Experimental design and protective effects of STN-DBS across different groups. (IMAGE)
Caption
(A) Experimental design. (B) Behavior assessments using open field tests. Heatmaps illustrate time spent (red) and movement trajectories (green). The PD group exhibited decreased movement speed compared to the Sham group; however, both the NST and ST groups showed increased movement speed relative to the PD group. (C) EEG signals from the right M1. The PD group exhibited a typical β band, while EEG patterns in the NST and ST groups were similar to those in the Sham group. (D) Phase-amplitude coupling (PAC) analysis in the right M1. The PD group exhibited beta/ripple coupling, absent in the NST and ST groups. (E) TH staining in the right SN. TH-positive cell counts in the PD group were lower than the Sham group. The NST group showed levels comparable to the PD group, while the ST group had more TH-positive cells than both the PD and NST groups. The square represents the target area in the right SN where 6-OHDA was injected. (F to I) Boxplots show (F) the speed in the open-field test, (G) EEG power, (H) PAC, and (I) TH-positive cell counts. Circles represent individual values, and error bars show SD. Statistical analysis was conducted using one-way ANOVA followed by FDR correction. *P < 0.05, **P < 0.01, ****P < 0.0001, and ns indicating no significant difference.
Credit
Dan Du, Peking University Third Hospital
Usage Restrictions
News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
License
Licensed content