Schematic of novel stem cell therapy with metabolic glycoengineering (MGE) for brain repair after cardiac arrest (CA). (IMAGE)

University of Maryland School of Medicine

Schematic of novel stem cell therapy with metabolic glycoengineering (MGE) for brain repair after cardiac arrest (CA).

Caption

Figure 1. Schematic of novel stem cell therapy with metabolic glycoengineering (MGE) for brain repair after cardiac arrest (CA). Conditions were characterized and optimized in vitro to modify human neural stem cells by using the TProp sugar analog (Ac5ManNTProp). The efficacy of the transplanted metabolically glycoengineered neural stem cells (MGE-NSC) for brain repair and how TProp analog affected the fate of neural stem cells were evaluated within a cardiac-arrest-induced brain injury rat model. Results indicated that MGE improved the viability and differentiation of neural stem cells, inhibited neuroinflammation, and provided neuroprotection after in vivo transplantation.

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