Conservation of opposing CD4 and LAG-3 functions from sharks to humans. (IMAGE)

Fujita Health University

Conservation of opposing CD4 and LAG-3 functions from sharks to humans.

Caption

Conservation of their respective cytoplasmic tail motifs, CxC/H in the case of CD4 and an ITIM-like motif in the case of LAG-3, supports that competition between CD4 and LAG-3 for binding of kinase LCK is a conserved core part of the jawed vertebrate immune system.

Credit

The figure was created by Johannes M. Dijkstra. The photograph of the cloudy catshark was provided by Aqua World Ibaraki Prefectural Oarai Aquarium.

Usage Restrictions

Credit must be given to the creator.

License

CC BY

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