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Bioinformatics

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Key: Meeting M      Journal J      Funder F

Showing releases 51-75 out of 970.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 > >>

Public Release: 21-Mar-2017
Molecular Metabolism
SIB accelerates the fight against diabetes with several pan-European projects
Recent advances in the fight against type 2 diabetes (T2D) result from a pan-European collaborative project, called IMIDIA, in which the SIB Swiss Institute of Bioinformatics is closely involved since 2010. SIB was in charge of both coordinating the large amount of patients' data (acting as Data Coordination Centre, DCC) as well as analysing the data to find biomarkers for early detection of the disease.

Contact: Maia Berman
maia.berman@sib.swiss
41-216-924-054
Swiss Institute of Bioinformatics

Public Release: 20-Mar-2017
Nature Methods
Gene editing technique helps find cancer's weak spots
Genetic mutations that cause cancer also weaken cancer cells, allowing researchers to develop drugs that will selectively kill them. This is called 'synthetic lethality' because the drug is only lethal to mutated (synthetic) cells. Researchers at UC San Diego School of Medicine and Jacobs School of Engineering developed a method to search for synthetic-lethal gene combinations. The technique, published March 20 in Nature Methods, uncovered 120 new opportunities for cancer drug development.
National Institutes of Health, Burroughs Wellcome Fund, March of Dimes Foundation, Sidney Kimmel Foundation, California Institute for Regenerative Medicine, UC San Diego Clinical and Translational Research Institute Grant

Contact: Heather Buschman
hbuschman@ucsd.edu
858-249-0456
University of California - San Diego

Public Release: 20-Mar-2017
Nature Methods
Data published in Nature Methods demonstrate breakthrough ability to accurately detect somatic single nucleotide variations in single cells
Before scientists can analyze the genome of a single cell, they must first obtain sufficient amounts of its DNA by whole genome amplification (WGA). But WGA typically produce errors that falsely indicate the presence of mutations and obscure the detection of any real somatic mutations. SingulOmics Corporation announced a Nature Methods publication demonstrating the game changing technology that enables accurate detection of somatic single nucleotide variations in single cells not possible in any prior methods.

Contact: Scott Rieger
srieger@accessirpr.com
619-994-5994
SingulOmics Corporation

Public Release: 20-Mar-2017
Proceedings of the National Academy of Sciences
Vaccine, improved treatment are keys to control of a surging HIV pandemic
Development and widespread use of a vaccine that's even partially effective against HIV, along with more progress toward diagnosis and treatment, offer the best hopes for turning the corner on a global pandemic that's still spiraling out of control, researchers reported today.
National Institutes of Health

Contact: Jan Medlock
jan.medlock@oregonstate.edu
541-737-6874
Oregon State University

Public Release: 17-Mar-2017
Scientific Reports
TGen study of ASU football team produces largest known dataset for concussion diagnostics
Following a three-year study of the Arizona State University football program, researchers at the Translational Genomics Research Institute have created the largest dataset to date of extracellular small RNAs, which are potential biomarkers for diagnosing medical conditions, including concussions. Details of the dataset were published today in Scientific Reports, an online open-access journal of the Nature Publishing Group.
Riddell Inc., Flinn Foundation, TGen Foundation

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute

Public Release: 16-Mar-2017
PLOS Computational Biology
A blood test for autism
An algorithm based on levels of metabolites found in a blood sample can accurately predict whether a child is on the autism spectrum of disorder (ASD), based upon a recent study.
National Institutes of Health

Contact: Mary Martialay
martim12@rpi.edu
Rensselaer Polytechnic Institute

Public Release: 16-Mar-2017
Proceedings of the National Academy of Sciences
Computer simulation of protein synthesis reveals awesome complexity of cell machinery
A Japanese research team led by Osaka University and Riken ran computer simulations of protein production. The model system, based on E. coli, contained the bare minimum for assembling proteins: 241 chemicals undergoing 968 reactions for 1,000 seconds. Many of these chemicals twice reached steady concentrations, only to be suddenly depleted at a later stage. The researchers believe the build-up and collapse of steady concentrations is characteristic of large-scale reactions, and vital for controlling the body's chemistry.
Japan Society for the Promotion of Science, Japan Science and Technology

Contact: Saori Obayashi
saori_obayashi@mail.osaka-u.ac.jp
81-661-055-886
Osaka University

Public Release: 15-Mar-2017
Applications in Plant Sciences
Better barcoding: New library of DNA sequences improves plant identification
Researchers from the Department of Environmental Science at Emory University have used publicly available data to develop a sequence library of the rbcL gene, a popular barcode in plants, for use in DNA metabarcoding studies. Using both the rbcL and an already developed ITS2 library improved the accuracy of species identification and will allow advances including improved assessments of nutritional supplements and monitoring of bee populations.
US Army Research Office

Contact: Beth Parada
apps@botany.org
Botanical Society of America

Public Release: 15-Mar-2017
Detecting blood clot risk using biomarkers
Researchers at Boston Medical Center (BMC) and Boston University School of Medicine (BUSM) aim to increase survival rates among these patients by identifying new and validating existing biomarkers.
NIH/National Cancer Institute

Contact: Tim Viall
timothy.viall@bmc.org
617-638-6857
Boston University Medical Center

Public Release: 15-Mar-2017
PLOS Biology
Luxembourg researchers decipher how the body controls stem cells
Stem cells are unspecialised cells that can develop into any type of cell in the human body. So far, however, scientists only partially understand how the body controls the fate of these all-rounders, and what factors decide whether a stem cell will differentiate, for example, into a blood, liver or nerve cell. Researchers from the University of Luxembourg and an international team have now identified an ingenious mechanism by which the body orchestrates the regeneration of red and white blood cells from progenitor cells.

Contact: Thomas Klein
thomas.klein@uni.lu
352-466-644-5148
University of Luxembourg

Public Release: 14-Mar-2017
Aging Cell
Benchmark database of lifespan-extending drugs announced
Scientists announced the benchmark database of lifespan-extending drugs encompassing 418 compounds with lifespan-extension data across 27 different model organisms, revealing that the majority of age-related pathways have yet to be targeted pharmacologically.
Wellcome Trust, Israel Ministry of Science and Technology

Contact: Charlotte Casebourne
casebourne@bg-rf.org.uk
Biogerontology Research Foundation

Public Release: 13-Mar-2017
Proceedings of the National Academy of Sciences
The controversial origin of a symbol of the American west
New research by Professor Beth Shapiro of the UC Santa Cruz Genomics Institute and University of Alberta Professor Duane Froese has identified North America's oldest bison fossils and helped construct a bison genealogy establishing that a common maternal ancestor arrived between 130,000 and 195,000 years ago, during a previous ice age.
Gordon and Betty Moore Foundation, National Science Foundation

Contact: Alexis Morgan
amorgan1@ucsc.edu
831-515-8142
University of California - Santa Cruz

Public Release: 13-Mar-2017
Research Ideas & Outcomes
Legitimacy of reusing images from scientific papers addressed
Scientific research builds on previous breakthroughs and publications, and yet access to data is often legally restricted. A recent paper by taxonomists and copyright experts published in the open science journal Research Ideas and Outcomes as part of the EU BON Collection, explores the application of copyright law and the reuse of published images as biodiversity data.

Contact: Donat Agosti
agosti@plazi.org
Pensoft Publishers

Public Release: 10-Mar-2017
CNIC coordinates an EU project to foster partnership between researchers in academia and industry
The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) coordinates an EU project to foster partnership between researchers in academia and industry. The 4DHeart project is underpinned by a €1.5 million budget spread over 4 years.
European Union

Contact: Fatima Lois
flois@cnic.es
34-639-282-477
Centro Nacional de Investigaciones Cardiovasculares

Public Release: 10-Mar-2017
Scientific Reports
Researchers find a gene that causes Opitz C syndrome
The study, published in the journal Scientific Reports, identifies the gene that causes Opitz C syndrome in the only patient diagnosed with this ultra-rare disorder in Catalonia, which affects only sixty people in the world. The identified mutation in the gene MAGEL2 coincides with the one seen in some patients with another minority disease, the Schaaf-Yang syndrome.
FECYT, Precipita

Contact: Laia Cendrós
laia.cendros@crg.eu
34-607-611-798
Center for Genomic Regulation

Public Release: 9-Mar-2017
New Phytologist
FRED database gathers root traits to advance understanding of below-ground plant ecology
Oak Ridge National Laboratory scientists have released a new global, centralized database of plant root traits, or identifying characteristics, that can advance our understanding of how the hidden structure of plants below ground may interact with and relate to life above ground.
US Department of Energy Office of Science

Contact: Stephanie G. Seay
seaysg@ornl.gov
865-576-9894
DOE/Oak Ridge National Laboratory

Public Release: 9-Mar-2017
Cell Stem Cell
The intestine has a reservoir of stem cells that are resistant to chemotherapy
Researchers at the IRB Barcelona headed by ICREA investigator Eduard Batlle, head of the Colorectal Cancer Laboratory, have discovered a new group of intestinal stem cells with very different characteristics to those of the abundant and active stem cells already known in this organ. The study has been published in Cell Stem Cell. These new group of stem cells are quiescent, that is to say, they do not proliferate and are apparently dormant.
European Research Council (ERC), Botín Foundation, Spanish Ministry of Science and Competitiveness

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 9-Mar-2017
Nature Protocols
Innovative technique greatly increases sensitivity of DNA sequencing
OICR researchers, together with international collaborators, have invented a technique to avoid a major problem with common laboratory techniques and improve the sensitivity of important cancer tests. The findings, recently published in the journal Nature Protocols, describe a process by which the sensitivity of DNA sequencing can be improved. The technology, called SiMSen-Seq, could aid in detecting the recurrence of cancers, catching possible disease relapses faster than current methods and improving patient outcomes.

Contact: Hal Costie
hal.costie@oicr.on.ca
647-260-7921
Ontario Institute for Cancer Research

Public Release: 8-Mar-2017
Proceedings of the National Academy of Sciences
New technology platform propels the use of 'organs-on-chips'
BWH has developed a novel technology platform that enables the continuous and automated monitoring of so-called 'organs-on-chips' -- tiny devices that incorporate living cells to mimic the biology of bona fide human organs.

Contact: Johanna Younghans
jyounghans@partners.org
617-525-6373
Brigham and Women's Hospital

Public Release: 8-Mar-2017
Scientific Reports
Uncovering new relationships and organizational principles in protein interaction networks
Proteins, those basic components of cells and tissues, carry out many biological functions by working with partners in networks. The dynamic nature of these networks -- where proteins interact with different partners at different times and in different cellular environments -- can present a challenge to scientists who study them.
Stowers Institute for Medical Research, NIH/National Institute of General Medical Sciences

Contact: Kim Bland
ksb@stowers.org
816-926-4015
Stowers Institute for Medical Research

Public Release: 8-Mar-2017
Nature
A three-dimensional map of the genome
Cells face a daunting task. They have to neatly pack a several meter-long thread of genetic material into a nucleus that measures only five micrometers across. This origami creates spatial interactions between genes and their switches, which can affect human health and disease. Now, an international team of scientists has devised a powerful new technique that 'maps' this three-dimensional geography of the entire genome. Their paper is published in Nature.

Contact: Vera Glaßer
vera.glasser@mdc-berlin.de
49-309-406-2120
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Public Release: 7-Mar-2017
Physiological Reviews
Moscow State University scientists reveal the secret of naked mole-rat longevity
The work provides strong arguments in support of new break-through hypothesis explaining the phenomenon of exceptional longevity of naked mole-rat (Heterocephalus glaber, an African rodent). According to the hypothesis these animals managed to slow down the process of individual development and it resulted in a dramatic increase of the period of youth and decelerated aging. A similar process has begun in humans as well.
Lomonosov Moscow State University, Russian Scientific Foundation

Contact: Maxim Skulachev
max@mitotech.ru
891-661-21864
Lomonosov Moscow State University

Public Release: 7-Mar-2017
Proceedings of the National Academy of Sciences
'Black swan' events strike animal populations
A new analysis by the University of Washington and Simon Fraser University is the first to document that 'black swan' events also occur in animal populations and usually manifest as massive, unexpected die-offs.
David H. Smith Conservation Research Fellowship, Natural Sciences and Engineering Research Council of Canada, Canada Research Chairs Program, Richard C. and Lois M. Worthington Endowed Professorship in Fisheries Management

Contact: Michelle Ma
mcma@uw.edu
206-543-2580
University of Washington

Public Release: 6-Mar-2017
Journal of The Royal Society Interface
Breakthrough in live coral imaging
Interdisciplinarity Scientists at University of Copenhagen (Denmark), University of Technology Sydney (Australia), and Oregon Health University (USA) have used a well-known biomedical imaging technique called optical coherence tomography (OCT) to obtain fascinating insights to the structural organization and dynamics of reef-building corals. Their results have just been published in the multidisciplinary Journal of the Royal Society Interface.

Contact: Michael Kühl
mkuhl@bio.ku.dk
45-40-47-63-04
Faculty of Science - University of Copenhagen

Public Release: 3-Mar-2017
Genome Biology
Revealing Aspergillus diversity for industrial applications
In a Feb. 14, 2017 study published in Genome Biology, an international team report sequencing the genomes of 10 novel Aspergillus species, which were compared with the eight other sequenced Aspergillus species. With this first ever genus-wide view, the international consortium found that Aspergillus has a greater genomic and functional diversity than previously understood, broadening the range of potential applications for the fungi considered one of the most important workhorses in the biotechnology.
Department of Energy Office of Science

Contact: Massie Ballon
mlballon@lbl.gov
DOE/Joint Genome Institute

Showing releases 51-75 out of 970.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 > >>