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Public Release: 26-Apr-2017
Study signals need to screen genes for stem cell transplants
New research shows that as stem cell lines grow in a lab dish, they often acquire mutations in the TP53 (p53) gene, an important tumor suppressor responsible for controlling cell growth. Findings suggest that genetic sequencing technologies should be used to screen for mutated cells in stem cell cultures, so that cultures with mutated cells can be excluded from experiments and therapies.
Harvard Stem Cell Institute, Stanley Center for Psychiatric Research, Rosetrees Trust and The Azrieli Foundation, Howard Hughes Medical Institute, Wellcome Trust, Medical Research Council, and others

Contact: David Cameron
Harvard University

Public Release: 26-Apr-2017
International Journal of Cancer
Italian-style coffee reduces the risk of prostate cancer
Add another typical component of the Italian way of life to the list of foods characterizing one of the most healthy populations in the world. This time it's coffee, prepared the Italian way. A research by the Department of Epidemiology and Prevention - I.R.C.C.S. Neuromed, Italy, in collaboration with the Italian National Institute of Health and the I.R.C.C.S. Istituto Dermopatico dell'Immacolata, shows that three or more cups a day can lower prostate cancer risk.

Contact: Americo Bonanni
Istituto Neurologico Mediterraneo Neuromed I.R.C.C.S.

Public Release: 26-Apr-2017
Tracking unstable chromosomes helps predict lung cancer's return
Scientists have found that unstable chromosomes within lung tumours increases the risk of cancer returning after surgery, and have used this new knowledge to detect relapse long before standard testing. These are the first findings from the Cancer Research UK-funded TRACERx lung cancer study, published today (Wednesday) in the New England Journal of Medicine and Nature.

Contact: Kathryn Ingham
Cancer Research UK

Public Release: 26-Apr-2017
Nature Communications
HIPPO's molecular balancing act helps nerves not short circuit
Scientists report Nature Communications it may be possible to therapeutically fine tune a constantly shifting balance of molecular signals to ensure the body's peripheral nerves are insulated and functioning normally. In a study published April 26, they suggest this may be a way to treat neuropathies or prevent the development of peripheral nerve sheath tumors. They discovered genetic dysfunction in the HIPPO-TAZ/YAP and Gαs-protein feedback circuit disrupts the balanced formation of the protective myelin sheath.

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 26-Apr-2017
Fighting cancer with immunotherapy: Signaling molecule causes regression of blood vessels
Immunotherapy with T-cells offers great hope to people suffering from cancer. Some initial successes have already been made in treating blood cancer, but treating solid tumors remains a major challenge. The signaling molecule interferon gamma, which is produced by T-cells, plays a key role in the therapy. It cuts off the blood supply to tumors, as a new study in the journal Nature reveals.

Contact: Vera Glaßer
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Public Release: 25-Apr-2017
Ancient stress response provides clues to cancer resistance
Cancer cells deploy an ancient mechanism used by single-celled organisms to elevate their mutation rate in response to stress. This discovery explains one of the best-known hallmarks of cancer -- its high mutation rate, which contributes to the rapid evolution of drug resistance.

Contact: Joseph Caspermeyer
Arizona State University

Public Release: 25-Apr-2017
American Journal of Obstetrics & Gynecology
Children conceived after fertility treatments are at increased risk for pediatric cancers
'The research concludes that the association between IVF and total pediatric neoplasms and malignancies is significant,' Prof. Sheiner says. 'With increasing numbers of offspring conceived after fertility treatments, it is important to follow up on their health.'

Contact: Andrew Lavin
American Associates, Ben-Gurion University of the Negev

Public Release: 25-Apr-2017
Journal of the American Chemical Society
Understanding the correct architectures of IMM proteins
A new study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST), developed a new technique to understand the correct architectures of IMM proteins, using special chemical tools.
Korea Health Technology R&D Project/Korea Health Industry Development Institute, Ministry of Health & Welfare of Korea

Contact: JooHyeon Heo
Ulsan National Institute of Science and Technology(UNIST)

Public Release: 25-Apr-2017
Nature Communications
Studying a catalyst for blood cancers
Researchers at Sylvester today published a paper in the prestigious journal Nature Communications, which describes how TET2 loss can open the door for mutations that drive myeloid, lymphoid, and other cancers.

Contact: Patrick Bartosch
University of Miami Miller School of Medicine

Public Release: 25-Apr-2017
Patients with positive fecal screening test, sooner is better for colonoscopy
The risk of colorectal cancer increased significantly when colonoscopy was delayed by more than nine months following a positive fecal screening test, according to a large Kaiser Permanente study published today in the Journal of the American Medical Association.

Contact: Heather Platisha
Kaiser Permanente

Public Release: 25-Apr-2017
Cell Reports
Environmental enrichment triggers mouse wound repair response
Living in a stimulating environment has a wide range of health benefits in humans and has even been shown to fight cancer in mice, but the underlying mechanisms have been unclear. A study published April 25 in Cell Reports reveals that cognitive stimulation, social interactions, and physical activity increase lifespan in mice with colon cancer by triggering the body's wound repair response.

Contact: Joseph Caputo
Cell Press

Public Release: 25-Apr-2017
Potential new treatment for kidney failure in cancer patients
Kidney dysfunction is a frequent complication affecting more than 50 percent of all cancer patients, and is directly linked to poor survival. Despite the high occurrence, it is still not clear how presence of a tumor contributes to kidney dysfunction and how this can be prevented. A new study from researchers at Uppsala University shows that kidney dysfunction can be caused by the patient's own immune system, 'tricked' by the tumor to become activated.

Contact: Anna-Karin Olsson
Uppsala University

Public Release: 25-Apr-2017
Translational Psychiatry
Chemotherapy drug may increase vulnerability to depression
A chemotherapy drug used to treat brain cancer may increase vulnerability to depression by stopping new brain cells from growing, according to a new King's College London study out today in Translational Psychiatry.

Contact: Jack Stonebridge
King's College London

Public Release: 25-Apr-2017
ELCC 2017 European Lung Cancer Conference
Annual flu jab may pose greater risk for lung cancer patients under immunotherapy
Lung cancer patients treated with PD-1/PD-L1 checkpoint inhibitors may be at increased risk of adverse events after receiving the seasonal influenza vaccination, according to the first study measuring this effect.

Contact: Jackie Partarrieu
European Society for Medical Oncology

Public Release: 25-Apr-2017
Journal of Experimental Botany
Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli
In the quest for less contaminating fertilizing strategies, a study by the UPV/EHU has explored the use of ammonium-based fertilizers, less widely used than the nitrate for fertilizing owing to the reduced growth displayed by the plants. The comparison between these two sources of nitrogen has revealed a higher amount of glucosinolates in the case of ammonium nutrition. This gives the plants greater insecticidal capacity and this is of great interest nutritionally as these are anticarcinogenic substances.

Contact: Matxalen Sotillo
University of the Basque Country

Public Release: 25-Apr-2017
2017 ASCO Annual Meeting
TGen-HonorHealth study: High rate of tumor shrinkage among pancreatic cancer patients
Adding cisplatin to standard gemcitabine/nab-paclitaxel drug treatment provided a very high rate of tumor shrinkage for patients with advanced pancreatic cancer, according to the results of a pilot clinical trial conducted by the HonorHealth Research Institute and the Translational Genomics Research Institute (TGen). These statistically significant and clinically meaningful improvements in overall response and survival rates resulted from a phase Ib/II clinical study performed at the HonorHealth Research Institute, a partnership of HonorHealth and TGen.
Stand Up To Cancer, Mattress Firm, Arizona Diamondbacks, and Seena Magowitz Foundation

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 25-Apr-2017
Urology Practice
Prostate cancer patients would pay $2,000 for more accurate biopsies, Loyola study finds
Prostate cancer patients are willing to pay up to $2,000 of their own money for a new high-tech biopsy technique that significantly improves accuracy, according to a study published in the journal Urology Practice.

Contact: Jim Ritter
Loyola University Health System

Public Release: 25-Apr-2017
New method for early screening of colorectal cancer
A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan. Shimadzu Corporation, the Kobe University Graduate School of Medicine, and the National Cancer Center in Japan have collaborated to develop a new screening method that comprehensively analyzes the metabolites in our blood.
Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science

Contact: Eleanor Wyllie
Kobe University

Public Release: 25-Apr-2017
Higher costs for complex cancer surgery indicator for worse care
Higher costs for complex cancer surgery may be an indicator for worse -- rather than better -- quality of care, according to new research by experts at Rice University and the University of Texas MD Anderson Cancer Center. Their findings are published in the journal Surgery and provide multiple implications for care delivery.

Contact: Jeff Falk
Rice University

Public Release: 25-Apr-2017
Proceedings of the National Academy of Sciences
'Cyclops' algorithm spots daily rhythms in cells
Humans, like virtually all other complex organisms on Earth, have adapted to their planet's 24-hour cycle of sunlight and darkness. That circadian rhythm is reflected in human behavior, of course, but also in the molecular workings of our cells. Now scientists have developed a powerful tool for detecting and characterizing those molecular rhythms -- a tool that could have many new medical applications.
Defense Advanced Research Projects Agency, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute on Aging, and Penn Genome Frontiers Institute/Pennsylvania Department of Health

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 25-Apr-2017
ACS Environmental Science and Technology
College students exposed to toxic flame retardants in dust from dormitory furnishings
A new study shows that students living in college dormitories are exposed to high levels of toxic flame retardants in dust. In the analysis, led by Silent Spring Institute, scientists measured dozens of flame retardants in dorm dust samples, including carcinogens, hormone disruptors, and chemicals that affect brain function. The results also included some of the highest levels ever reported.
John Merck Fund, Hoffman Program on Chemicals and Health at the Harvard T.H. Chan School of Public Health, Fine Fund, Silent Spring Institute

Contact: Alexandra Goho
617-332-4288 x232
Silent Spring Institute

Public Release: 25-Apr-2017
Genes & Development
UVA finds way to speed search for cancer cures dramatically
A new technique will let a single cancer research lab do the work of dozens, dramatically accelerating the search for new treatments and cures. And the technique will benefit not just cancer research but research into every disease driven by gene mutations, from cystic fibrosis to Alzheimer's disease.
National Natural Science Foundation of China, Robert Wood Johnson Foundation, National Honor Scientist Program of Korea, Howard Hughes Medical Institute, National Institutes of Health

Contact: Josh Barney
University of Virginia Health System

Public Release: 25-Apr-2017
Health Psychology
Bad feelings can motivate cancer patients
Feeling down is a common side effect of being diagnosed with cancer. Anxiety, guilt, and distress often come hand-in-hand with diagnosis and treatment. But a recent study by researchers from Concordia and the University of Toronto shows that these seemingly negative emotions can actually be good for patients.

Contact: Marisa Lancione
Concordia University

Public Release: 25-Apr-2017
Journal of Bone Oncology
New guidance for management of aromatase-inhibitor related bone loss in breast cancer
Women treated with aromatase-inhibitors (AI) for breast cancer experience a two to four-fold increase in bone loss compared to the normal rate of bone loss with menopause -- and as a result they are at heightened risk of fracture. This new Position Statement, jointly published by seven international and European organizations, identifies fracture-related risk factors in these patients and outlines key management strategies to help prevent bone loss and fractures.

Contact: L. Misteli
International Osteoporosis Foundation

Public Release: 24-Apr-2017
Does the microbiome play a role in the effectiveness of colorectal cancer treatment?
A study by UMass Medical School shows that C. elegans, fed a diet of E. coli bacteria, are 100 times more sensitive to the chemotherapy drug floxuridine, commonly used to treat colon cancer, than worms fed different bacteria. These findings suggest that the bacteria residing in your digestive tract may play an important role in your ability to respond to chemotherapy.

Contact: Jim Fessenden
University of Massachusetts Medical School

Showing releases 1-25 out of 1338.

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