The chemopreventive effects of native Brazilian plants on stomach cancer: A review of the last 25 years (IMAGE)
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Figure 3: Effects of compounds isolated from Physalis on HGC-27 and SGC-7901 stomach cancer cell lines.
According to Fang et al. (2022), Physalin B suppressed the expression of cell cycle regulatory proteins, including cyclin D1, cyclin D3, CDK4, CDK6 and cyclin E, as well as increasing the protein levels of caspase-8, caspase-3, caspase-7 and PARP, promoting apoptosis. According to Dai et al. (2020), Physapubescin B inhibited cell proliferation and induced apoptosis in gastric cancer cells by suppressing the phosphorylation of STAT3 and the expression of downstream targets such as STAT3, STAT3 Tyr705, p-STAT3, XIAP, c-Myc, cyclin D1 and IL-11. Meanings: ↑: increased, and ↓: decreased. Abbreviations: CDK4: Cyclin-dependent kinase 4; CDK6: Cyclin-dependent kinase 6; c-Myc: Cellular Myc; IL11: interleukin-11; PARP: poly(ADP-ribose) polymerase); p-STAT3: Phospho-Stat3; STAT3: signal transducer and activator of transcription; XIAP: X-linked inhibitor of apoptosis protein. Own authorship using open-access illustrations under CC BY 4.0 license from smart.servier.com and canva pro.
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