Mechanisms of metastasis: Extracellular vesicles bind to the recipient cell membrane (IMAGE)
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Extracellular vesicles are tiny spheres that cells release to send molecules or messages to other cells, often as a means of seeding cancer elsewhere in the body. In a new study, researchers found that the vesicles adhere to the recipient cells primarily through interactions of two receptors — integrins and GM1 — on the vesicle and laminins, which are proteins with attached carbohydrate molecules on the cell membrane.
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Institute for Glyco-core Research
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