Link Between Premature Aging of Knee Joints and Acquired Immune Deficiency Syndrome (AIDS) Treatment (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Link Between Premature Aging of Knee Joints and Acquired Immune Deficiency Syndrome (AIDS) Treatment

Caption

Lopinavir-induced Zmpste24 inhibition compromised nuclear membrane stability, reducing the interaction between the nuclear membrane-binding protein Usp7 and Mdm2. This disruption activated the Usp7/Mdm2/p53 pathway, accelerating cellular senescence and OA development. 

Credit

Dr. Zanjing Zhai from Shanghai Jiaotong University, Shanghai Image Source Link: https://www.nature.com/articles/s41413-025-00431-2#author-information

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