Beta-HPV can directly cause skin cancer in immunocompromised people
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Jul-2025 18:11 ET (30-Jul-2025 22:11 GMT/UTC)
Researchers at the National Institutes of Health (NIH) have shown for the first time that a type of human papillomavirus (HPV) commonly found on the skin can directly cause a form of skin cancer called cutaneous squamous cell carcinoma (cSCC) when certain immune cells malfunction. cSCC is one of the most common cancers in the United States and worldwide. Previously, scientists believed HPV merely facilitated the accumulation of DNA mutations caused by ultraviolet (UV) radiation, usually the primary driver of cSCC. The findings were published today in The New England Journal of Medicine.
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