Subhrangsu S. Mandal, center, is the lead author of a new study that could lead to new treatments for heart disease (IMAGE)
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Scientists at The University of Texas at Arlington have identified a new enzyme that can be “turned off” to help the body maintain healthy cholesterol levels—a significant development that could lead to new treatments for diseases that affect millions of Americans.
“We found that by blocking the enzyme IDO1, we are able to control the inflammation in immune cells called macrophages,” said Subhrangsu S. Mandal, lead author of a new peer-reviewed study and professor of chemistry at UT Arlington. “Inflammation is linked to so many conditions—everything from heart disease to cancer to diabetes to dementia. By better understanding IDO1 and how to block it, we have the potential to better control inflammation and restore proper cholesterol processing, stopping many of these diseases in their tracks.”
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