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Public Release: 27-Oct-2016
Cell Chemical Biology
3-D tumors grown in the lab provide new perspective for cancer drug discovery
Understanding how cells within tumors respond to drugs is a critical issue in anticancer drug development. In an article published in Cell Chemical Biology researchers from Uppsala University report a new approach to study cancer cells' reactions to treatments and present how it can be used to find new promising drug combinations.

Contact: Mårten Fryknäs
Uppsala University

Public Release: 27-Oct-2016
Promising blood test fails to yield clues about strategies for bladder cancer treatment
A blood test that has shown promise in predicting how cancer will progress and what treatments will be most effective for a given patient may not be reliable for either, according to a new Penn Medicine study published this week in Cancer, a peer-reviewed journal of the American Cancer Society.

Contact: John Infanti
University of Pennsylvania School of Medicine

Public Release: 27-Oct-2016
Study yields rich dossier of cancer-linked protein's associates
By developing an atomic-scale picture of how the cancer-linked enzyme PP2A binds to other proteins, Brown University researchers have developed a new list of nearly 100 of its potential partners.
National Institutes of Health, Fund for Scientific Research Flanders, Flemish Concerted Research Action

Contact: David Orenstein
Brown University

Public Release: 27-Oct-2016
Stability of exhausted T cells limits durability of cancer checkpoint drugs
Researchers found that reinvigorating exhausted T cells in mice using a PD-L1 blockade caused very few T memory cells to develop. After the blockade, re-invigorated T cells became re-exhausted if antigen from the virus remained high, and failed to become memory T cells when the virus was cleared.
Robertson Foundation/Cancer Research Institute Irvington Fellowship, American Cancer Society Postdoctoral Fellowship, German Research Foundation Fellowship National Institutes of Health, Parker Institute for Cancer Immunotherapy

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 27-Oct-2016
Supercomputing the p53 Protein as a promising anticancer therapy
Using supercomputing to model the largest atomic level system of the tumor suppression protein p53 to date -- over 1.5 million atoms.
National Science Foundation

Contact: Faith Singer-Villalobos
University of Texas at Austin, Texas Advanced Computing Center

Public Release: 27-Oct-2016
Research into basic workings of immune system points to way of improving therapies for cancer
In a paper posted online today by the journal Science, researchers at the Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that, in mice with chronic viral infection, exhausted T cells are controlled by a fundamentally different set of molecular circuits than T cells effectively battling infections or cancer - a finding that suggests a way to increase the staying power of CAR T cells, a promising form of immunotherapy for cancer.
National Institutes of Health

Contact: John Noble
Dana-Farber Cancer Institute

Public Release: 27-Oct-2016
JAMA Oncology
Prognostic role of side where colon cancer occurs
Does the location of colon cancer -- left or right side -- matter for survival? A new report published online by JAMA Oncology reviewed medical literature to examine the prognostic role of a primary colon cancer tumor being located on the left vs. right side.

Contact: Fausto Petrelli, M.D.
The JAMA Network Journals

Public Release: 27-Oct-2016
Cancer Cell
Antibody breaks leukemia's hold, providing new therapeutic approach
Acute myeloid leukemia (AML) is an aggressive cancer known for drug resistance and relapse. In an effort to uncover new treatment strategies, researchers at University of California San Diego School of Medicine and Moores Cancer Center discovered that a cell surface molecule known as CD98 promotes AML. The study also shows that inhibiting CD98 with the therapeutic antibody IGN523 blocks AML growth in patient-derived cells and mouse models.
National Institutes of Health, Lymphoma and Leukemia Society, National Cancer Center, Japanese Society for the Promotion of Science, Arthritis Foundation, Melanoma Research Alliance

Contact: Heather Buschman
University of California - San Diego

Public Release: 27-Oct-2016
Nature Communications
Scientists develop 'world-first' 3-D mammary gland model
A team of researchers from Cardiff University and Monash Biomedicine Discovery Institute has succeeded in creating a 3-D mammary gland model that will pave the way for a better understanding of the mechanisms of breast cancer.

Contact: Julia Short
Cardiff University

Public Release: 27-Oct-2016
BMC Genomics
With cancer genome sequencing, be your own control
University of Colorado Cancer Center study shows that mapping cancer cells to published reference genomes is less accurate than mapping them to genomes of healthy cells from same subject.

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 27-Oct-2016
50-year-old bacteria could be alternative treatment option for cancer
Salmonella has a unique characteristic that allows the bacteria to penetrate through cell barriers and replicate inside its host. Now, scientists at the Cancer Research Center and the University of Missouri have developed a non-toxic strain of Salmonella to penetrate and target cancer cells. Results from this study could lead to promising new treatments that actively target and control the spread of cancer.
Cancer Research Center

Contact: Jeff Sossamon
University of Missouri-Columbia

Public Release: 27-Oct-2016
Cell Reports
Promise of better targeted treatments now possible in children's brain cancer
More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer. Writing this week in the journal Cell Reports, researchers at Huntsman Cancer Institute (HCI) at the University of Utah report they have identified an existing group of drugs that appear to reduce or eliminate a certain subgroup of childhood brain cancers while sparing normal brain tissue.
National Institutes of Health, Canadian Institute of Health Research, American Cancer Society, Huntsman Cancer Foundation

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 26-Oct-2016
Mutations in bone cells can drive leukemia in neighboring stem cells
DNA mutations in bone cells that support blood development can drive leukemia formation in nearby blood stem cells. This neighbor cell effect was observed in a mouse model of Noonan syndrome. In mice, drugs can stop the effect and potentially could combat leukemia progression/recurrence.
NIH/National Heart Lung and Blood Institute, NIH/National Institute for Diabetes and Digestive and Kidney Diseases

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 26-Oct-2016
Self-renewable cancer killer cells could be key to making immunotherapy work
A small molecule that can turn short-lived 'killer T-cells' into long-lived, renewable cells that can last in the body for a longer period of time, activating when necessary to destroy tumor cells, could help make cell-based immunotherapy a realistic prospect to treat cancer.
Wellcome Trust

Contact: Craig Brierley
University of Cambridge

Public Release: 26-Oct-2016
ACS Nano
Imaging where cancer drugs go in the body could improve treatment
Nanomedicine has the potential to help personalize cancer treatments and reduce side effects of therapeutic drugs. While some progress has been made toward the latter goal, customized treatments are still hard to come by. Now scientists report in the journal ACS Nano a new step toward seeing where certain cancer drugs accumulate in the body in order to better treat patients. They tested their drug-carrying, lipid-based nanoparticles in animals.

Contact: Michael Bernstein
American Chemical Society

Public Release: 26-Oct-2016
Journal of the American College of Surgeons
Older and younger women benefit equally from breast reconstruction after mastectomy
The most comprehensive study of its kind to date found that older women enjoy the same benefits from breast reconstruction following mastectomy for breast cancer as younger women without a significant increase in the risk for complications.
NIH/National Cancer Institute

Contact: Devin Rose
American College of Surgeons

Public Release: 26-Oct-2016
Current Biology
Scripps Florida team illuminates molecular player in morphine addiction and rare disease
In a remarkable 'two for one' discovery, scientists from the Florida campus of The Scripps Research Institute (TSRI) have illuminated a key molecular player in the addictive effects of morphine in animal models.
National Institutes of Health, US Department of Defense

Contact: Eric Sauter
Scripps Research Institute

Public Release: 26-Oct-2016
Telerehabilitation through Internet ameliorate the life of women suffering breast cancer
Researchers from the University of Granada (UGR) and from hospitals Virgen de las Nieves and San Cecilio (Granada) have proved that telerehabilitation (rehabilitation with the help of the Internet, using the application Skype as a control platform) may help to alleviate the side effects associated with breast cancer and its treatment, like pain, fatigue, strength loss, deterioration of the quality of life, etc.

Contact: Noelia Galiano Castillo
University of Granada

Public Release: 26-Oct-2016
American Society of Hematology
Clinical Oncology
Mayo Clinic study shows that choice of medical center impacts life expectancy of multiple myeloma patients
People diagnosed with multiple myeloma are more likely to live longer if they are treated at a medical center that sees many patients with this blood cancer. Mayo Clinic researchers published these findings today in the Journal of Clinical Oncology.
Mayo Clinic, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery

Contact: Elizabeth Zimmermann Young
Mayo Clinic

Public Release: 26-Oct-2016
ACS Nano
How nanoscience will improve our health and lives in the coming years
Nanoscience research involves molecules 100 times smaller than cancer cells with the potential to profoundly improve the quality of our health and our lives. Now nine prominent nanoscientists look ahead to what we can expect in the coming decade, and conclude that nanoscience is poised to make important contributions in many areas, including health care, electronics, energy, food and water.

Contact: Stuart Wolpert
University of California - Los Angeles

Public Release: 26-Oct-2016
American Journal of Preventive Medicine
Georgia State finds perception of e-cigarette harm growing among US adults
The proportion of American adults who perceive e-cigarettes to be equally or more harmful than traditional cigarettes has tripled over the last few years, highlighting the need for more accurate public health messaging, according to a study led by tobacco researchers in the School of Public Health at Georgia State University.
NIH/National Institute of Drug Abuse, FDA Center for Tobacco Products

Contact: Anna Varela
Georgia State University

Public Release: 25-Oct-2016
Nature Biotechnology
Quantum leap in the reliability of mass spectrometry-based proteomics
Modern mass spectrometry systems enable scientists to routinely determine the quantitative composition of cells or tissue samples. However, different analysis software packages often produce different results from the same raw data. An international team of researchers led by Professor Stefan Tenzer from the Mainz University Medical Center has now addressed this problem by comparing and modifying various analysis software packages to ensure that the different software solutions produce consistent results.

Contact: Dr. Stefan Tenzer
Johannes Gutenberg Universitaet Mainz

Public Release: 25-Oct-2016
Journal of Proteome Research
Fat in feces points to early presence of colorectal cancer
Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer.

Contact: Herbert Hill, WSU Department of Chemistry
Washington State University

Public Release: 25-Oct-2016
Terminally ill cancer patients fare poorly after surgery
Patients with disseminated advanced cancer who undergo surgery are far more likely to endure long hospital stays and readmissions, referrals to extended care facilities and death, UC Davis researchers have found.

Contact: Dorsey Griffith
University of California - Davis Health System

Public Release: 25-Oct-2016
High levels of estrogen in lung tissue related to lung cancer in postmenopausal women
Researchers from Kumamoto University, Japan have found that postmenopausal women with multicentric adenocarcinoma of the lung have a higher concentration of estrogen in non-cancerous areas of the peripheral lung than similar women diagnosed with single tumor lung cancer. The research is an extension of their previous investigation into a gene mutation found to be related to an increased risk of multicentric lung cancer.
Japanese Grant-in-Aid for Scientific Research from MEXT, Smoking Research Foundation

Contact: J. Sanderson, N. Fukuda
Kumamoto University

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