Overview of the MIf-PET system and example results from a visual oddball task in healthy and Alzheimer's disease participants. (IMAGE)
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Figure 1. Overview of the MIf-PET system and example results from a visual oddball task in healthy and Alzheimer's disease participants. (a) Prototype of the high-resolution, upright PET scanner under development. (b) Schematic illustration of the MIf-PET system integrating a motion-tracked upright PET gantry, augmented reality (AR) headset, and subject positioning for immersive functional imaging. (c) Task timing and predicted neural activation profile over a block design paradigm during functional PET acquisition. (d) Visual oddball task design, with randomized presentation of standard, novel, and target faces. (e) Example raw pupillometry data showing pupil diameter fluctuations aligned to blink events across an extended oddball paradigm. (f) Example of pupil dilation responses to different stimulus types in healthy controls and Alzheimer's disease (AD) participants. Healthy individuals exhibit strong phasic responses to novel and target stimuli, while AD participants show diminished pupil reactivity.
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Image created by Z. Wang et al., Weill Cornell Medicine, New York, NY.
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