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Key: Meeting M      Journal J      Funder F

Showing releases 201-225 out of 945.

<< < 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 > >>

Public Release: 8-May-2017
Nature Genetics
Finding a new major gene expression regulator in fungi
Changing a single letter, or base, in an organism's genetic code impact its traits. Subtler changes can and do happen: in eukaryotes, one such modification involves adding a methyl group to base 6 of adenine (6mA). In Nature Genetics, researchers report the prevalence of 6mA modifications in the earliest branches of the fungal kingdom. This little-explored realm provides a repertoire of important and valuable gene products for DOE missions in bioenergy and environment.
DOE/Office of Science

Contact: David Gilbert
DOE/Joint Genome Institute

Public Release: 4-May-2017
BMC Biology
Researchers identify 6,500 genes that are expressed differently in men and women
Men and women differ in obvious and less obvious ways -- for example, in the prevalence of certain diseases or reactions to drugs. How are these connected to one's sex? Weizmann Institute of Science researchers recently uncovered thousands of human genes that are expressed -- copied out to make proteins -- differently in the two sexes.

Contact: Gizel Maimon
Weizmann Institute of Science

Public Release: 4-May-2017
JAMA Oncology
Large data set brings precision to breast cancer diagnosis and care
Although the odds of developing breast cancer are nearly identical for black and white women, black women are 42 percent more likely to die from the disease. A large, multi-institutional study, published on-line May 4, 2017, in JAMA Oncology, explores the germline genetic variations and tumor biological differences between black and white women with breast cancer.
NIH/National Cancer Institute, Breast Cancer Research Foundation, Susan G. Komen Foundation for the Cure, American Cancer Society, and US Department of Defense

Contact: John Easton
University of Chicago Medical Center

Public Release: 4-May-2017
American Journal of Human Genetics
Type 2 diabetes genetic mapping identifies new 'loci'
Scientists are closer to understanding the genetic causes of type 2 diabetes by identifying 111 new chromosome locations ('loci') on the human genome that indicate susceptibility to the disease, according to a UCL-led study in collaboration with Imperial College London.

Contact: Rebecca Caygill
University College London

Public Release: 4-May-2017
Atlases of immune cells surrounding tumors may guide immunotherapy
Two independent studies have begun mapping the connections between and identities of the thousands of immune cells surrounding human tumors. One research group, looking at kidney cancer, found that tumors with different clinical outcomes have unique immune cell profiles. These profiles can also estimate a cancer patient's prognosis. The other group, looking at lung cancer, showed that even early tumors have disturbed immune cell activity. Both papers, appearing May 4 in Cell.

Contact: Joseph Caputo
Cell Press

Public Release: 3-May-2017
Science Advances
Mysterious molecule's function in skin cancer identified
SBP researcher Ranjan Perera uncovered the M.O. of a mysterious molecule called SPRIGHTLY that acts as a hub for cancer-related genes in the nucleus. The study identified 'major' RNA binding partners -- genes already implicated in a variety of cancers. In a mouse model of melanoma, tumors with reduced SPRIGHTLY grew more slowly, indicating use as a therapeutic target or biomarker.
National Institutes of Health, Florida Department of Health

Contact: Deborah Robison
Sanford-Burnham Prebys Medical Discovery Institute

Public Release: 2-May-2017
TGen and UNC Lineberger studies help shed light on aggressive brain cancer
One study showed that mutations affect how cancer starts in glial cells -- brain cells that provide support and insulation for neurons -- and how those mutations affect the way cancer evolves from low-grade gliomas to full-blown high-grade glioblastomas, the most common and deadly of primary brain cancer. The other study showed how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways.
The Ben & Catherine Ivy Foundation, National Institutes of Health, US Department of Defense, UNC University Cancer Research Fund, Howard Hughes Medical Institute, Damon Runyon Cancer Research Foundation, American Brain Tumor Association

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 2-May-2017
Molecular Systems Biology
Deep learning helps scientists keep track of cell's inner parts
High throughput screens of image-based data allow a direct view of proteins' whereabouts in the cell but the lack of fast and accurate analysis tools has been a bottleneck. Scientists reveal DeepLoc, a deep learning algorithm that is faster and more accurate than the human eye and brings analysis time down from months to hours.
Canadian Institutes for Health Research, National Institutes of Health, Connaught Global Challenge Fund, Canadian Foundation for Innovation, Ministry of Research and Innovation

Contact: Jovana Drinjakovic
University of Toronto

Public Release: 2-May-2017
Molecular Psychiatry
Researchers create a roadmap of bipolar disorder and how it affects the brain
In the largest MRI study on patients with bipolar disorder, a global consortium published new research showing that people with the condition have differences in the brain regions that control inhibition and emotion. By revealing clear and consistent alterations in key brain regions, the findings offer insight to the underlying mechanisms of bipolar disorder. Lithium treatment was associated with less thinning of gray matter, which suggests a protective effect of this medication on the brain.
NIH/Big Data to Knowledge, Canadian Institutes of Health Research, Nova Scotia Health Research Foundation, Dalhousie Clinical Research Scholarship, Research Council of Norway, South East Norway Health Authority, Kristian Gerhard Jebsen

Contact: Zen Vuong
University of Southern California

Public Release: 2-May-2017
PLOS Medicine
Controlling the HIV epidemic: A progress report on efforts in sub-Saharan Africa
In a Research Article published in PLOS Medicine, Richard Hayes of the London School of Hygiene & Tropical Medicine, UK and colleagues report on a clinical trial evaluating an intervention to achieve universal HIV testing and treatment in Zambia. The authors estimate that, after one year, the overall proportion of people with HIV receiving antiretroviral treatment (ART) had increased from 44 percent to 61 percent.

Contact: Richard Hayes

Public Release: 1-May-2017
Dr. Neville Sanjana receives 2017 Melanoma Research Alliance Young Investigator Award
Dr. Sanjana's three-year grant was awarded for his research entitled 'A human T cell genetic screen for melanoma immunotherapy,' which aims to characterize genetic mutations that lead to immunotherapy resistance in melanoma.
Melanoma Research Alliance

Contact: Karen Zipern
New York Genome Center

Public Release: 1-May-2017
Nature Genetics
The gene that starts it all
EPFL scientists have discovered the protein that kick-starts gene expression in developing embryos.
Swiss National Science Foundation, Gebert-Rüf Foundation, European Research Council

Contact: Nik Papageorgiou
Ecole Polytechnique Fédérale de Lausanne

Public Release: 28-Apr-2017
$2.4 million grant funds new Biomedical Big Data to Knowledge Training Program
A new $2.4-million program, funded by grants from the US National Library of Medicine and Penn State University, establishes the Biomedical Big Data to Knowledge Training Program. Its mission is to train the next generation of data scientists in order to assure that the vast wealth of biomedical data resulting from significant scientific discoveries can be mined quickly and efficiently in order to achieve useful results for human health and healing.
National Institutes of Health, National Library of Medicine, Penn State University

Contact: Barbara K. Kennedy
Penn State

Public Release: 27-Apr-2017
Computational research details the activation mechanism of p38α
p38α is a protein involved in chronic inflammatory diseases and cancer, among other pathological conditions. Published in the journal eLife, the study provides a deeper understanding of the structure of this protein, thereby paving the way for the development of more effective inhibitors. These findings are the result of combining fundamental biological data using computational techniques.
Seventh Framework Programme, Engineering and Physical Sciences Research Council, European Research Council, Horizon 2020, Spanish Ministry of Economy, Industry and Competitiveness

Contact: Sònia Armengou
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 27-Apr-2017
A close look into the barley genome
An international consortium, with the participation of the Helmholtz Zentrum München, Plant Genome and Systems Biology Department (PGSB), has published methodologically significant data on the barley genome. Their findings are contributing to the development of resistant varieties. The publication appeared in Nature.

Contact: sonja opitz
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 27-Apr-2017
PLOS Computational Biology
Diabetes app forecasts blood sugar levels
Researchers have developed a personalized algorithm that predicts the impact of particular foods on an individual's blood sugar levels, according to a new study published in PLOS Computational Biology. The algorithm has been integrated into an app, Glucoracle, which will allow individuals with type 2 diabetes to keep a tighter rein on their glucose levels -- the key to preventing or controlling the major complications of a disease that affects 8 percent of Americans.

Contact: David Albers

Public Release: 25-Apr-2017
Rosetta online server that includes everyone
Scientists have developed computer algorithms that are clever enough to map out biomolecules' 3-D forms, or create entirely new ones, based on their DNA or RNA sequence. However, doing so requires powerful supercomputers and specialized software that can take advantage of them.
National Science Foundation

Contact: Faith Singer-Villalobos
University of Texas at Austin, Texas Advanced Computing Center

Public Release: 25-Apr-2017
Nature Biotechnology
New method to ensure reproducibility in computational experiments
Scientists at the Centre for Genomic Regulation (CRG) in Barcelona, Spain, have developed a workflow management system that prevents irreproducibility when analyzing large genomics datasets with computers. Nextflow contributes to establishing good scientific practices and provides an important framework for those research projects where the analysis of large datasets are used to take decisions, for example, in precision medicine.
Centre for Genomic Regulation, Spanish Plan Nacional, Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa 2013-2017', Elixir EXCELERATE project, H2020 European framework project OpenRiskNet, La Caixa Banking Foundation

Contact: Laia Cendros
Center for Genomic Regulation

Public Release: 25-Apr-2017
Biological Conservation
Extinction risk for many species vastly underestimated, study suggests
A new study indicates that the number of plant and animal species at risk of extinction may be considerably higher than previously thought. A team of researchers, however, believe they've come up with a formula that will help paint a more accurate picture.

Contact: Jessica Guenzel
Columbia University

Public Release: 25-Apr-2017
PLOS Biology
What's coming next? Scientists identify how the brain predicts speech
A new study, publishing on April 25 in the open access journal PLOS Biology, has shed light on how the brain helps us to predict what is coming next in speech.

Contact: Yuki Kikuchi

Public Release: 24-Apr-2017
Medical Image Analysis
Robot radiology: Low-cost AI could screen for cervical cancer better than humans
A result of 10 years work, Lehigh University's Sharon Xiaolei Huang and her team have created a cervical cancer screening technique that, based on an analysis of a very large dataset, has the potential to perform as well or better than human interpretation on other traditional screening results, such as Pap tests and HPV tests -- at a much lower cost. The technique could be used in less-developed countries, where 80 percent of deaths from cervical cancer occur.
National Institutes of Health, NIH/National Library of Medicine, Lister Hill National Center for Biomedical Communications

Contact: Lori Friedman
Lehigh University

Public Release: 20-Apr-2017
Recruitment begins for world's first ovarian cancer vaccine trial
UConn Health is beginning to recruit patients for the world's first personalized genomics-driven ovarian cancer vaccine clinical trial. The goal: to prevent an often deadly relapse of the disease in women diagnosed at advanced stages.

Contact: Lauren Woods
University of Connecticut

Public Release: 20-Apr-2017
Environmental 'memories' passed on for 14 generations
Scientists at the Centre for Genomic Regulation (CRG) in Barcelona and the Josep Carreras Leukaemia Research Institute and The Institute for Health Science Research Germans Trias i Pujol (IGTP) in Badalona, Spain, have discovered that the impact of environmental change can be passed on in the genes of tiny nematode worms for at least 14 generations -- the most that has ever been seen in animals. The findings will be published on Friday, April 21, in the journal Science.
European Research Council, Spanish Ministry of Economy and Competitiveness, AXA Research Fund, Bettencourt Schueller Foundation, Agència de Gestió d'Ajuts Universitaris

Contact: Laia Cendros
Center for Genomic Regulation

Public Release: 20-Apr-2017
Open-source mungbean genetic information website enables better varieties
Scientists and mungbean growers around the world now have access to an open-source website containing the latest genetic information on the qualities of 560 accessions of mungbean.

Contact: Niki Widdowson
Queensland University of Technology

Public Release: 20-Apr-2017
Nature Microbiology
Fungi have enormous potential for new antibiotics
Fungi are a potential goldmine for the production of pharmaceuticals. This is shown by researchers at Chalmers University of Technology, who have developed a method for finding new antibiotics from nature's own resources. The findings -- which could prove very useful in the battle against antibiotic resistance -- were recently published in the journal, Nature Microbiology.

Contact: Johanna Wilde
Chalmers University of Technology

Showing releases 201-225 out of 945.

<< < 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 > >>