Fig. 1 (IMAGE)
Caption
Patients with scleroderma renal crisis demonstrated specific enrichment of CD14+ monocytes with increased EGR1 expression and activation of NF-κB–related pathways. Trajectory analysis indicated that they differentiated into macrophages and expressed high levels of THBS1 in the kidney. In patients with SSc-ILD, CD8+ effector memory T cells with increased type II ISG expression were enriched in peripheral blood. A similar cell population was also enriched in the lung tissue of patients with advanced SSc-ILD, suggesting migration of CD8+ T cells from peripheral blood to the lung.
SSc, systemic sclerosis; ILD, interstitial lung disease; WBC, white blood cells; ISG, interferon signature genes.
Credit
Hiroshi Shimagami and Masayuki Nishide
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