Network pharmacology suggests the potential mechanism of Ejiao in regulating chronic obstructive pulmonary disease (IMAGE)
Caption
(a, b) Construction and analysis of drug-disease targets; (c, d) GO and KEGG enrichment maps. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.
Ejiao can significantly improve the lung function indicators of COPD model mice, reduce the content of inflammatory factors in bronchoalveolar lavage fluid, increase the estrogen content in serum, and reduce the number of peritoneal macrophages. HE pathological observation and Western blot analysis showed that Ejiao can improve lung injury, and its mechanism of action may involve regulating estrogen levels in the body and affecting the ER/AKT/NF-κB signaling pathway, thereby alleviating inflammatory response and improving lung injury.
Credit
Hongtao Jin, Bin Wang, Siman Sun, Tianyu Zhou, Xiaoyu Fan
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CC BY-NC