Public Release: 6-Apr-2017
Science Discovered: Novel group of giant viruses
Viruses are thought to outnumber the microbes on Earth; both outnumber the stars in the Milky Way. A handful of giant viruses have been discovered in the past two decades, and in Science, DOE Joint Genome Institute scientists report a novel group of giant viruses with a more complete set of translation machinery genes than any other virus known to date. They believe that this discovery significantly increases our understanding of viral evolution.
DOE/Office of Science
Public Release: 5-Apr-2017
Nature X-ray study reveals long-sought insights into potential drug target
X-ray studies done in part at the Department of Energy's SLAC National Accelerator Laboratory have produced surprising insights into the workings of a hormone receptor associated with blood pressure regulation. Researchers believe it could be a target for new medicines related to cardiovascular conditions, neuropathic pain and tissue growth.
National Institutes of Health, National Science Foundation, DOE/Office of Science
Public Release: 20-Mar-2017
Scientific Reports Testing for Zika virus: There's an app for that
Add rapid, mobile testing for Zika and other viruses to the list of things that smartphone technology is making possible. Researchers at Sandia National Laboratories have developed a smartphone-controlled, battery-operated diagnostic device that weighs under a pound, costs as little as $100 and can detect Zika, dengue and chikungunya within 30 minutes.
Public Release: 13-Feb-2017
Nature Microbiology Microbiomes more in flux in patients with inflammatory bowel disease
Patients with inflammatory bowel disease are more likely to see dramatic shifts in the make-up of the community of microbes in their gut than healthy people, according to the results of a study published in Nature Microbiology. The results help physicians and scientists understand the disease more fully and potentially offer new ways to track the disease and monitor patients.
National Institutes of Health, Crohn's and Colitis Foundation of America, Örebro University Hospital Research Foundation, Swedish Research Council
Public Release: 9-Feb-2017 Los Alamos research on cancer's origins key part of huge grant
Los Alamos National Laboratory researcher Ludmil Alexandrov has been announced as a member of one of the first four global research teams funded under Cancer Research UK's 'Grand Challenge,' which seeks to revolutionize the understanding of cancer and its prevention, diagnosis and treatment.
Cancer Research UK
Public Release: 3-Feb-2017
Scientific Reports Thirdhand smoke affects weight, blood cell development in mice
A new Berkeley Lab-led study found that the sticky residue left behind by tobacco smoke led to changes in weight and blood cell count in mice. These latest findings add to a growing body of evidence that thirdhand smoke exposure may be harmful.
University of California Tobacco-Related Disease Research Program
Public Release: 1-Feb-2017
Proceedings of the National Academy of Sciences Neutrons identify critical details in bacterial enzyme implicated in gastric cancer
Neutron analysis at the Department of Energy's Oak Ridge National Laboratory is helping researchers better understand a key enzyme found in a bacterium known to cause stomach cancer. Understanding the details of this enzyme, and thus the Helicobacter pylori bacteria's metabolism and biological pathways, could be central to developing drugs that act against H. pylori, but that do not attack the stomach's useful bacteria.
US Department of Energy, National Institutes of Health
Public Release: 18-Jan-2017 Grand Canyon rim-to-rim hikers provide data for Sandia study of health, performance
Sandia and the University of New Mexico researchers are collecting and study biometric data to determine if declines in physical or cognitive functions can predict a medical emergency for Grand Canyon hikers.
Called R2R WATCH, for Rim-to-Rim Wearables at the Canyon for Health, the study draws on the research team's expertise in biology and cognitive science.
Defense Threat Reduction Agency
Public Release: 29-Nov-2016
Applied Materials and Interfaces Glowing crystals can detect, cleanse contaminated drinking water
Motivated by public hazards associated with contaminated sources of drinking water, a team of scientists has successfully developed and tested tiny, glowing crystals that can detect and trap heavy-metal toxins like mercury and lead.
Public Release: 28-Nov-2016
Nature Microbiology Genes, early environment sculpt the gut microbiome
Genetics and birthplace have a big effect on the make-up of the microbial community in the gut, according to research published Nov. 28. in the journal Nature Microbiology. The findings by a team of scientists from two Department of Energy laboratories represent an attempt to untangle the forces that shape the gut microbiome, which plays an important role in keeping us healthy.
Office of Naval Research, DOE/Lawrence Berkeley National Laboratory
Public Release: 22-Nov-2016
Neuron Global brain initiatives generate tsunami of neuroscience data
New technologies are giving researchers unprecedented opportunities to explore how the brain processes, utilizes, stores and retrieves information. But, without a coherent strategy to analyze, manage and understand the data generated by these new tools, advancements in the field will be limited. Berkeley Lab researchers and their collaborators offer a plan to overcome these big data challenges.
Public Release: 17-Nov-2016
ACS Infectious Diseases Supercomputer simulations help develop new approach to fight antibiotic resistance
Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory have played a key role in discovering a new class of drug candidates that hold promise to combat antibiotic resistance. In a study led by the University of Oklahoma with ORNL, the University of Tennessee and Saint Louis University, lab experiments were combined with supercomputer modeling to identify molecules that boost antibiotics' effect on disease-causing bacteria.
National Institutes of Health
Public Release: 9-Nov-2016 Accelerating cancer research with deep learning
Using the Titan supercomputer at the Oak Ridge Leadership Computing Facility, a DOE Office of Science User Facility located at ORNL, Tourassi's team applied deep learning to extract useful information from cancer pathology reports, a foundational element of cancer surveillance. Working with modest datasets, the team obtained preliminary findings that demonstrate deep learning's potential for cancer surveillance.
Public Release: 3-Nov-2016
Science Mutational signatures mark cancer's smoking gun
A broad computational study of cancer genome sequences identifies telltale mutational signatures associated with smoking tobacco and demonstrates, for the first time, that smoking increases cancer risk by causing somatic mutations in tissues directly and indirectly exposed to tobacco smoke.
The Department of Energy's Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time.