Exploring the impact of RUNX2 deficiency in skull development of mice (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Exploring the impact of RUNX2 deficiency in skull development of mice

Caption

These 3D renderings of mouse skulls clearly show the effects of RUNX2 deficiency. Fgfr3-creER mice, which were the control group, and Fgfr3-Runx2cHet mice, which had a working copy of the Runx2 gene, exhibited normal cranial development. In contrast, Fgfr3-Runx2cKO mice, in which the Runx2 gene was completely suppressed, exhibited several craniofacial deformities, including premature ossification of the synchondroses.

Credit

Dr. Shawn A. Hallett and Renny T. Franceschi from University of Michigan School of Dentistry Image Source Link: https://www.nature.com/articles/s41413-025-00426-z

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