Image (IMAGE)

Higher Education Press

Image

Caption

In summary, macrophages secrete IFN-β, activating the IFN-β-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-β-secreting macrophages. These recruited macrophages further enhance STAT1 phosphorylation, establishing a self-reinforcing positive feedback loop between MICFs and macrophages. Knockdown of IFNAR disrupts this loop, facilitating efficient reprogramming.

Credit

Hao Wang, Junbo Yang, Yihong Cai, Yang Zhao

Usage Restrictions

none

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.