Single-cell transcriptomic profiles of PBMCs from JIA patients and HCs. (IMAGE)
Caption
(A, B) Identified cell populations. Eleven clusters were found after UMAP clustering of JIA and HC cells. The dots indicate single cells with colors representing the cell type. (C) Violin plots of expression of cell markers. (D) Relative proportions of cell subtypes in JIA and HC PBMCs. (E) Percentage of each cellular population in HC and JIA. (F) Enrichment analysis of HC and JIA for DEGs in monocyte. (G–J) The box plots of the levels of two gene ontology biological process terms in eleven clusters from HC, JIA, non-sJIA, and sJIA samples. PBMCs, peripheral blood mononuclear cells; JIA, juvenile idiopathic arthritis; sJIA, systemic juvenile idiopathic arthritis; HC, healthy control; DEGs, differentially expressed genes.
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Genes & Diseases
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