Key differences in protein structure that result in antifungal resistance (IMAGE)

Chiba University

Key differences in protein structure that result in antifungal resistance

Caption

Models of the proteins produced by Madurella fahalii: CYP51A (A and C) and CYP51A2 (B and D). In each panel, itraconazole and heme are illustrated in a stick representation in the upper and lower parts, respectively. (A) and (B) represent the overall structure of CYP51 proteins. In (C) and (D), the active centers of (A) and (B) were enlarged with their protein backbones made translucent, respectively.

Credit

Associate Professor Takashi Yaguchi from Chiba University, Japan

Usage Restrictions

Credit must be given to the creator.

License

CC BY

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