The role of (non-)modifiable factors on tau-spatial-extent and level-rise. (IMAGE)
Caption
Figure 1. The role of (non-)modifiable factors on tau-spatial-extent and level-rise. Factors that were tested in this study are illustrated on the left. Tau-spatial-extent (light blue) relates to the volumetric extent of newly affected regions and can be captured as flow rate (volume/month) across time. Tau-level-rise (blue) reflects the increase in tau burden in regions that had already been affected by tau pathology at baseline. The brain surfaces depict an example of a male MCI patient, who was 67-years old, had 12 years of education, a BMI of 28.5 and intermediate hypertension at baseline and who became a dementia patient at follow-up. Areas in blue relate to more affected regions and areas in light blue to newly affected regions four years after baseline. The volumetric extent of the light blue areas was used to quantify tau-spatial-extent, whereas tau-level-rise was quantified as the change in tau burden in the blue areas. Below the brain surfaces, we have depicted the effect (unstandardized estimates) for the significant fixed and interaction effects relating to tau-spatial-extent (right) or tau-level-rise (left).
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Image created by Hoenig et al., Research Center Juelich, Juelich, PhD, created with biorender.com.
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