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DOE NEWS RELEASES

Key: Meeting M      Journal J      Funder F

Showing releases 26-50 out of 50.

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Public Release: 10-Oct-2016
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Brain modulyzer provides interactive window into the brain
A new tool developed at Berkeley Lab allows researchers to interactively explore the hierarchical processes that happen in the brain when it is resting or performing tasks. Scientists also hope that the tool can shed some light on how neurological diseases like Alzheimer's spread throughout the brain.

Contact: Linda Vu
lvu@lbl.gov
510-495-2402
DOE/Lawrence Berkeley National Laboratory

Public Release: 5-Oct-2016
Nature Communications
For normal heart function, look beyond the genes
Berkeley Lab researchers have compiled a comprehensive genome-wide map of more than 80,000 enhancers considered relevant to human heart development and function. They went on to test two of the enhancers in mice, showing that when the enhancers were missing, the heart worked abnormally. The finding bolsters the importance of DNA segments once considered 'junk.'
National Institutes of Health

Contact: Sarah Yang
scyang@lbl.gov
510-486-4575
DOE/Lawrence Berkeley National Laboratory

Public Release: 3-Oct-2016
IEEE International Conference on Rebooting Computing
Turning to the brain to reboot computing
Computation is stuck in a rut. The integrated circuits that powered the past 50 years of technological revolution are reaching their physical limits. This predicament has computer scientists scrambling for new ideas. Researchers from Sandia National Laboratories will present three papers at the IEEE International Conference on Rebooting Computing held Oct. 17-19, highlighting the breadth of potential non-traditional neural computing applications.

Contact: Mollie Rappe
mrappe@sandia.gov
505-844-8220
DOE/Sandia National Laboratories

Public Release: 3-Oct-2016
Transformational X-ray project takes a step forward
A proposed upgrade to the Advanced Light Source -- which would provide new views of materials and chemistry at the nanoscale with X-ray beams up to 1,000 times brighter than possible now -- has cleared the first step in a Department of Energy approval process. The upgrade would enable new explorations of chemical reactions, battery performance, and biological processes.

Contact: Glenn Roberts Jr.
geroberts@lbl.gov
510-486-5582
DOE/Lawrence Berkeley National Laboratory

Public Release: 3-Oct-2016
Science Advances
Study yields new knowledge about materials for ultrasound and other applications
Scientists at the Department of Energy's Oak Ridge National Laboratory and their research partners have used neutron scattering to discover the key to piezoelectric excellence in the newer materials, which are called relaxor-based ferroelectrics. (A ferroelectric material has electrical polarization that is reversed by application of an electric field.) Their findings, published online in the journal Science Advances, may provide knowledge needed to accelerate the design of functional materials for diverse applications.
US Department of Energy Office of Science

Contact: Dawn Levy
levyd@ornl.gov
865-576-6448
DOE/Oak Ridge National Laboratory

Public Release: 31-Aug-2016
Nature Communications
Study finds potential new biomarker for cancer patient prognosis
Berkeley Lab researchers linked the overexpression of 14 genes related to cell division to cancer patients' prognosis and response to specific treatments. The findings could be used to develop a biomarker that doctors and patients use to make better informed decisions in clinical settings.
National Institutes of Health

Contact: Sarah Yang
scyang@lbl.gov
510-486-4575
DOE/Lawrence Berkeley National Laboratory

Public Release: 18-Aug-2016
Science
A new way to display the 3-D structure of molecules
Berkeley Lab and UC Berkeley Researchers have developed nanoscale display cases that enables new atomic-scale views of hard-to-study chemical and biological samples.

Contact: Glenn Roberts Jr.
geroberts@lbl.gov
510-486-5582
DOE/Lawrence Berkeley National Laboratory

Public Release: 17-Aug-2016
Nature Communications
Isotope research opens new possibilities for cancer treatment
A new study at Los Alamos National Laboratory and in collaboration with Stanford Synchrotron Radiation Lightsource greatly improves scientists' understanding of the element actinium. The insights could support innovation in creating new classes of anticancer drugs.

Contact: Nancy Ambrosiano
nwa@lanl.gov
505-667-0471
DOE/Los Alamos National Laboratory

Public Release: 17-Aug-2016
Nature
Unveiled: Earth's viral diversity
Plumbing the Earth's microbial diversity requires learning more about the poorly-studied relationships between microbes and the viruses that infect them, impacting their abilities to regulate global cycles. DOE JGI researchers utilized the largest collection of assembled metagenomic datasets to uncover over 125,000 partial and complete viral genomes. This single effort increases the number of known viral genes by a factor of 16, and provides researchers with a unique resource of viral sequence information.
US Department of Energy

Contact: David Gilbert
degilbert@lbl.gov
DOE/Joint Genome Institute

Public Release: 3-Aug-2016
Analytical Chemistry
Researchers at Sandia, Northeastern develop method to study critical HIV protein
Mike Kent, a researcher in Sandia National Laboratories' Biological and Engineering Sciences Center, is studying a protein called Nef involved in HIV progression to AIDS with the ultimate goal of blocking it. He and his collaborators have developed a new hybrid method to study this HIV protein that compromises the immune system. The method also could work on many other proteins that damage cellular processes and cause diseases.
National Institutes of Health

Contact: Mollie Rappe
mrappe@sandia.gov
505-844-8220
DOE/Sandia National Laboratories

Public Release: 29-Jul-2016
Science Advances
Researchers find molecular switch that triggers bacterial pathogenicity
A new study led by scientists at Berkeley Lab has revealed that the supercoiling of bacterial chromosomes around histone-like proteins can trigger the expression of genes that make the microbe invasive. The discovery could provide a new target for the development of drugs to prevent or treat bacterial infection.
National Institutes of Health, US Department of Energy

Contact: Sarah Yang
scyang@lbl.gov
510-486-4575
DOE/Lawrence Berkeley National Laboratory

Public Release: 27-Jul-2016
Environmental Science & Technology
All e-cigarettes emit harmful chemicals, but some emit more than others
While previous studies have found that electronic cigarettes emit toxic compounds, a new study from Lawrence Berkeley National Laboratory has pinpointed the source of these emissions and shown how factors such as the temperature, type, and age of the device play a role in emission levels, information that could be valuable to both manufacturers and regulators seeking to minimize the health impacts of these increasingly popular devices.

Contact: Julie Chao
jhchao@lbl.gov
510-486-6491
DOE/Lawrence Berkeley National Laboratory

Public Release: 19-Jul-2016
Nature Communications
Scientists create new thin material that mimics cell membranes
Materials scientists have created a new material that performs like a cell membrane found in nature. Such a material has long been sought for applications as varied as water purification and drug delivery. The material can assemble itself into a sheet thinner but stabler than a soap bubble, the researchers report July 12 in Nature Communications.
Department of Energy

Contact: Mary Beckman
mary.beckman@pnnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory

Public Release: 18-Jul-2016
Nature Chemical Biology
Scientists determine structure of enzyme linked with key cell-signaling protein
Scientists have captured atomic level snapshots showing how one key enzyme modifies a protein involved in turning genes on or off inside cells. Understanding this process helps explain how complex organisms can arise from a finite number of genes. The research also identifies links between defects in this particular enzyme and certain cancers, potentially pointing to new drug targets.
National Institutes of Health, Stony Brook University-Brookhaven National Laboratory Seed Grant, DOE/Office of Science, and Eli Lilly Company

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory

Public Release: 29-Jun-2016
Cell
Ovarian cancer study provides painstaking look at inner workings of tumors
Scientists have examined the collections of proteins in the tumors of 169 ovarian cancer patients to identify critical proteins present in their tumors. The researchers say their achievement illustrates the power of combining genomic and proteomic data -- an approach known as proteogenomics -- to yield a more complete picture of the biology of a cancer that is the fifth leading cause of cancer deaths among women in the United States.
NIH/National Cancer Institute, National Institutes of Health

Contact: Tom Rickey
tom.rickey@pnnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory

Public Release: 16-Jun-2016
2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging
Innovative device allows 3-D imaging of the breast with less radiation
Adding a new device to an existing breast molecular imaging system allows the system to get six times better contrast of cancer lesions in the breast, providing the same or better image quality while also potentially reducing the radiation dose to the patient by half. The device may also allow for 3-D molecular breast images at higher resolution than current 2-D scans in a format that may be used alongside 3-D digital mammography.
Commonwealth of Virginia's Center for Innovative Technology, Dilon Technologies

Contact: Kandice Carter
kcarter@jlab.org
757-269-7263
DOE/Thomas Jefferson National Accelerator Facility

Public Release: 16-Jun-2016
Journal of Virology
Sandia researchers discover mechanism for Rift Valley fever virus infection
Viruses can't live without us -- literally. As obligate parasites, viruses need a host cell to survive. Scientists are exploiting this characteristic by developing therapeutics that close off pathways necessary for viral infection, essentially stopping pathogens in their tracks. Rift Valley fever virus and other bunyaviruses may soon be added to the list of viruses denied access to a human host. Sandia National Laboratories researchers have discovered a mechanism by which RVFV hijacks the host machinery to cause infection.

Contact: Patti Koning
pkoning@sandia.gov
925-294-4911
DOE/Sandia National Laboratories

Public Release: 7-Jun-2016
Journal of Medical Devices
Chemical 'sponges' designed to soak up toxic cancer-fighting drugs after targeting tumors
Researchers are creating materials for a cancer treatment system that can limit the side effects of chemotherapy drugs by quickly removing them from the body after use.

Contact: Glenn Roberts Jr.
geroberts@lbl.gov
510-486-5582
DOE/Lawrence Berkeley National Laboratory

Public Release: 6-Jun-2016
Nature Chemical Biology
Copper is key in burning fat
A new study led by a Berkeley Lab scientist and UC Berkeley professor establishes for the first time copper's role in fat metabolism, further burnishing the metal's reputation as an essential nutrient for human physiology.
National Institutes of Health

Contact: Sarah Yang
scyang@lbl.gov
510-486-4575
DOE/Lawrence Berkeley National Laboratory

Public Release: 1-Jun-2016
Bone
Team identifies gene involved with fracture healing
New identification of a gene involved in the fracture healing process could lead to the development of new therapeutic treatments for difficult-to-heal injuries.

Contact: Anne Stark
stark8@llnl.gov
925-422-9799
DOE/Lawrence Livermore National Laboratory

Public Release: 31-May-2016
Proceedings of the National Academy of Sciences
RNA simulations boost understanding of retroviral diseases
New molecular dynamics research into how RNA folds into hairpin-shaped structures called tetraloops could provide important insights into new treatments for retroviral diseases.

Contact: Nancy Ambrosiano
nwa@lanl.gov
505-667-0471
DOE/Los Alamos National Laboratory

Public Release: 27-May-2016
Nature Microbiology
PNNL helps lead national microbiome initiative
Scientists Janet Jansson and Ljiljana Paša-Toli are part of a core group of scientists leading a national effort to understand communities of microorganisms and their role in climate science, food production and human health.

Contact: Tom Rickey
tom.rickey@pnnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory

Public Release: 25-May-2016
Radiation 101: DoseNet delivers environmental data as an educational tool
A network of radiation-monitoring devices and a companion website and open-source code serve as educational and outreach tools for an international project called DoseNet that stretches from Northern California classrooms to a city hall in Japan. Its broad aim is to inform and connect students and communities using science and data as common ground.

Contact: Glenn Roberts Jr.
geroberts@lbl.gov
510-486-5582
DOE/Lawrence Berkeley National Laboratory

Public Release: 20-May-2016
Angewandte Chemie
Neutrons probe structure of enzyme critical to development of next-generation HIV drugs
A team led by the Department of Energy's Oak Ridge National Laboratory used neutron analysis to better understand a protein implicated in the replication of HIV, the retrovirus that causes AIDS. The enzyme, known as HIV-1 protease, is a key drug target for HIV and AIDS therapies. The multi-institutional team used neutron crystallography to uncover detailed interactions of hydrogen bonds at the enzyme's active site, revealing a pH-induced proton 'hopping' mechanism that guides its activity.
DOE/Office of Science

Contact: Jeremy Rumsey
rumseyjp@ornl.gov
865-576-2038
DOE/Oak Ridge National Laboratory

Public Release: 19-May-2016
Journal of Orthopaedic Research
New research could personalize medicine for arthritis patients
Recently, a team of scientists from Lawrence Livermore National Laboratory, University of California, Davis, University of California, Merced and Regeneron Pharmaceuticals examined the whole-joint gene expression by RNA sequencing at one day, one, six and 12 weeks after injury. The team used a new, non-invasive tibial compression mouse model of PTOA, that mimics ACL rupture in humans from a single high-impact injury.

Contact: Anne Stark
stark8@llnl.gov
925-422-9799
DOE/Lawrence Livermore National Laboratory

Showing releases 26-50 out of 50.

<< < 1 | 2

 

 

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