Analysis of Indian genomes (IMAGE)
Caption
The new analysis traces Indian ancestry back to a migration out of Africa around 50,000 years ago, after which humans interbred with Neanderthals and Denisovans and then spread throughout Eurasia. Some genes acquired from those now-extinct ancestors affect immune response. About 10,000 years ago, there was an influx of farmers from Iran and nomadic herders from the Central Asian steppe to India, who mixed with the local hunter-gatherer. Then, 5,000 years ago, endogamy led to bottlenecks in many Indian communities. Together, this complex evolutionary history has shaped the genetic variation and health and disease in India.
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Priya Moorjani and Elise Kerdoncuff, UC Berkeley
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