Patient-specific EAC treated on-a-chip (IMAGE)

Wyss Institute for Biologically Inspired Engineering at Harvard

Patient-specific EAC treated on-a-chip

Caption

These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy. On the left, the researchers used immunofluorescence stainings to visualize markers of esophageal adenocarcinoma cells in the upper EAC channel and a stromal marker in the lower stromal channel, indicating chemosensitivity in the cancer chip on the left and chemoresistance in the cancer chip on the right (bottom row). On the right, they looked at the same Cancer Chips using scanning electron microscopy, with the cell and tissue morphologies showing chemotherapy sensitivity and resistance. 

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Wyss Institute at Harvard University

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