Overview of the design and methods used in this study. (IMAGE)

First Hospital of Jilin University

Overview of the design and methods used in this study.

Caption

 (A) A systematic review summarising modifiable factors and coexisting disorders. (B) Linkage disequilibrium score regression (LDSC) analysis exploring the genetic correlations of factors with irritable bowel syndrome (IBS). (C) Mendelian randomisation (MR) and multiresponse MR (MR2) explore the causal associations of modifiable factors and coexisting disorders with IBS. Solid arrows denote causal effects; dashed arrows and crosses denote causal effects prohibited by MR assumptions II and III. CAUSE, Causal Analysis Using Summary Effect estimates; GWAS, genome-wide association study; IVW, inverse-variance weighted.

Credit

By Di Liu, Meiling Cao, Shanshan Wu, et al.

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License

CC BY-NC

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