Example of histiocytic sarcoma secondary to T-lymphoblastic leukemia with MYC proto-oncogene (MYC) gene rearrangement (IMAGE)

Xia & He Publishing Inc.

Example of histiocytic sarcoma secondary to T-lymphoblastic leukemia with MYC proto-oncogene (MYC) gene rearrangement

Caption

A 2 year-old boy with mediastinal mass, hepatosplenomegaly, and circulating blasts was diagnosed with T-lymphoblastic leukemia with MYC-gene rearrangement by fluorescence in situ hybridization (FISH) and aberrant cytogenetics displaying 46,XY,t(8;14)(q24;q11.2) and der(12)t(12;20)(q11;q13.3), der(20)t(12;20)(q21;q13.3)[9]/46,XY[5]. The patient was partially responsive to chemotherapy before receiving a matched unrelated donor cord blood transplant. (a-b) On day 110 after transplant, bone marrow biopsy revealed diffuse infiltration of atypical histiocytes and occasional Touton giant cells, as shown here under hematoxylin and eosin staining at (a) 40× magnification and (b) 400× magnification. (c) FISH confirmed the persistence of MYC gene rearrangement. Positron emission tomography-computed tomography scan revealed disseminated disease. The patient died despite chemotherapy following the Langerhans cell histiocytosis III protocol. FISH, fluorescence in situ hybridization.

Credit

Jinjun Cheng, Guo Zhu

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