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Public Release: 21-Oct-2016
Discovery of blood biomarkers for early pancreatic cancer detection
Pancreatic cancer is one of the most lethal forms of cancer. Early detection is essential to improve prognoses. Working toward that goal, a collaboration of researchers in Japan has discovered proteins in the blood which improve the detection of pancreatic cancer. When used in combination with conventional pancreatic cancer biomarkers, it enables the diagnosis of early stage pancreatic cancer, which was previously thought to be difficult.
Project for Development of Innovative Research on Cancer Therapeutics, Practical Research for Innovative Cancer Control, Project for Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Development

Contact: J. Sanderson, N. Fukuda
Kumamoto University

Public Release: 21-Oct-2016
Clinical Cancer Research
Presence of certain oral bacterium in esophageal cancer samples associated with shorter survival
Among Japanese patients with esophageal cancer, those whose cancer tested positive for DNA from the bacterium Fusobacterium nucleatum had shorter cancer-specific survival compared with those whose cancer had no DNA from the bacterium.
SGH Foundation

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 21-Oct-2016
Cancer Research
New oncogene linked to prostate cancer in African Americans may lead to better diagnostic tools
The new oncogene MNX1 is more active in African American than in European American prostate cancer.

Contact: Jeannette Jimenez
Baylor College of Medicine

Public Release: 21-Oct-2016
Microvascular Research
Danish researchers behind new cancer images
A Danish research team has developed a new method for studying how a tracer is distributed in a cancer tumor via its extensive vascular network. The method can be used for studying closely the effect of medical treatment using cancer inhibitors.

Contact: Jens Vinge Nygaard
Aarhus University

Public Release: 21-Oct-2016
Genes to Cells
Paving the road to drug discovery
When treated with an anti-cancer drug, ICRF-193, fission yeast produce an 'arched and snapped' phenotype that may be used to screen for other cancer drugs.

Contact: Kaoru Natori
Okinawa Institute of Science and Technology (OIST) Graduate University

Public Release: 21-Oct-2016
A new view of the immune system
Pathogen epitopes are fragments of bacterial or viral proteins. Nearly a third of all existing human epitopes consist of two different fragments. Known as 'spliced epitopes', these types of epitopes have long been regarded as rare. The fact that they are so highly prevalent might, among other things, explain why the immune system is so highly flexible. Results from this study have been published in the current issue of the journal Science.*

Contact: Dr. Michele Mishto
Charité - Universitätsmedizin Berlin

Public Release: 21-Oct-2016
Study links changes in collagen to worse pancreatic cancer prognosis
A study in the current journal Oncotarget provides the first evidence linking a disturbance of the most common protein in the body with a poor outcome in pancreatic cancer.

Contact: Kevin W. Eliceiri
University of Wisconsin-Madison

Public Release: 21-Oct-2016
Combating drug resistance in acute myeloid leukemia with a ceramide-based therapeutic
Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia. Targeting this pathway with a novel lipid-based therapeutic showed efficacy in a preclinical model of AML. These findings were reported in an article published in the Oct. 13, 2016 issue of Blood.
NIH/National Cancer Institute, NIH/National Institute of Dental and Craniofacial Research, James F. Bomar Myeloid Malignancy Research Fund held at the MUSC Hollings Cancer Center, Lipidomics Shared Resource

Contact: Heather Woolwine
Medical University of South Carolina

Public Release: 21-Oct-2016
Angewandte Chemie International Edition
Where does cisplatin bind?
Cisplatin is one of the most widely used agents in cancer chemotherapy. It cross-links DNA, which can kill cells. But which part of the genome is more affected, and which is less affected? A Chinese team have now set up a universal, genome-wide assay to detect the specific cisplatin action sites. In the journal Angewandte Chemie they report initial results, which support the notion that the mitochondrial genome is one of cisplatin's main targets.

Contact: Mario Mueller

Public Release: 20-Oct-2016
JAMA Oncology
More American men with early-stage prostate cancer could opt out of immediate treatment
A new report on Swedish men with non-aggressive prostate cancer suggests that a lot more American men could safely choose to monitor their disease instead of seeking immediate radiation treatment or surgery.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 20-Oct-2016
Nature Communications
Disturbance wanted
Some anticancer agents intend to disturb the function of the p97 protein complex, which is essential for survival of cancer cells. A team of researchers of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association has now found a way to break up the p97 complex into its subunits and published their results in Nature Communications.

Contact: Vera Glaßer
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Public Release: 20-Oct-2016
PLOS Computational Biology
Optimal treatment plan for chronic myeloid leukemia suggested by mathematical modeling
A new treatment plan that sequentially combines several drugs for chronic myeloid leukemia has the potential to reduce patients' chance of relapse and increase their life expectancy, according to a study published in PLOS Computational Biology.

Contact: Kevin Leder

Public Release: 20-Oct-2016
Cell Metabolism
Scientists reveal link between cell metabolism and the spread of cancer
A team led by Massimiliano Mazzone has demonstrated that the metabolism of macrophages, a particular type of white blood cell, can be attuned to prevent the spread of cancer. The key is in making these macrophages more prone to 'steal' sugar from the cells forming the tumor's blood vessels. As a result, these blood vessels will be structured more tightly, which can prevent cancer cells from spreading to other organs.

Contact: Sooike Stoops
VIB (the Flanders Institute for Biotechnology)

Public Release: 20-Oct-2016
American Society of Human Genetics 2016 Annual Meeting
Parents of children with cancer value sequencing results, even if non-actionable
Parents of children newly diagnosed with cancer value the results of whole exome sequencing for a variety of reasons beyond clinical actionability. Parents cited psychological benefits to receiving the information, such as explaining where the cancer had come from; as well as pragmatic benefits that helped them and their families plan for the future, such as knowledge that could help children make reproductive decisions of their own.

Contact: Nalini Padmanabhan
American Society of Human Genetics

Public Release: 20-Oct-2016
Withholding amino acid depletes blood stem cells, Stanford researchers say
A new study shows that a diet deficient in valine effectively depleted the blood stem cells in mice and made it possible to perform a blood stem cell transplantation on them.

Contact: Christopher Vaughan
Stanford University Medical Center

Public Release: 20-Oct-2016
Novel mechanisms of action discovered for skin cancer medication Imiquimod
Imiquimod is a medication successfully used in the treatment of skin diseases. In addition to its known mechanism of action, it also triggers other processes in the body. Scientists at the Technical University of Munich (TUM) have succeeded in explaining the molecular fundamentals of these additional effects. The results also shine a new light on other known molecular processes which could indicate an approach to the treatment of inflammatory illnesses.

Contact: Paul Hellmich
Technical University of Munich (TUM)

Public Release: 20-Oct-2016
Engineers, mathematicians and doctors unite to develop new breast cancer-detection option
A technique used to detect damage on structures under the sea was successfully repurposed to identify cancerous nuclei in breast cell images. Breast cancer is the most prevalent form of cancer for women worldwide, but current techniques for its automated detection are limited.
Science Foundation Ireland

Contact: Thomas Deane
Trinity College Dublin

Public Release: 20-Oct-2016
New compound shows promise in treating multiple human cancers
A new compound, discovered jointly by international pharmaceutical company Servier, headquartered in France, and Vernalis (R&D), a company based in the UK, has been shown by researchers at the Walter and Eliza Hall Institute and Servier to block a protein that is essential for the sustained growth of up to a quarter of all cancers.
Servier collaboration, National Health and Medical Research Council of Australia, Leukemia and Lymphoma Society, Cancer Council Victoria, Kay Kendall Leukemia Fund, Victorian Cancer Agency, Australian Cancer

Contact: Vanessa Solomon
Walter and Eliza Hall Institute

Public Release: 20-Oct-2016
Scientific Reports
A novel noninvasive imaging probe for fast and sensitive detection of cancer
The ultimate goal of cancer diagnostics is to develop sensitive imaging techniques for reliable detection of tumor malignancy in the body. Scientists at Tokyo Institute of Technology have come close to achieving this goal by developing an injectable imaging probe that can specifically detect solid tumors based on the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system.
Japan Society for the promotion of Science

Contact: Emiko Kawaguchi
Tokyo Institute of Technology

Public Release: 20-Oct-2016
Journal of Medicinal Chemistry
Scientists build a better cancer drug to pass through blood-brain barrier
In efforts to develop new treatments for brain cancer, scientists from Johns Hopkins Drug Discovery and the Kimmel Cancer Center's Bloomberg -- Kimmel Institute for Cancer Immunotherapy report they have altered the structure of an experimental drug that seems to enhance its ability to slip through the mostly impermeable blood-brain barrier.

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 20-Oct-2016
Science Translational Medicine
New research verifies TASINs as viable target for colon cancer therapies
A small molecule called TASIN-1 can selectively kill cells with a mutation that is considered to be a precursor to colon cancer, while sparing related normal cells, UT Southwestern Medical Center cancer biologists have demonstrated.
Cancer Prevention Research Institute of Texas, National Research Foundation of Korea, Institute for Innovations in Medicine, Harold C. Simmons Cancer Center, Disease Oriented Clinical Scholar Award, Damon Runyon Clinical Investigator Award, and others

Contact: Lori Sundeen Soderbergh
UT Southwestern Medical Center

Public Release: 19-Oct-2016
American College of Surgeons Clinical Congress 2016
One-third of breast cancer patients not getting appropriate breast imaging follow-up exam
An annual mammogram is recommended after treatment for breast cancer, but nearly one-third of women diagnosed with breast cancer aren't receiving this follow-up exam, according to new findings presented at the 2016 Annual Clinical Congress of the American College of Surgeons.
Patient-Centered Outcomes Research Institute, National Center for Advancing Translational Sciences, NIH/National Cancer Institute, Alliance for Clinical Trials in Oncology, American College of Surgeons Oncology Group, North Central Cancer Oncology Group

Contact: Devin Rose
American College of Surgeons

Public Release: 19-Oct-2016
Glycoconjugate Journal
Neu5Gc in red meat and organs may pose a significant health hazard
Neu5Gc, a non-human sialic acid sugar molecule common in red meat that increases the risk of tumor formation in humans, is also prevalent in pig organs, with concentrations increasing as the organs are cooked, a study by researchers from the UC Davis School of Medicine and Xiamen University School of Medicine has found.
Xiamen University School of Medicine, China

Contact: Carole Gan
University of California - Davis Health System

Public Release: 19-Oct-2016
Scientific Reports
Anti-cancer effects found in natural compound derived from onions
Research coming out of Kumamoto University, Japan has found that a natural compound isolated from onions has several anti-cancer properties. The compound prevented the proliferation of pro-tumor myeloid cells in both in vivo and in vitro experiments.
Japan Society for the Promotion of Science

Contact: J. Sanderson, N. Fukuda
Kumamoto University

Public Release: 19-Oct-2016
Integrative Biology
Study: Does a cancer cell's shape hint at its danger?
Paper published in the journal Integrative Biology shows that a cancer cell's shape may be combined with genomic data to offer a more precise prognosis and guide strategies for treating a patient's disease.

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

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