Post-Antibiotic Treatment May Help Keep Newborn Immune System Development on Track (IMAGE)

Cincinnati Children's Hospital Medical Center

Post-Antibiotic Treatment May Help Keep Newborn Immune System Development on Track

Caption

This illustration outlines the key role that gut-produced inosine plays in supporting immune cell development in the lung. When antibiotics disrupt the gut microbiota (dysbiosis), the amount of CD8+ memory T cells declines, resulting in increased risk of poor outcomes when lung infections occur in infancy and later in life. In mice, inosine supplements improved lung immune function. 

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Cincinnati Children's

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