Public Release: 16-Jun-2016
Journal of Virology Sandia researchers discover mechanism for Rift Valley fever virus infection
Viruses can't live without us -- literally. As obligate parasites, viruses need a host cell to survive. Scientists are exploiting this characteristic by developing therapeutics that close off pathways necessary for viral infection, essentially stopping pathogens in their tracks.
Rift Valley fever virus and other bunyaviruses may soon be added to the list of viruses denied access to a human host. Sandia National Laboratories researchers have discovered a mechanism by which RVFV hijacks the host machinery to cause infection.
Public Release: 6-Jun-2016
Nature Chemical Biology Copper is key in burning fat
A new study led by a Berkeley Lab scientist and UC Berkeley professor establishes for the first time copper's role in fat metabolism, further burnishing the metal's reputation as an essential nutrient for human physiology.
National Institutes of Health
Public Release: 31-May-2016
Proceedings of the National Academy of Sciences RNA simulations boost understanding of retroviral diseases
New molecular dynamics research into how RNA folds into hairpin-shaped structures called tetraloops could provide important insights into new treatments for retroviral diseases.
Public Release: 27-May-2016
Nature Microbiology PNNL helps lead national microbiome initiative
Scientists Janet Jansson and Ljiljana Paša-Toli are part of a core group of scientists leading a national effort to understand communities of microorganisms and their role in climate science, food production and human health.
Public Release: 25-May-2016 Radiation 101: DoseNet delivers environmental data as an educational tool
A network of radiation-monitoring devices and a companion website and open-source code serve as educational and outreach tools for an international project called DoseNet that stretches from Northern California classrooms to a city hall in Japan. Its broad aim is to inform and connect students and communities using science and data as common ground.
Public Release: 20-May-2016
Angewandte Chemie Neutrons probe structure of enzyme critical to development of next-generation HIV drugs
A team led by the Department of Energy's Oak Ridge National Laboratory used neutron analysis to better understand a protein implicated in the replication of HIV, the retrovirus that causes AIDS. The enzyme, known as HIV-1 protease, is a key drug target for HIV and AIDS therapies. The multi-institutional team used neutron crystallography to uncover detailed interactions of hydrogen bonds at the enzyme's active site, revealing a pH-induced proton 'hopping' mechanism that guides its activity.
DOE/Office of Science
Public Release: 19-May-2016
Journal of Orthopaedic Research New research could personalize medicine for arthritis patients
Recently, a team of scientists from Lawrence Livermore National Laboratory, University of California, Davis, University of California, Merced and Regeneron Pharmaceuticals examined the whole-joint gene expression by RNA sequencing at one day, one, six and 12 weeks after injury. The team used a new, non-invasive tibial compression mouse model of PTOA, that mimics ACL rupture in humans from a single high-impact injury.
Public Release: 21-Mar-2016
ACS Nano ORNL-NIST team explores nanoscale objects and processes with microwave microscopy
Researchers at the Department of Energy's Oak Ridge National Laboratory and the National Institute of Standards and Technology have demonstrated a nondestructive way to observe nanoscale objects and processes in conditions simulating their normal operating environments. Their novel approach combines ultrathin membranes with microwaves and a scanning probe.
Department of Energy Office of Science, National Institute of Standards and Technology
Public Release: 21-Mar-2016
Analytical Chemistry Lighting up disease-carrying mosquitoes
Robert Meagher, a chemical engineer at Sandia National Laboratories, has developed a simple technique for simultaneously detecting RNA from West Nile and chikungunya virus in samples from mosquitoes. He is now working to add the ability to screen for Zika virus.
Public Release: 25-Feb-2016
Proceedings of the National Academy of Sciences Analyzing genetic tree sheds new light on disease outbreaks
Scientists have a new tool for unraveling the mysteries of how diseases such as HIV move through a population, thanks to insights into phylogenetics, the creation of an organism's genetic tree and evolutionary relationships.
Public Release: 8-Feb-2016
Nature Structural & Molecular Biology Scientists propose 'pumpjack' mechanism for splitting and copying DNA
New close-up images of the proteins that copy DNA inside the nucleus of a cell have led a team of scientists to propose a brand new mechanism for how this molecular machinery works. The scientists studied proteins from yeast cells, which share many features with the cells of complex organisms such as humans, and could offer new insight into ways that DNA replication can go awry.
National Institutes of Health, Howard Hughes Medical Institute, Brookhaven Lab Biology Department
Public Release: 28-Jan-2016 PNNL moves cybersecurity software and a novel disinfecting system beyond the lab
Software that helps cybersecurity analysts prevent hacks and a microbial disinfecting system that kills with an activated salt spray are two of the latest innovations Pacific Northwest National Laboratory has successfully commercialized with the help of business partners. The Federal Laboratory Consortium has honored the two teams with 2016 Excellence in Technology Transfer awards.
Department of Energy
Public Release: 26-Jan-2016
2015 GPU Technology Conference Titan targets tumors
Researchers at the German research laboratory Helmholtz-Zentrum Dresden Rossendorf are using Titan to understand and control new methods for particle acceleration that could have big impacts on laser-driven tumor removal.
Helmholtz-Zentrum Dresden-Rossendorf, US Department of Energy
Public Release: 16-Dec-2015
Nature Communications Diamonds may be the key to future NMR/MRI technologies
Berkeley Lab researchers have demonstrated that diamonds may hold the key to the future for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) technologies. NMR/MRI signals were significantly strengthened through the hyperpolarization of carbon-13 nuclei in diamond using microwaves.
US Department of Energy Office of Science
Public Release: 16-Dec-2015
Journal of Breast Cancer Research and Treatment New weapon in the fight against breast cancer
Berkeley Lab researchers have developed the first clinically-relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.
This model should be a powerful tool for testing therapies for aggressive ER+ breast cancers and for studying luminal cancers -- the most prevalent and deadliest forms of breast cancer.
NIH/National Cancer Institute
Public Release: 14-Dec-2015 Portable MRI named Top 10 Breakthrough of 2015 by Physics World magazine
Los Alamos National Laboratory's portable MRI was named one of the Top 10 Breakthroughs of the Year by Physics World, the member magazine of the Institute of Physics. Portable MRI, also called Battlefield MRI (bMRI), uses ultra-low-field magnetic resonance imaging to create images of injured soft tissues, such as the brain.
Public Release: 7-Dec-2015 A cure for medical researchers' big data headache
Oak Ridge Graph Analytics for Medical Innovation (ORiGAMI), supplies researchers with an advanced data tool for literature-based discovery that has the potential to accelerate medical research and discovery. The result of collaboration between Oak Ridge National Laboratory and the US National Library of Medicine, ORiGAMI unites three emerging technologies that are shaping the future of health care: big data, graph computing, and the Semantic Web.
Public Release: 7-Dec-2015
Scientific Reports New clues for battling botulism
Scientists have discovered new details about how 'cloaking' proteins protect the toxin that causes botulism, a fatal disease caused most commonly by consuming improperly canned foods. That knowledge and the cloaking proteins themselves might now be turned against the toxin -- the deadliest known to humankind.
Defense Threat Reduction Agency, National Institutes of Health, DOE Office of Science
The Department of Energy's Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time.