-Champaign

Public Release: 7-Dec-2016
Leukemia
Two genetic mutations discovered in subset of acute myeloid leukemia
Two genetic mutations known to play a role in many solid cancers might also help explain why a subset of acute myeloid leukemia (AML) patients develop the disease.
NIH/National Cancer Institute, Leukemia Clinical Research Foundation, Warren D. Brown Foundation, Pelotonia Fellowship Program

Contact: Amanda Harper
amanda.harper2@osumc.edu
614-685-5420
Ohio State University Wexner Medical Center

Public Release: 7-Dec-2016
Nature
Researchers reveal 3-D structure of cell's inflammation sensor and its inhibitors
Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have now determined the 3-D structure of CCR2 simultaneously bound to two inhibitors. Understanding how these molecules fit together may better enable pharmaceutical companies to develop anti-inflammatory drugs that bind and inhibit CCR2 in a similar manner. The study is published Dec. 7 by Nature.
National Institutes of Health

Contact: Heather Buschman
hbuschman@ucsd.edu
858-249-0456
University of California - San Diego

Public Release: 7-Dec-2016
Nature
Tumor cells are dependent on fat to start metastasis
A study headed by Salvador Aznar Benitah, ICREA researcher at the Institute for Research in Biomedicine (IRB Barcelona), and published today in Nature identifies metastasis-initiating cells through a specific marker, namely the protein CD36. This protein, which is found in the membranes of tumor cells, is responsible for taking up fatty acids. CD36 activity and dependence on lipid (fat) metabolism distinguish metastasis-initiating cells from other tumor cells.
Fundació La Marató de TV3, World Wide Cancer Research of the UK, Fundación Botín and Banco Santander, European Research Council

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 7-Dec-2016
IASLC 2016 World Conference on Lung Cancer
Summary of research presented at the IASLC 17th World Conference on Lung Cancer
Today's press briefing at the IASLC 17th World Conference on Lung Cancer (WCLC) focused on clinical trials that advance the progress made in lung cancer treatment through immunotherapy and better diagnostics. Abstracts and full versions of news releases for each topic covered are available through links in this summary, or through IASLC media representative Chris Martin.

Contact: Chris Martin
cmartin331@comcast.net
630-670-2745
International Association for the Study of Lung Cancer

Public Release: 7-Dec-2016
Scientific Reports
Safety in darkness
With a little help from chickens and video cameras, scientists have captured live the moment when skin gets darker. In a study appearing in Scientific Reports, a Japanese team has filmed and demystified the process by which melanin -- molecules that give skin its color -- are carried to the epidermis.
AMED Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science

Contact: David Kornhauser
comms@mail2.adm.kyoto-u.ac.jp
81-757-535-727
Kyoto University

Public Release: 7-Dec-2016
BMC Public Health
Public urged to be more body vigilant in fight against cancer, new study finds
New research published in BMC Public Health has found that increased body vigilance may contribute to early cancer diagnosis. In the first study of its kind, researchers from the University of Surrey who received funding from Cancer Research UK, found that people who are more body vigilant were more likely to seek professional medical help.

Contact: Natasha Meredith
n.meredith@surrey.ac.uk
01-483-684-380
University of Surrey

Public Release: 7-Dec-2016
ESMO Asia 2016 Congress
Supportive care for cancer patients remains inadequate
Pain relief and other forms of supportive care for cancer patients are insufficient, researchers report at the ESMO ASIA 2016 Congress in Singapore. They also highlight that side-effects to chemotherapy must be treated efficiently and that doctors should ensure end-of-life treatment meets patients' expectations.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 7-Dec-2016
Genome Research
Atlas of the RNA universe takes shape
In the last few years, small snippets of RNA, which may have played a key role in the planet's earliest flickering of life, have been uncovered and examined in great detail. Their discovery, first in the tiny soil-dwelling nematode worm C. elegans and shortly thereafter, across the web of life, marks a revolution in biology, with broad implications in the fight against nearly every known disease.

Contact: Richard Harth
RICHARD.HARTH@ASU.EDU
504-427-2666
Arizona State University

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