Alcohol dehydrogenase 4-mediated retinol metabolism inhibits hepatocellular carcinoma progression through inhibiting the Wnt/β-catenin pathway (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Alcohol dehydrogenase 4-mediated retinol metabolism inhibits hepatocellular carcinoma progression through inhibiting the Wnt/β-catenin pathway

Caption

The downregulation of ADH4 expression induces hepatocyte apoptosis, thereby contributing to liver fibrosis and the initiation of hepatocellular carcinoma (HCC). Moreover, sustained suppression of ADH4 in HCC cells disrupts retinoic acid synthesis, leading to reduced expression of the Wnt/β-catenin signaling inhibitor WIF-1 via RARs/RXRs-mediated mechanisms. This disruption fosters the upregulation of oncogenic regulators such as c-Myc and Cyclin D1, thereby accelerating HCC progression. Notably, the combination therapy involving all-trans retinoic acid (ATRA) and cisplatin exhibits a pronounced synergistic antitumor effect.

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Dr. Nan Wang

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