Growing blood vessels in liver organoids (VIDEO)
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This 3D animation shows an advanced liver organoid capable of forming its own internal blood vessels. Using a multilayered gel process, researchers coaxed vessel-forming sinusoidal cells (bright green) to migrate and sprout towards a more oxygenated upper layer. In the red areas, the sinusoidal cells interacted with neighboring liver cells to complete the formation of functional blood vessels. Other liver cells were stained blue (DAPI) to allow the blood vessel forming cells to be counted. Detailed findings were published June 25, 2025 in Nature Biomedical Engineering.
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Cincinnati Children's
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