To disentangle the two models, St. Jude researchers methodically tweaked the ability of the transcription factor Gcn4 to phase separate. (IMAGE)

St. Jude Children's Research Hospital

To disentangle the two models, St. Jude researchers methodically tweaked the ability of the transcription factor Gcn4 to phase separate.

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Published today in Molecular Cell, co-corresponding authors Tanja Mittag, PhD, St. Jude Department of Structural Biology, and Aseem Ansari, PhD, St. Jude Department of Chemical Biology & Therapeutics, reconciled two competing models of transcriptional activity, demonstrating nuance to the role of phase separation in transcription.

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Courtesy of St. Jude Children's Research Hospital

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