Cigarette smoke and decreased DNA repair by Xeroderma Pigmentosum Group C use a double hit mechanism for epithelial cell lung carcinogenesis (IMAGE)
Caption
Figure 7: XPC gene expression is decreased in human non-small cell lung cancers compared to normal subject-matched lung. (A) XPC mRNA expression decreased in unmatched samples from lung adenocarcinoma (AdenoCA) compared to benign lung from the TCGA database. (B) Decreased XPC mRNA expression in frozen lung adenocarcinoma compared to non-cancerous (benign) lung. Box plot with median and 25–75%, whiskers at 10% and 95%. (C) Ratio of XPC mRNA expression in lung adenocarcinoma to subject matched benign lung resected at the time of surgery, individual subjects shown on Y-axis. (D) XPC mRNA expression decreased in unmatched samples from the TCGA database of lung squamous cell carcinoma (LUSC) and benign lung. (E) Decreased median XPC mRNA expression in frozen lung squamous cell carcinoma compared to benign lung. Box plot with median and 25–75%, whiskers at 10% and 95%. (F) Ratio of XPC mRNA expression in lung squamous cell carcinoma to subject-matched benign lung resected at the time of surgery, individual subjects shown on Y-axis. ***p < 0.001 by one way ANOVA.
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