Schematic representation of nano prodrug micelles for enhanced ferroptosis and chemotherapy. (IMAGE)

Tsinghua University Press

Schematic representation of nano prodrug micelles for enhanced ferroptosis and chemotherapy.

Caption

The amphiphilic polymer of coupled Fc and disulfide modified HNK (PFSH) was self-assembled into micelles loaded with the chemotherapeutic drug (HCPT). The micelles disintegrated in the high GSH tumor microenvironment, releasing iron catalyst (Fc), anticancer drugs (HCPT, HNK), and GPX4 inhibitor (HNK) to achieve the combination of ferroptosis and chemotherapy and overcoming chemotherapeutic drug resistance through a dual-mechanism that significantly improved efficacy.

Credit

Nano Research, Tsinghua University Press

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.