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Public Release: 7-Dec-2016
Nature
Researchers reveal 3-D structure of cell's inflammation sensor and its inhibitors
Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have now determined the 3-D structure of CCR2 simultaneously bound to two inhibitors. Understanding how these molecules fit together may better enable pharmaceutical companies to develop anti-inflammatory drugs that bind and inhibit CCR2 in a similar manner. The study is published Dec. 7 by Nature.
National Institutes of Health

Contact: Heather Buschman
hbuschman@ucsd.edu
858-249-0456
University of California - San Diego

Public Release: 7-Dec-2016
Nature
Stem cell-based test predicts leukemia patients' response to therapy to tailor treatment
Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.
Ontario Institute for Cancer Research, Cancer Stem Cell Consortium, Canadian Institutes of Health Research, Canadian Cancer Society, Terry Fox Foundation, Canada Research Chair in Stem Cell

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 7-Dec-2016
Cancer
Novel test enables earlier detection of Merkel cell carcinoma, Fred Hutch scientists say
New research findings show how immune system marker can supplement and often outperform imaging studies for recurrence of Merkel cell carcinoma
National Institutes of Health, National Center for Advancing Translational Sciences, Merkel Cell Carcinoma Patient Gift Fund at the University of Washington

Contact: Jonathan Rabinovitz
jrabinov@fredhutch.org
206-667-6906
Fred Hutchinson Cancer Research Center

Public Release: 7-Dec-2016
New England Journal of Medicine
Cellular immunotherapy targets a common human cancer mutation
n a study of an immune therapy for colorectal cancer that involved a single patient, a team of researchers at the National Cancer Institute identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene. This targeted immunotherapy led to cancer regression in the patient in the study.

Contact: NCI Press Office
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute

Public Release: 7-Dec-2016
American Journal of Epidemiology
Optimism may reduce risk of dying prematurely among women
Having an optimistic outlook on life -- a general expectation that good things will happen -- may help people live longer, according to a new study from Harvard T.H. Chan School of Public Health. The study found that women who were optimistic had a significantly reduced risk of dying from several major causes of death -- including cancer, heart disease, stroke, respiratory disease, and infection -- over an eight-year period, compared with women who were less optimistic.
National Institutes of Health

Contact: Marge Dwyer
mhdwyer@hsph.harvard.edu
617-432-8416
Harvard T.H. Chan School of Public Health

Public Release: 7-Dec-2016
Environmental Science & Technology
Baby teethers soothe, but many contain low levels of BPA
Bisphenol-A (BPA), parabens and antimicrobials are widely used in personal care products and plastics. The US and other governments have banned or restricted some of these compounds' use in certain products for babies and kids. But the compounds' presence in and leaching from teethers hasn't been thoroughly investigated. Now a study in the ACS journal Environmental Science & Technology reports that all tested plastic teethers contained BPA and other endocrine-disruptors that leached at low levels.

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Public Release: 7-Dec-2016
Science Translational Medicine
Personalized cancer vaccine is associated with promising outcomes for patients with AML
A personalized vaccine created from AML patients' own immune cells and cancer cells linked to increased immune response against leukemia cells. Immunotherapy with the vaccine appears to prevent relapse with few side effects in a 17-patient trial.
NIH/National Cancer Institute, Leukemia and Lymphoma Society Translational Research Program

Contact: Teresa Herbert
therbert@bidmc.harvard.edu
617-667-7300
Beth Israel Deaconess Medical Center

Public Release: 7-Dec-2016
San Antonio Breast Cancer Symposium
Some breast cancer patients on neoadjuvant chemo may avoid axillary lymph node dissection
Axillary lymph node dissection could be avoided by certain early-stage breast cancer patients receiving neoadjuvant chemotherapy.
Institut National du Cancer

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research

Public Release: 7-Dec-2016
San Antonio Breast Cancer Symposium
JAMA Oncology
New study shows targeted therapy needed for breast cancer with brain metastases
Researchers at the University of Pittsburgh Cancer Institute and Magee-Womens Research Institute have discovered molecular changes in the primary tumor of breast cancer patients who developed brain metastases. The finding is expected to lead to improved diagnosis and targeted therapies.
Breast Cancer Research Foundation, NIH/National Cancer Institute, Fashion Footwear Association of New York, Shear Family Foundation, Magee-Womens Research Institute and Foundation, Susan G. Komen for the Cure, National Institute of General Medical Science

Contact: Cyndy Patton
PattonC4@upmc.edu
412-586-9773
University of Pittsburgh Schools of the Health Sciences

Public Release: 7-Dec-2016
ESMO Asia 2016 Congress
Patients wait 4 months before seeking cancer diagnosis
Patients wait an average of four months before seeking a cancer diagnosis, researchers report at the ESMO ASIA 2016 Congress in Singapore. Some patients waited less than a week before seeing a doctor while others waited three years.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 7-Dec-2016
Nature
Tumor cells are dependent on fat to start metastasis
A study headed by Salvador Aznar Benitah, ICREA researcher at the Institute for Research in Biomedicine (IRB Barcelona), and published today in Nature identifies metastasis-initiating cells through a specific marker, namely the protein CD36. This protein, which is found in the membranes of tumor cells, is responsible for taking up fatty acids. CD36 activity and dependence on lipid (fat) metabolism distinguish metastasis-initiating cells from other tumor cells.
Fundació La Marató de TV3, World Wide Cancer Research of the UK, Fundación Botín and Banco Santander, European Research Council

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 7-Dec-2016
American Journal of Physiology
Enzyme that digests vitamin A also may regulate testosterone levels
Bco1, an enzyme that metabolizes beta carotene, may play a vital role in testosterone metabolism as well, according to a new study led by researchers at the University of Illinois.
National Institutes of Health

Contact: Sharita Forrest
slforres@illinois.edu
217-244-1072
University of Illinois at Urbana-Champaign

Public Release: 7-Dec-2016
Genome Research
Atlas of the RNA universe takes shape
In the last few years, small snippets of RNA, which may have played a key role in the planet's earliest flickering of life, have been uncovered and examined in great detail. Their discovery, first in the tiny soil-dwelling nematode worm C. elegans and shortly thereafter, across the web of life, marks a revolution in biology, with broad implications in the fight against nearly every known disease.

Contact: Richard Harth
RICHARD.HARTH@ASU.EDU
504-427-2666
Arizona State University

Public Release: 7-Dec-2016
IASLC 2016 World Conference on Lung Cancer
Summary of research presented at the IASLC 17th World Conference on Lung Cancer
Today's press briefing at the IASLC 17th World Conference on Lung Cancer (WCLC) focused on clinical trials that advance the progress made in lung cancer treatment through immunotherapy and better diagnostics. Abstracts and full versions of news releases for each topic covered are available through links in this summary, or through IASLC media representative Chris Martin.

Contact: Chris Martin
cmartin331@comcast.net
630-670-2745
International Association for the Study of Lung Cancer

Public Release: 7-Dec-2016
Leukemia
Two genetic mutations discovered in subset of acute myeloid leukemia
Two genetic mutations known to play a role in many solid cancers might also help explain why a subset of acute myeloid leukemia (AML) patients develop the disease.
NIH/National Cancer Institute, Leukemia Clinical Research Foundation, Warren D. Brown Foundation, Pelotonia Fellowship Program

Contact: Amanda Harper
amanda.harper2@osumc.edu
614-685-5420
Ohio State University Wexner Medical Center

Public Release: 7-Dec-2016
ESMO Asia 2016 Congress
Supportive care for cancer patients remains inadequate
Pain relief and other forms of supportive care for cancer patients are insufficient, researchers report at the ESMO ASIA 2016 Congress in Singapore. They also highlight that side-effects to chemotherapy must be treated efficiently and that doctors should ensure end-of-life treatment meets patients' expectations.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 7-Dec-2016
Scientific Reports
Safety in darkness
With a little help from chickens and video cameras, scientists have captured live the moment when skin gets darker. In a study appearing in Scientific Reports, a Japanese team has filmed and demystified the process by which melanin -- molecules that give skin its color -- are carried to the epidermis.
AMED Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science

Contact: David Kornhauser
comms@mail2.adm.kyoto-u.ac.jp
81-757-535-727
Kyoto University

Public Release: 7-Dec-2016
BMC Public Health
Public urged to be more body vigilant in fight against cancer, new study finds
New research published in BMC Public Health has found that increased body vigilance may contribute to early cancer diagnosis. In the first study of its kind, researchers from the University of Surrey who received funding from Cancer Research UK, found that people who are more body vigilant were more likely to seek professional medical help.

Contact: Natasha Meredith
n.meredith@surrey.ac.uk
01-483-684-380
University of Surrey

Public Release: 6-Dec-2016
Scientific Reports
Critical genes unravelled to understand human diseases and support drug discovery
A network analysis of proteins that are most important in responding to environmental signals highlights potential targets for drugs and provides better information on the genetic basis of diseases.

Contact: Hayley London
hayley.london@earlham.ac.uk
07-760-438-218
Earlham Institute

Public Release: 6-Dec-2016
Melanoma Management
Research providing promising new treatments for melanoma
In a paper published online Nov. 30, 2016, in Melanoma Management, Adam Riker, M.D., Professor of Surgery and Chief of Surgical Oncology at LSU Health New Orleans School of Medicine, reviews approaches to manage melanoma, including one tested at LSU Health New Orleans that provoked a complete response in a patient with a long history of the disease.

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

Public Release: 6-Dec-2016
IASLC 2016 World Conference on Lung Cancer
Research presentations from the IASLC 17th World Conference on Lung Cancer Dec. 6
Today's press briefing at the IASLC 17th World Conference on Lung Cancer (WCLC) focused on active prevention, with researchers sharing results of clinical drug trials that have shown reduction in risk of disease progression among lung cancer patients. Abstracts and full versions of news releases for each topic covered are available, including the complete article on the AURA3 Trial that is published in today's New England Journal of Medicine.

Contact: Chris Martin
cmartin@davidjamesgroup.com
630-670-2745
International Association for the Study of Lung Cancer

Public Release: 6-Dec-2016
58th ASH Annual Meeting
Side effects of leukemia drug can be safely reduced by halving dose
Patients with a chronic type of leukemia could safely reduce the side effects of life-long treatment by cutting their dose in half, according to the results of a University of Liverpool led study presented at an international conference in America this week.

Contact: Nicola Frost
nicola.frost@liverpool.ac.uk
University of Liverpool

Public Release: 6-Dec-2016
EBioMedicine
Researchers find new biomarker for brain cancer prognosis
Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment.

Contact: Lori Sundeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 6-Dec-2016
Journal of Urology
How should patients be monitored for prostate cancer after a negative biopsy?
An expert panel of urologists and radiologists from the American Urological Association (AUA) and the Society of Abdominal Radiology (SAR) has published a set of consensus statements in The Journal of Urology® indicating that MRI (magnetic resonance imaging) targeted biopsy, when properly incorporated into clinical practice, can address such issues.

Contact: Eileen Leahy
jumedia@elsevier.com
732-238-3628
Elsevier Health Sciences

Public Release: 6-Dec-2016
IASLC 2016 World Conference on Lung Cancer
CTCA invited to international forum to present findings from multiple lung cancer studies
Lung cancer-based studies conducted at Cancer Treatment Centers of America® (CTCA) will be presented at the 17th International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer in Vienna, Austria, Dec. 4-7. These studies represent research conducted by members of the research team at Western Regional Medical Center led by Dr. Glen Weiss as they search for treatment options for varying types of lung cancer.

Contact: Nicole McTheny
Nicole.mctheny@ctca-hope.com
623-207-3983
Cancer Treatment Centers of America

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