Schematic diagram of two groups of antibodies recognizing different epitopes of Zika NS1 and their differential protective mechanisms (IMAGE)

Tsinghua University Press

Schematic diagram of two groups of antibodies recognizing different epitopes of Zika NS1 and their differential protective mechanisms

Caption

Group I antibodies (3G2 and 4B8) recognize the previously unreported epitopes on the outer surface of the Zika virus (ZIKV) NS1 dimer. Group II antibodies (4F10, 2E11, and 14G5) recognize the common epitopes at the distal end of the ZIKV NS1 β-ladder domain. Group I antibodies have stronger recognition of the cell surface form of NS1, and their IgG and Fab completely inhibit the endothelial permeability caused by ZIKV sNS1 proteins. The blockade efficiency of Group II antibodies is related to their affinity for the ZIKV sNS1 protein and the presence of full length IgG.

Credit

Hongli Hu, the Chinese University of Hong Kong

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