Figure 1. Excitation-Inhibition Balance Regulated by Mini-Exon B of PTPδ (IMAGE)

Institute for Basic Science

Figure 1. Excitation-Inhibition Balance Regulated by Mini-Exon B of PTPδ

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Deletion of mini-exon B in the synaptic adhesion molecule PTPδ leads to altered neural connectivity from the entorhinal cortex to the dentate gyrus (left panel). In mice lacking mini-exon B, excitatory input onto granule cells is reduced, while excitatory input onto inhibitory interneurons is increased (top right panel). At the molecular level, this is likely due to a reduced trans-synaptic interaction between PTPδ and IL1RAP at excitatory synapses on granule cell dendrites (bottom right panel).

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Institute for Basic Science

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