Public Release: 16-Oct-2017 SimPath licenses novel ORNL system for enhanced synthetic biology
SimPath has licensed a novel cloning system developed by the Department of Energy's Oak Ridge National Laboratory that generates and assembles the biological building blocks necessary to synthetically bioengineer new medicines and fuels.
US Department of Energy, Biological and Environmental Research, Genomic Science Program; ORNL's Technology Innovation Program
Public Release: 16-Oct-2017
Nature Communications Neutrons observe vitamin B6-dependent enzyme activity useful for drug development
Scientists at the Department of Energy's Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant tuberculosis, malaria and diabetes.
Specifically, the team used neutron crystallography to study the location of hydrogen atoms in aspartate aminotransferase, or AAT, an enzyme vital to the metabolism of certain amino acids.
Department of Energy's Office of Science, ORNL's Center for Structural Molecular Biology
Public Release: 11-Oct-2017
Nature Communications Tracking the viral parasites of giant viruses over time
In freshwater lakes, microbes regulate the flow of carbon and determine if the bodies of water serve as carbon sinks or carbon sources. Viruses exist amidst all bacteria, usually in a 10-fold excess and include virophages which live in giant viruses and use their machinery to replicate and spread. Reported in Nature Communications, researchers at The Ohio State University and the DOE Joint Genome Institute have effectively doubled the number of known virophages.
DOE/Office of Science
Public Release: 20-Sep-2017 Sandia Labs wins 5 regional technology transfer awards
Sandia National Laboratories won five awards from the 2017 Federal Laboratory Consortium for its work to develop and commercialize innovative technologies.
The annual FLC awards program recognizes federal laboratories and their industry partners for outstanding technology transfer achievements.
Public Release: 24-Aug-2017
PLOS ONE DNA detectives crack the case on biothreat look-alikes
Biological "detectives" are tracking down biothreats such as the bacteria that causes tularemia ("rabbit fever"), but they constantly face the challenge of avoiding false positives.
Public Release: 14-Aug-2017
EPJ Data Science Are your tweets feeling well?
A study finds opinion and emotion in tweets change when you get sick, a method that public health workers could use to monitor health trends.
Defense Threat Reduction Agency
Public Release: 9-Aug-2017
PLOS ONE Exposure to antimicrobials during development may cause irreversible outcomes
Lawrence Livermore National Laboratory scientists have discovered that exposure to environmental levels of triclocarban (TCC), an antibacterial chemical common in personal care products like soaps and lotions as well as in the medical field, can transfer from mother to offspring and interfere with lipid metabolism.
Public Release: 11-Jul-2017 Clean water that's 'just right' with Sandia sensor solution
Working with Parker Hannifin, Sandia National Laboratories combined basic research on an interesting form of carbon with a unique microsensor to make an easy-to-use, table-top tool that quickly and cheaply detects disinfection byproducts in our drinking water before it reaches consumers.
Public Release: 10-Jul-2017
Proceedings of the National Academy of Sciences New Berkeley lab algorithms extract biological structure from limited data
A new Berkeley Lab algorithmic framework called multi-tiered iterative phasing (M-TIP) utilizes advanced mathematical techniques to determine 3-D molecular structure of important nanoobjects like proteins and viruses from very sparse sets of noisy, single-particle data.
Public Release: 5-Jul-2017
Nature Climate Change Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2017
ORNL-led team integrates Earth systems with human impact data for climate predictions with fewer uncertainties; ORNL to develop secure platform to analyze large health datasets for Dept. of Veterans Affairs; ORNL neutrons used to resolve debate over origins of metallic glass behavior; ORNL studies 3-D printing materials that crosslink without heat; New web-based calculator by ORNL shows energy-savings potential of airtight buildings; ORNL combines 3-D printing with casting to produce multi-material, damage-tolerant components.
Department of Energy
Public Release: 28-Jun-2017
Scientific Reports What's on your skin? Archaea, that's what
It turns out your skin is crawling with single-celled microorganisms -- and they're not just bacteria. A study by the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the Medical University of Graz has found that the skin microbiome also contains archaea, a type of extreme-loving microbe, and that the amount of it varies with age.
Department of Energy, BioTechMed Graz, Bavaria California Technology Center, University of Regensburg
Public Release: 28-Jun-2017 Protein data takes significant step forward in medicine
Scientists at the Pacific Northwest National Laboratory and Oregon Health & Science University are part of a nationwide effort to learn more about the role of proteins in cancer biology and to use that information to benefit cancer patients.
NIH/National Cancer Institute
Public Release: 13-Jun-2017
Science Argonne X-rays used to help identify a key Lassa virus structure
Research done at Argonne National Laboratory's Advanced Photon Source was vital to the process of identifying the structure, which provides a guide for designing a Lassa virus vaccine. Lassa virus is endemic to Africa and kills thousands of people a year; it is particularly deadly for pregnant women.
Public Release: 31-May-2017
Science Advances Newly identified microbial process could reduce toxic methylmercury levels
A team led by the Department of Energy's Oak Ridge National Laboratory has identified a novel microbial process that can break down toxic methylmercury in the environment, a fundamental scientific discovery that could potentially reduce mercury toxicity levels and support health and risk assessments.
DOE/Office of Biological and Environmental Research
Public Release: 2-May-2017
Nature Communications Story tips from the Department of Energy's Oak Ridge National Laboratory, May 2017
Oak Ridge National Laboratory aids St. Jude's brain development research with software to speed processing of microscopy images; a bottleneck in the process to breakdown lignin for use in biofuels may occur at the plant cell wall's surface; predicting how ecosystems respond to environmental change could become more precise through new process sensitivity index method; through "quantum mechanical squeezing," researchers have conceptually designed a new method to increase the resolution of atomic force microscopy.
NIH/National Institute Of Neurological Disorders
Public Release: 25-Apr-2017
Scientific Reports Managing disease spread through accessible modeling
A new computer modeling study from Los Alamos National Laboratory is aimed at making epidemiological models more accessible and useful for public-health collaborators and improving disease-related decision making.
Defense Threat Reduction Agency
Public Release: 24-Apr-2017
Neuropsychologia Research from Sandia shows brain stimulation during training boosts performance
New research from Sandia published in Neuropsychologia shows that working memory training combined with a kind of noninvasive brain stimulation can lead to cognitive improvement under certain conditions. Improving working memory or cognitive strategies could be very valuable for training people faster and more efficiently.
Public Release: 17-Apr-2017
Nature Materials Tweaking a molecule's structure can send it down a different path to crystallization
Silky chocolate, a better medical drug, or solar panels all require the same thing: just the right crystals making up the material. Now, scientists trying to understand the paths crystals take as they form have been able to influence that path by modifying the starting ingredient.
US Department of Energy
Public Release: 10-Apr-2017
Nature Communications Researchers gain insight into protein critical to Zika virus reproduction
Berkeley Lab researchers collaborated with colleagues from the University of Indiana and Texas A&M University to solve the atomic structure of a Zika virus protein that is key to viral reproduction. The X-ray studies were conducted at the Advanced Light Source in the Berkeley Center for Structural Biology.
National Institutes of Health, Howard Hughes Medical Institute
Public Release: 6-Apr-2017
Science Discovered: Novel group of giant viruses
Viruses are thought to outnumber the microbes on Earth; both outnumber the stars in the Milky Way. A handful of giant viruses have been discovered in the past two decades, and in Science, DOE Joint Genome Institute scientists report a novel group of giant viruses with a more complete set of translation machinery genes than any other virus known to date. They believe that this discovery significantly increases our understanding of viral evolution.
DOE/Office of Science
Public Release: 5-Apr-2017
Nature X-ray study reveals long-sought insights into potential drug target
X-ray studies done in part at the Department of Energy's SLAC National Accelerator Laboratory have produced surprising insights into the workings of a hormone receptor associated with blood pressure regulation. Researchers believe it could be a target for new medicines related to cardiovascular conditions, neuropathic pain and tissue growth.
National Institutes of Health, National Science Foundation, DOE/Office of Science
The Department of Energy's Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time.