Adenosine Phosphate Signaling Subtypes in Melanoma TME (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Adenosine Phosphate Signaling Subtypes in Melanoma TME

Caption

Five signaling subtypes identified by NMF clustering. Subtype 5 (high APsig) correlates with immune-rich "hot" tumors, while Subtype 2 (low APsig) exhibits metabolic reprogramming and hypoxia. High APsig is associated with activated myeloid cells (e.g., M1 macrophages, cDC1) and T cell infiltration.

Credit

The corresponding authors Dr. Xiang Chen, Dr. Jiachen Liu, and Dr. Yantao Xu.

Usage Restrictions

Marked by the credited.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.