Representative coronal (left) and transverse (right) CT and 11C-PABA PET/CT images from a 33-year-old female with cystic fibrosis and confirmed M. abscessus infection in a 45-minute dynamic PET scan after an intravenous injection of 518 MBq of 11C-PABA. (IMAGE)
Caption
Figure 1. Representative coronal (left) and transverse (right) CT and 11C-PABA PET/CT images from a 33-year-old female with cystic fibrosis and confirmed M. abscessus infection in a 45-minute dynamic PET scan after an intravenous injection of 518 MBq of 11C-PABA. In the first nine minutes of the scan 11C-PABA got distributed systemically, followed by rapid clearance via heptic and renal excretion, showing accumulation of 11C-PABA only inside the affected lesion in the last 10 minutes. Not all lesions visualized on CT were PET avid, suggesting that some lesions may be sterile or had very low bacterial burden. The y axis shows time in minutes.
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Masias-Leon et al., Johns Hopkins University, School of Medicine, Baltimore, MD. Reprinted with permission of the American Thoracic Society. Copyright © 2025 American Thoracic Society. All rights reserved. Cite: Masias-Leon, et-al. 2025. Dynamic 11C-PABA PET/CT for Visualizing Pulmonary Mycobacteroides abscessus Infections. American Journal of Respiratory and Critical Care Medicine. In-Press Article. Page 40. The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society.
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