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Public Release: 23-Feb-2017
Clinical Cancer Research
PI3K/mTOR inhibitors may be effective against some uterine sarcomas
The protein P-S6S240 may serve as an indicator of poor prognosis for patients with a hard-to-treat type of uterine sarcoma called leiomyosarcoma, and preclinical data suggest that patients whose tumors have this protein may respond to PI3K/mTOR inhibitors.
Prague's biobanking grant project, Swedish Labour Market Insurance and Swedish Medical Research Council, Western Norway Regional Health Authority (Helse Vest RHF), Norwegian Cancer Society, Norwegian Research Council

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 23-Feb-2017
Molecular Cell
Study reveals PGK1 enzyme as therapeutic target for deadliest brain cancer
Discovery of a dual role played by the enzyme phosphoglycerate kinase 1 (PGK1) may indicate a new therapeutic target for glioblastoma, an often fatal form of brain cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 23-Feb-2017
Journal of Experimental Medicine
Why is pancreatic cancer so hard to treat? Stroma provides new clues
Why are pancreatic tumors so resistant to treatment? One reason is that the 'wound'-like tissue that surrounds the tumors, called stroma, is so dense, likely preventing cancer-killing drugs from reaching the tumor. A team has now discovered heterogeneity in the fibroblast portion of the stroma, opening up the possibility of targeted treatment.
Cold Spring Harbor Cancer Center Support Grant, NIH/National Cancer Institute, The Lustgarten Foundation, Cold Spring Harbor Laboratory Association, National Institutes of Health

Contact: Peter Tarr
Cold Spring Harbor Laboratory

Public Release: 23-Feb-2017
PLOS Computational Biology
Novel mutation may be linked to prostate cancer in African-American men
Researchers have identified a novel mutation that may be associated with prostate cancer in African-American men, according to a new study published in PLOS Computational Biology. Scientists have long known that a huge variety of DNA mutations can lead to cancer. Some proteins can repair DNA mutations, but when repair proteins are mutated themselves, cancer may arise. Knowing which mutations are linked to which cancer types helps scientists develop new targeted treatments and detection strategies.

Contact: G. Andrés Cisneros

Public Release: 23-Feb-2017
Nicotinamide riboside (vitamin B3) prevents nerve pain caused by cancer drugs
A new study in rats suggests that nicotinamide riboside (NR), a form of vitamin B3, may be useful for treating or preventing nerve pain (neuropathy) caused by chemotherapy drugs. The findings by researchers at the University of Iowa were published recently in the Journal of the International Association for the Study of Pain (PAIN) and lay the groundwork for testing whether this nutritional supplement can reduce nerve pain in cancer patients receiving chemotherapy.
The Roy J. Carver Trust

Contact: Jennifer Brown
University of Iowa Health Care

Public Release: 23-Feb-2017
Clinical Cancer Research
Anti-aging gene identified as a promising therapeutic target for older melanoma patients
Scientists at The Wistar Institute have shown that an anti-diabetic drug can inhibit the growth of melanoma in older patients by activating an anti-aging gene that in turn inhibits a protein involved in metastatic progression and resistance to targeted therapies for the disease.
Melanoma Research Foundation, American Cancer Society, Miriam and Sheldon Adelson Research Foundation, Ira Brind Associate Professorship

Contact: Darien Sutton
The Wistar Institute

Public Release: 23-Feb-2017
International Journal of Cancer
Tumor protein could hold key to pancreatic cancer survival
A diagnosis of pancreatic cancer is often a death sentence because current chemotherapies have little impact on the disease.

Contact: Annie Rahilly
University of Melbourne

Public Release: 23-Feb-2017
Gene mutations cause leukemia, but which ones?
Watanabe-Smith's research, published today in the journal Oncotarget, sought to better understand one 'typo' in a standard leukemia assay, or test. While studying cancer biology and completing his doctorate in the lab of Brian Druker, M.D., at the OHSU Knight Cancer Institute, Watanabe-Smith encountered a new problem: an issue with the model system itself.

Contact: Amanda Gibbs
Oregon Health & Science University

Public Release: 23-Feb-2017
Nature Methods
New gene sequencing software could aid in early detection, treatment of cancer
A research team from the United States and Canada has developed and successfully tested new computational software that determines whether a human DNA sample includes an epigenetic add-on linked to cancer and other adverse health conditions.
Johns Hopkins University, Ontario Institute for Cancer Research, Ontario Ministry of Research, Innovation and Science

Contact: Phil Sneiderman
Johns Hopkins University

Public Release: 23-Feb-2017
Researchers uncover a role for HSP90 in gene-environment interactions in humans
Researchers at the Whitehead Institute have now uncovered a role for the protein-folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant proteins. And these effects of HSP90 can alter the course of human diseases.
Fanconi Anemia Research Fund, US Department of Defense, Harold and Leila Y. Mathers Foundation, National Institutes of Health, European Molecular Biology Organization, Human Frontier Science Program

Contact: Nicole Giese Rura
Whitehead Institute for Biomedical Research

Public Release: 23-Feb-2017
Molecular Cell
PERK protein opens line of communication between inside and outside of the cell
PERK is known to detect protein folding errors in the cell. Researchers at the Laboratory of Cell Death Research & Therapy at KU Leuven (University of Leuven, Belgium) have now revealed a hidden perk: the protein also coordinates the communication between the inside and the outside of the cell. These findings open up new avenues for further research into treatments for cancer, Alzheimer's, and diabetes.
Research Foundation Flanders, TrainERS/Horizon 2020, Innovation by Science and Technology

Contact: Patrizia Agostinis
KU Leuven

Public Release: 23-Feb-2017
Human Gene Therapy
AAV gene delivery vectors and cancer -- The debate continues
Overwhelming evidence from the biomedical literature shows that adeno-associated virus 2 (AAV2), a viral vector often used to deliver therapeutic genes, is not associated with cancer and, in fact, may protect against cancer.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 22-Feb-2017
Incarceration linked to excess burden of cancer, new study finds
People who spend time in jails and prisons are more likely to develop certain types of cancer than the general population in Ontario, according to a study published today in the open-access journal PLOS ONE. They were also more than 50 percent more likely to die from cancer than the general population in Ontario, the study found.

Contact: Kelly O'Brien
St. Michael's Hospital

Public Release: 22-Feb-2017
Nature study suggests new therapy for Gaucher disease
Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher, and maybe other lysosomal storage diseases, as a possible treatment with fewer risks and lower costs than current therapies. Reporting their data Feb. 22, the international research team conducted the study in mouse models of lysosomal storage disease and in cells from blood samples donated by people with Gaucher disease.

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 22-Feb-2017
Clinical Cancer Research
Measuring patients' muscles to predict chemotherapy side effects
Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center report in the journal Clinical Cancer Research that measuring patients' muscle mass and quality could potentially help doctors better identify patients at high risk for toxic side effects that could require hospitalizations.

Contact: Laura Oleniacz
UNC Lineberger Comprehensive Cancer Center

Public Release: 22-Feb-2017
Cell Reports
Scientists identify chain reaction that shields breast cancer stem cells from chemotherapy
Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.
US Department of Defense, American Cancer Society

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 22-Feb-2017
CAR T cells more powerful when built with CRISPR, MSK researchers find
Researchers from Memorial Sloan Kettering Cancer Center have harnessed the power of CRISPR/Cas9 to create more-potent chimeric antigen receptor (CAR) T cells that enhance tumor rejection in mice.
Lake Road Foundation, Mr. William H. and Mrs. Alice Goodwin, Commonwealth Foundation for Cancer Research, Stand Up To Cancer, American Association for Cancer Research, Lymphoma and Leukemia Society, NYSTEM, NIH/National Cancer Institute

Contact: Caitlin Hool
Memorial Sloan Kettering Cancer Center

Public Release: 21-Feb-2017
Proceedings of the National Academy of Sciences
Penn/Wistar study finds 'sweet spot' where tissue stiffness drives cancer's spread
Researchers from the University of Pennsylvania and The Wistar Institute have now found that physical forces exerted between cancer cells and the ECM are enough to drive a shape change necessary for metastasis. Those forces converge on an optimal stiffness that allows cancer cells to spread.
NIH/National Cancer Institute, National Institutes of Health, National Science Foundation

Contact: Evan Lerner
University of Pennsylvania

Public Release: 21-Feb-2017
Cancer Research
Prostate cancer cells grow with malfunction of cholesterol control in cells
Advanced prostate cancer and high blood cholesterol have long been known to be connected, but it has been a chicken-or-egg problem. Now a team led by researchers at the Duke Cancer Institute have identified a cellular process that cancer cells hijack to hoard cholesterol and fuel their growth. Identifying this process could inform the development of better ways to control cholesterol accumulation in tumors, potentially leading to improved survival for prostate cancer patients.
National Institutes of Health, Stewart Rahr Prostate Cancer Foundation Young Investigator Award, Department of Defense

Contact: Sarah Avery
Duke University Medical Center

Public Release: 21-Feb-2017
American Journal of Preventive Medicine
E-cigarettes popular among smokers with existing illnesses
In the US more than 16 million people with smoking-related illnesses continue to use cigarettes. According to a new study in the American Journal of Preventive Medicine, current and former smokers who suffer from disease are more likely to have reported using an e-cigarette, meaning these patients may see e-cigarettes as safer or less harmful than combustible cigarettes and a way to reduce the risks posed by traditional smoking.
National Institute on Drug Abuse, NIH/National Heart Lung and Blood Institute

Contact: Jillian B. Morgan
Elsevier Health Sciences

Public Release: 21-Feb-2017
Nature Communications
Discovery of a new gene critical in the development of lung and pancreatic cancers
Researchers at the Center for Applied Medical Research (CIMA) of the University of Navarra (Spain) have identified a critical gene, FOSL1, in the development of lung and pancreatic cancer. The work, published in Nature Communications, shows that the inhibition of FOSL1 brings about a great reduction in the size of the tumors in the lungs and pancreas. Thus, the results present this gene as a new molecular target to which new drugs should be directed.

Contact: Miriam Salcedo
Universidad de Navarra

Public Release: 21-Feb-2017
Molecular Therapy - Oncolytics
Using a rabbit virus to treat multiple myeloma
Treating multiple myeloma (MM) with myxoma virus (MYXV) eliminated a majority of malignant cells in preclinical studies, report investigators at the Medical University of South Carolina (MUSC) and elsewhere in an article published online on Dec. 7, 2016 by Molecular Therapy -- Oncolytics. Furthermore, introduction of MYXV had no impact on the bone marrow compartment and elicited a strong immune response that eradicated disease in some animals.
NIH/National Institute of Allergy and Infectious Diseases,NIH/National Cancer Institute, American Cancer Society, Hollings Cancer Center's Cancer Center, South Carolina Clinical and Translational Research Institute

Contact: Heather Woolwine
Medical University of South Carolina

Public Release: 21-Feb-2017
Journal of Clinical Oncology
Hormonal maintenance therapy may improve survival in women with chemo-resistant rare ovarian or peri
For women with a rare subtype of epithelial ovarian or peritoneum cancer, known as low-grade serous carcinoma (LGSC), hormone maintenance therapy (HMT) may significantly improve survival, according to a new study from researchers at The University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
University of Texas M. D. Anderson Cancer Center

Public Release: 21-Feb-2017
British Journal of Nutrition
Unlocking the heart-protective benefits of soy
A product of digesting a micronutrient found in soy may hold the key to why some people seem to derive a heart-protective benefit from eating soy foods, while others do not. Japanese men who are able to produce equol -- a substance made by some types of "good" gut bacteria when they metabolize isoflavones (micronutrients found in dietary soy) -- have lower levels of a risk factor for heart disease than their counterparts who cannot produce it.
National Institutes of Health, Japanese Ministry of Education, Culture, Sports, Science and Technology, Pitt Public Health's Department of Epidemiology

Contact: Allison Hydzik
University of Pittsburgh Schools of the Health Sciences

Public Release: 21-Feb-2017
ASCO-Society for Immunotherapy in Cancer
Gut bacteria associated with cancer immunotherapy response in melanoma
Melanoma patients' response to a major form of immunotherapy is associated with the diversity and makeup of trillions of potential allies and enemies found in the digestive tract, researchers at The University of Texas MD Anderson Cancer Center report at the ASCO-Society for Immunotherapy in Cancer meeting in Orlando.

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Showing releases 1-25 out of 1269.

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