Development and Application of DFSP Skin Tumor Organoids (IMAGE)
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This schematic illustrates the process of developing patient-derived skin tumor organoids from Dermatofibrosarcoma Protuberans (DFSP). The workflow includes organoid culture, characterization through HE staining, whole exome sequencing, and single-cell RNA sequencing (scRNA-seq) to analyze cell types. Drug sensitivity analysis highlights the effects of imatinib and metformin, revealing metformin’s unique role in modulating immune pathways, which supports its potential as a therapeutic agent for DFSP.
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Xinxin Han, Shanghai Lisheng Biotech
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