Imaging olfactory epithelium of non-human primates. (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Imaging olfactory epithelium of non-human primates.

Caption

Imaging olfactory epithelium of NHPs. (A) Images were taken using Quest system (approved for clinical use) of olfactory bulb, muscle, olfactory epithelium, and brain of 4 NHPs, after intravenous injection of Tsp1a-IR800P. (B) Quantification of near-fluorescence intensity demonstrates that signal from olfactory epithelium is significantly higher than that from surrounding tissues. (C) Fluorescent confocal microscopy images of olfactory bulb, muscle, olfactory epithelium, and brain tissues of same NHPs. (D) Schematic depiction of potential use of Tsp1a-IR800P in physician’s office setting using Quest or other vendor NIR fluorescence imaging systems. ****P ≤ 0.0001. a.u. = arbitrary units; olf. bulb = olfactory bulb; olf. epi = olfactory epithelium.

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Image created by Adilbay and coworkers in the Department of Radiology MSK.

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