Nutrients and lipids shape bone marrow blood stem cells from health to aging and leukemia (IMAGE)

Max Planck Institute of Immunobiology and Epigenetics

Nutrients and lipids shape bone marrow blood stem cells from health to aging and leukemia

Caption

Comprehensive analysis of blood stem cells: Using advanced FACS sorting and innovative low-input methods, blood stem cells (HSPCs) and their progenitors were isolated from human bone marrow and examined under different age and disease conditions. By integrating transcriptomic, metabolomic, and lipidomic data, molecular changes during differentiation, aging, and leukemia could be characterized, revealing new approaches to maintain stem cell health.

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© MPI of Immunobiology & Epigenetics, Cabezas-Wallscheid

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